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公开(公告)号：US07780628B1
公开(公告)日：2010-08-24
申请号：US09562493
申请日：2000-05-01
申请人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J. Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
发明人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J. Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
IPC分类号： A61M29/00
CPC分类号： A61M25/00 , A61B17/12013 , A61B2017/00243 , A61B2017/061 , A61B2017/22054 , A61F2002/068 , A61M1/101 , A61M1/1018 , A61M1/1034 , A61M1/106 , A61M1/107 , A61M1/1072 , A61M1/1096 , A61M1/122 , A61M1/125 , A61M1/3653 , A61M1/3659 , A61M25/0075 , A61M25/10 , A61M25/1011 , A61M2025/1052 , A61M2210/1082 , A61M2210/125
摘要： Methods and apparatus are provided for treating congestive heart by actively or passively enhancing perfusion to the renal arteries. A first embodiment comprises a specially configured balloon catheter and extracorporeal pump, wherein the pump operates in a “once-through” fashion or alternating volume displacement mode. In another embodiment the catheter includes a pair of balloons to isolate a region of the aorta, and a third balloon that directs flow into the renal arteries. In still further embodiments, a stent or cuff having a constricted region is deployed in or around the aorta, respectively, to create a backpressure upstream of the stent or cuff. Methods of enhancing renal perfusion also are provided.
摘要翻译： 提供了通过积极或被动地增强对肾动脉灌注的治疗充血性心脏的方法和装置。 第一实施例包括特别配置的气囊导管和体外泵，其中泵以“一次通过”方式或交替容积位移模式操作。 在另一个实施例中，导管包括一对隔离主动脉区域的气球和将流动引导到肾动脉的第三气囊。 在另外的实施例中，具有收缩区域的支架或袖带分别展开在主动脉或其周围，以在支架或袖带的上游产生背压。 还提供了增强肾脏灌注的方法。
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公开(公告)号：US07335192B2
公开(公告)日：2008-02-26
申请号：US10438176
申请日：2003-05-13
申请人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
发明人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
CPC分类号： A61B17/1219 , A61B17/12013 , A61B17/12036 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B2017/00243 , A61B2017/00898 , A61B2017/061 , A61B2017/22054 , A61F2002/068 , A61M1/1006 , A61M1/1008 , A61M1/101 , A61M1/1018 , A61M1/1034 , A61M1/1072 , A61M1/122 , A61M1/125 , A61M1/3653 , A61M1/3659 , A61M25/00 , A61M25/0075 , A61M25/10 , A61M25/1011 , A61M27/002 , A61M2025/1052 , A61M2210/1082 , A61M2210/125
摘要： Methods and apparatus are provided for treating congestive heart by actively or passively enhancing perfusion to the renal arteries. A first embodiment comprises a specially configured balloon catheter and extracorporeal pump, wherein the pump operates in a “once-through” fashion or alternating volume displacement mode. In another embodiment the catheter includes a pair of balloons to isolate a region of the aorta, and a third balloon that directs flow into the renal arteries. In still further embodiments, a stent or cuff having a constricted region is deployed in or around the aorta, respectively, to create a backpressure upstream of the stent or cuff. Methods of enhancing renal perfusion also are provided.
摘要翻译： 提供了通过积极或被动地增强对肾动脉灌注的治疗充血性心脏的方法和装置。 第一实施例包括特别配置的气囊导管和体外泵，其中泵以“一次通过”方式或交替容积位移模式操作。 在另一个实施例中，导管包括一对隔离主动脉区域的气球和将流动引导到肾动脉的第三气囊。 在另外的实施例中，具有收缩区域的支架或袖带分别展开在主动脉或其周围，以在支架或袖带的上游产生背压。 还提供了增强肾脏灌注的方法。
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公开(公告)号：US07766892B2
公开(公告)日：2010-08-03
申请号：US10153050
申请日：2002-05-21
申请人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J. Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
发明人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J. Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
IPC分类号： A61M31/00
CPC分类号： A61M25/00 , A61B17/12013 , A61B2017/00243 , A61B2017/061 , A61B2017/22054 , A61F2002/068 , A61M1/101 , A61M1/1018 , A61M1/1034 , A61M1/106 , A61M1/107 , A61M1/1072 , A61M1/1096 , A61M1/122 , A61M1/125 , A61M1/3653 , A61M1/3659 , A61M25/0075 , A61M25/10 , A61M25/1011 , A61M2025/1052 , A61M2210/1082 , A61M2210/125
摘要： Methods and apparatus are provided for treating congestive heart by actively or passively enhancing perfusion to the renal arteries. A first embodiment comprises a specially configured balloon catheter and extracorporeal pump, wherein the pump operates in a “once-through” fashion or alternating volume displacement mode. In another embodiment the catheter includes a pair of balloons to isolate a region of the aorta, and a third balloon that directs flow into the renal arteries. In still further embodiments, a stent or cuff having a constricted region is deployed in or around the aorta, respectively, to create a backpressure upstream of the stent or cuff. Methods of enhancing renal perfusion also are provided.
