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公开(公告)号：US11125695B2
公开(公告)日：2021-09-21
申请号：US16111646
申请日：2018-08-24
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hans-Peter Josel , Herbert Andres , Michaela Windfuhr , Oliver Larbolette , Stefan Quint
IPC: G01N21/76 , G01N21/66 , G01N33/543 , C07F15/00 , G01N27/30
Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.
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公开(公告)号：US11125601B2
公开(公告)日：2021-09-21
申请号：US16226889
申请日：2018-12-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Guenter Ziegler , Oliver Larbolette , Rolf Herb
IPC: G01F23/292 , G01F23/14 , G01F23/24 , G01F23/26 , G01N35/10
Abstract: An apparatus for processing a laboratory sample contained in a laboratory sample container is presented. The apparatus comprises an optical sensing unit for sensing a transmittance at different vertical positions through the laboratory sample container and a tip sensing unit having a tip. The tip sensing unit is adapted to provide a tip sensing signal (tLDS) depending on a position of the tip relative to the sample. The apparatus also comprises a process control unit adapted to control the secure and reliable pipetting of the laboratory sample in response to both the transmittance and the tip sensing signal (tLDS) provided by the tip sensing unit.
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3.发明申请公开(公告)号：US20200003768A1
公开(公告)日：2020-01-02
申请号：US16561284
申请日：2019-09-05
Inventor： Ralf Kraus , Oliver Larbolette , Friedrich Staebler , Yoshihiro y Yamashita , Yukinori Sakashita , Shinya Matsuoka , Michihiro Saito , Taku Sakazume , Katsuaki Takahashi
IPC: G01N33/543 , G01N21/69
Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.
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公开(公告)号：US20180364175A1
公开(公告)日：2018-12-20
申请号：US16111646
申请日：2018-08-24
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hans-Peter Josel , Herbert Andres , Michaela Windfuhr , Oliver Larbolette , Stefan Quint
Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.
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Patent Agency Ranking
5.发明申请公开(公告)号：US20190120682A1
公开(公告)日：2019-04-25
申请号：US16226889
申请日：2018-12-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Guenter Ziegler , Oliver Larbolette , Rolf Herb
IPC: G01F23/292 , G01N35/10
Abstract: An apparatus for processing a laboratory sample contained in a laboratory sample container is presented. The apparatus comprises an optical sensing unit for sensing a transmittance at different vertical positions through the laboratory sample container and a tip sensing unit having a tip. The tip sensing unit is adapted to provide a tip sensing signal (tLDS) depending on a position of the tip relative to the sample. The apparatus also comprises a process control unit adapted to control the processing of the laboratory sample in response to the transmittance and the tip sensing signal (tLDS) provided by the tip sensing unit.
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6.发明申请ELECTROCHEMILUMINESCENCE METHOD OF DETECTING AN ANALYTE IN A LIQUID SAMPLE AND ANALYSIS SYSTEM 有权检测液体样品和分析系统中的分析仪的电致发光方法公开(公告)号：US20160097765A1
公开(公告)日：2016-04-07
申请号：US14968118
申请日：2015-12-14
Inventor： Ralf Kraus , Oliver Larbolette , Friedrich Staebler , Yoshihiro Yamashita , Yukinori Sakashita , Shinya Matsuoka , Michihiro Saito , Taku Sakazume , Kenichi Takahashi
IPC: G01N33/543 , G01N21/69
Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.
Abstract translation: 用于检测液体样品中的分析物的电化学发光法和相应的分析系统。 通过首先将含有包含蛋白质包被的磁性微粒的流体的容器提供到搅拌单元来检测液体样品中的分析物。 流体的搅拌是必需的，因为微粒的密度通常高于缓冲液的密度。 因此，由于弱相互作用，微粒倾向于沉积在容器的底部，导致微粒的聚集。 为了获得代表性的测量，需要在缓冲液中均匀分布微粒以确保每个分析循环的微粒的恒定浓度。 还需要提供微粒的解聚，这也是通过搅拌流体来实现的。 以适合于待搅拌的流体的量的转动频率进行搅拌。
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7.发明公开公开(公告)号：US20230251253A1
公开(公告)日：2023-08-10
申请号：US18300689
申请日：2023-04-14
Inventor： Ralf Kraus , Oliver Larbolette , Friedrich Staebler , Yoshihiro Yamashita , Yukinori Sakashita , Shinya Matsuoka , Michihiro Saito , Taku Sakazume , Katsuaki Takahashi
CPC classification number: G01N33/5438 , G01N33/54326 , G01N21/66 , G01N21/76 , G01N33/54393 , G01N33/582 , G01N35/0098 , G01N21/69 , G01N2035/00534 , G01N2201/12
Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.
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8.发明授权公开(公告)号：US11703504B2
公开(公告)日：2023-07-18
申请号：US16561284
申请日：2019-09-05
Inventor： Ralf Kraus , Oliver Larbolette , Friedrich Staebler , Yoshihiro Yamashita , Yukinori Sakashita , Shinya Matsuoka , Michihiro Saito , Taku Sakazume , Katsuaki Takahashi
CPC classification number: G01N33/5438 , G01N21/66 , G01N21/69 , G01N21/76 , G01N33/54326 , G01N33/54393 , G01N33/582 , G01N35/0098 , G01N2035/00534 , G01N2201/12
Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.
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9.发明授权公开(公告)号：US10422797B2
公开(公告)日：2019-09-24
申请号：US14968118
申请日：2015-12-14
Inventor： Ralf Kraus , Oliver Larbolette , Friedrich Staebler , Yoshihiro Yamashita , Yukinori Sakashita , Shinya Matsuoka , Michihiro Saito , Taku Sakazume , Katsuaki Takahashi
Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.
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