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公开(公告)号：US06884250B2
公开(公告)日：2005-04-26
申请号：US10237359
申请日：2002-09-09
CPC分类号： A61B17/1114 , A61B2017/00867 , A61B2017/1117 , A61B2017/1132
摘要： An intratubular anastomosis apparatus for joining organ portions of a hollow organ after intussusception which includes an anastomosis ring, and a crimping support element. The anastomosis ring includes a length of a wire formed of a shape memory alloy for crimping adjacent organ portions against the crimping support element so as to cause anastomosis. The anastomosis ring and the shape memory alloy assumes a plastic state, when at a first, lower temperature and an elastic state, when reaching at least a second, higher temperature. The crimping support element provides a support for crimping the organ portions against the support element. Using the anastomosis ring and crimping support element of the present invention reduces the risk of leakage and no staples or sutures remain within the anastomosed organ portion.
摘要翻译： 一种管腔内吻合装置，用于连接包括吻合环的肠套叠后的中空器官的器官部分，以及卷曲支撑元件。 吻合环包括由形状记忆合金形成的线的长度，用于将邻近的器官部分压靠在压接支撑元件上以便进行吻合。 当达到至少第二个较高温度时，当处于第一，较低温度和弹性状态时，吻合环和形状记忆合金呈现塑性状态。 压接支撑元件提供用于将器官部分压靠支撑元件的支撑。 使用本发明的吻合环和压接支撑元件降低了泄漏的风险，并且在吻合的器官部分内不存在钉或缝线。
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公开(公告)号：US07094247B2
公开(公告)日：2006-08-22
申请号：US10237505
申请日：2002-09-09
IPC分类号： A61B17/08
CPC分类号： A61B17/1114 , A61B2017/00867 , A61B2017/1117 , A61B2017/1132
摘要： Apparatus for intratubular intussusception and anastomosis of a hollow organ portion including a cylindrical enclosure, coaxial intratubular intussusception device, for intussusception and clamping means. The apparatus also includes an intratubular anastomosis apparatus for joining organ portions after intussusception thereof with an anastomosis ring and crimping support element. The ring is formed of a shape memory alloy wire, for crimping adjacent organ portions against the crimping support element so as to cause anastomosis therebetween. The ring assumes a plastic or malleable state, at a lower temperature and an elastic state at a higher temperature. The apparatus further includes the crimping support element for intratubular insertion so as to provide a support for crimping the organ portions against the support element. The apparatus additionally includes a surgical excising means, for excising an intussuscepted organ portion, after crimping adjacent intussuscepted organ walls against the crimping support element with the anastomosis ring.
摘要翻译： 用于腔内肠套叠和中空器官部分吻合的装置，包括圆柱形外壳，同轴的管内肠套叠装置，用于套叠和夹紧装置。 该装置还包括用于在肠套叠后的器官部分与吻合环和压接支撑元件接合的管状内吻合装置。 环由形状记忆合金线形成，用于将相邻的器官部分压靠在压接支撑元件上，从而在其间进行吻合。 环在较低的温度和较高的温度下呈弹性状态呈现塑性或延展性状态。 该装置还包括用于颈内插入的压接支撑元件，以便提供用于将器官部分压靠支撑元件的支撑。 该装置还包括手术切除装置，用于在用吻合环将相邻的套叠器官壁压靠在卷曲支撑元件上之后切除肠套叠器官部分。
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公开(公告)号：US08205782B2
公开(公告)日：2012-06-26
申请号：US12373450
申请日：2007-07-12
申请人： Boaz Harari , Leonid Monassevitch , Michael Arad , Doron Kopelman , Amir Perle , Boaz Shenhav , Kobby Greenberg
发明人： Boaz Harari , Leonid Monassevitch , Michael Arad , Doron Kopelman , Amir Perle , Boaz Shenhav , Kobby Greenberg
IPC分类号： A61B17/04
CPC分类号： A61B17/0643 , A61B17/115 , A61B17/32053 , A61B2017/0641
摘要： A compression assembly for use in compressing tissue comprising a first portion which includes a first compression element and a second portion which comprises a second compression element, at least one support element, and at least one spring element. Typically the spring element is formed of a shape-memory material. The at least one spring element is in compressive force contact with the second compression element and the tissue to be joined is positioned between the first and second compression elements. A plurality of needles on one of the support elements is operative to pierce the tissue and the first portion of the assembly, holding the first compression element to the second portion of the assembly. The invention is appropriate for joining severed tissue in anastomosis procedures or closing natural or surgically produced tissue perforations.
摘要翻译： 一种用于压缩组织的压缩组件，包括包括第一压缩元件的第一部分和包括第二压缩元件，至少一个支撑元件和至少一个弹簧元件的第二部分。 通常，弹簧元件由形状记忆材料形成。 所述至少一个弹簧元件与第二压缩元件压缩力接触，并且待连接的组织定位在第一和第二压缩元件之间。 一个支撑元件上的多个针可操作以刺穿组织和组件的第一部分，将第一压缩元件保持在组件的第二部分。 本发明适用于在吻合过程中连接切断的组织或闭合天然或手术产生的组织穿孔。
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公开(公告)号：US07527185B2
公开(公告)日：2009-05-05
申请号：US11485604
申请日：2006-07-12
申请人： Boaz Harari , Leonid Monassevitch , Michael Arad , Doron Kopelman , Amir Perle
发明人： Boaz Harari , Leonid Monassevitch , Michael Arad , Doron Kopelman , Amir Perle
IPC分类号： A61B17/08
CPC分类号： A61B17/115 , A61B17/0643 , A61B17/1155 , A61B17/32053 , A61B2017/0641
摘要： A compression anastomosis ring (CAR) assembly for use in joining severed organ wall portions of a hollow organ. The assembly comprises a first portion which includes an anvil assembly and a second portion which comprises a bottom ring, at least one ring element, and at least one spring element formed of a shape-memory alloy. The at least one spring element provides a restorative force and is in compressive force contact with the bottom ring and the tissue to be joined is positioned between the anvil ring and the bottom ring. A plurality of needles on one of the ring elements is operative, upon application of a closure force, to pierce the tissue and the anvil ring, holding the anvil ring to the second portion of the CAR assembly. An applicator for applying the CAR assembly and a method for using the assembly and applicator are taught.
摘要翻译： 压缩吻合环（CAR）组件，用于连接中空器官的切断的器官壁部分。 组件包括包括砧组件的第一部分和包括底环，至少一个环形元件和由形状记忆合金形成的至少一个弹簧元件的第二部分。 所述至少一个弹簧元件提供修复力并且与所述底环压缩力接触，并且待连接的组织位于所述砧座环和所述底环之间。 一个环形元件上的多个针在施加闭合力时可操作以刺穿组织和砧座环，将砧座环保持在CAR组件的第二部分。 教导了用于施加CAR组件的施加器和使用组件和涂敷器的方法。
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公开(公告)号：US07635374B2
公开(公告)日：2009-12-22
申请号：US11647912
申请日：2006-12-29
申请人： Leonid Monassevitch , Boaz Shenhav , Boaz Harari , Amir Perle , Michael Arad , Shahar Millis , Kobby Greenberg , Alex Geller , Amir Szold , Shlomo Lelcuk , Doron Kopelman , Amol Bapaye , Dror Rosner
发明人： Leonid Monassevitch , Boaz Shenhav , Boaz Harari , Amir Perle , Michael Arad , Shahar Millis , Kobby Greenberg , Alex Geller , Amir Szold , Shlomo Lelcuk , Doron Kopelman , Amol Bapaye , Dror Rosner
CPC分类号： A61B17/0643 , A61B1/00135 , A61B1/0014 , A61B1/018 , A61B17/068 , A61B17/12 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B2017/0641 , A61B2017/308
摘要： A system including surgical compression clips is described and used for endoscopic full thickness resection. Similarly, methods for endoscopic full thickness resection using the described system are also discussed. Surgical compression clips using shape-memory elements are discussed. These clips are advanceable to the site of suspect tissue to be resected through a lumen of a multi-lumen sleeve encasing an endoscope. At the site of the tissue, the compression clip is opened and operated to circumscribe the suspect tissue. Grasper assemblies, advanceable through an endoscope, are also described. These latter grasp and bring the suspect tissue to the open clip. The clip is then closed and the tissue resected. The clip effects necrosis and healing at the resected site.
摘要翻译： 描述了一种包括手术压缩夹的系统，用于内窥镜全厚度切除。 类似地，还讨论了使用所述系统的内窥镜全厚度切除术的方法。 讨论使用形状记忆元件的手术压缩夹。 这些夹子可推进到可疑组织的位置，以通过包围内窥镜的多腔套筒的内腔切除。 在组织的位置处，压缩夹被打开并操作以包围可疑组织。 还描述了可通过内窥镜推进的抓斗组件。 这些后者将把嫌疑组织带到打开的夹子上。 然后关闭夹子并切除组织。 夹子会影响切除部位的坏死和愈合。
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公开(公告)号：US20070213747A1
公开(公告)日：2007-09-13
申请号：US11647913
申请日：2006-12-29
申请人： Leonid Monassevitch , Boaz Shenhav , Boaz Harari , Amir Perle , Michael Arad , Shahar Millis , Kobby Greenberg , Alex Geller , Amir Szold , Shlomo Lelcuk , Doron Kopelman , Amol Bapaye , Dror Rosner
发明人： Leonid Monassevitch , Boaz Shenhav , Boaz Harari , Amir Perle , Michael Arad , Shahar Millis , Kobby Greenberg , Alex Geller , Amir Szold , Shlomo Lelcuk , Doron Kopelman , Amol Bapaye , Dror Rosner
IPC分类号： A61B17/08
CPC分类号： A61B17/12 , A61B1/0014 , A61B17/0643 , A61B17/068 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B2017/00867 , A61B2017/00871 , A61B2017/0641 , A61B2017/308
摘要： A surgical clip assembly which includes a pair of generally linear compression elements for securing tissue between them and for applying to the secured tissue a compression force. The clip assembly has an initial, open position in which the linear compression elements may be positioned about tissue to be secured between them. The assembly also has a final, closed position where the compression elements are substantially parallel to each other, applying a compressive force to the secured tissue. The clip assembly also includes a force means disposed between the pair of compression elements and operative to transmit operational forces between them.
摘要翻译： 一种外科夹子组件，其包括一对大致线性的压缩元件，用于将组织固定在它们之间并用于向固定的组织施加压缩力。 夹子组件具有初始的打开位置，其中线性压缩元件可以围绕组织定位以固定在它们之间。 组件还具有最终的闭合位置，其中压缩元件基本上彼此平行，向固定的组织施加压缩力。 夹子组件还包括设置在该对压缩元件之间并且可操作地在它们之间传递操作力的力装置。
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公开(公告)号：US20100331862A1
公开(公告)日：2010-12-30
申请号：US12521597
申请日：2007-12-27
申请人： Leonid Monassevitch , Boaz Shenhav , Boaz Harari , Amir Perle , Michael Arad , Shahar Millis , Kobby Greenberg , Shlomo Lelcuk , Doron Kopelman , Amol Bapaye , Dror Rosner
发明人： Leonid Monassevitch , Boaz Shenhav , Boaz Harari , Amir Perle , Michael Arad , Shahar Millis , Kobby Greenberg , Shlomo Lelcuk , Doron Kopelman , Amol Bapaye , Dror Rosner
CPC分类号： A61B17/12 , A61B1/0014 , A61B17/0643 , A61B17/068 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B2017/00867 , A61B2017/00871 , A61B2017/0641 , A61B2017/308
摘要： A compression clip system where compression is used to close a tissue opening, reduce the volume of an organ, ligate dilated blood vessels or compress tissue adjacent to various other types of lesions to induce healing. Compression prevents bleeding and the leakage of body fluids into a body cavity. The opening may be surgery induced as in gastrectomies or formed naturally such as peptic ulcers and hemorrhoids. The system may include a compression clip, a suitable clip applier, a grasper assembly and an endoscope all brought to the compression site via a multi-lumen sleeve.
摘要翻译： 压缩夹系统，其中压缩用于封闭组织开口，减少器官的体积，连接扩张的血管或压迫与各种其它类型的损伤相邻的组织以诱导愈合。 压缩防止体液流入体腔的出血和泄漏。 开口可以是胃切除手术或自然形成的手术，如消化性溃疡和痔疮。 该系统可以包括压缩夹，合适的施夹器，抓紧器组件和内窥镜，其全部通过多腔套筒带到压缩部位。
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