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    Therapeutic uses of complement receptor 2
    3.
    发明授权
    Therapeutic uses of complement receptor 2 失效
    补体受体2的治疗用途

    公开(公告)号：US07378094B2

    公开(公告)日：2008-05-27

    申请号：US10489564

    申请日：2002-08-28

    申请人： Ronald P. Taylor ,  Margaret A. Lindorfer ,  William M. Sutherland

    发明人： Ronald P. Taylor ,  Margaret A. Lindorfer ,  William M. Sutherland

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/08 ,  C07K2317/54

    摘要： The present invention is directed to an immune complex composition, and a method of using that complex to enhance an in viva immune response against a preselected target antigen. The immune complexes of the present invention comprise a monoclonal antibody specific for binding to complement receptor (CR2) site on B lymphocytes linked to a target antigen. As shown in FIG. SA-SD immune complexes bound to monkey B cells are removed in concert with loss of CR2. FIGS. SA and SB demonstrate the % A1488 HB135 and % APhCy CD21 positive cells, out of the doubly positive FE CD20/PerCF CD45 population over time, after injection of A1488 labeled HB135 (an anti-CR2 antibody, administration indicated by first arrow) followed by injection of rabbit anti-mouse IgG (administration indicated by the second arrow). FIGS. SC and SD are plots of the molecules of equivalent soluble fluorochome (MESF) values for these populations.

    摘要翻译： 本发明涉及免疫复合物组合物，以及使用该复合物以增强针对预选靶抗原的血液免疫应答的方法。 本发明的免疫复合物包含对与靶抗原连接的B淋巴细胞上的补体受体（CR2）位点结合有特异性的单克隆抗体。 如图所示。 与猴B细胞结合的SA-SD免疫复合物与CR2的丧失一起被去除。 图 SA和SB在注射A1488标记的HB135（抗CR2抗体，由第一个箭头表示的给药）后，证明了在双倍阳性FE CD20 / PerCF CD45群体中随时间推移的％A1488 HB135和％APhCy CD21阳性细胞， 注射兔抗小鼠IgG（由第二个箭头表示的给药）。 图 SC和SD是这些种群的等效可溶性荧光素（MESF）值分子的图。

    Internal mold release agent for use in reaction injection molding
    5.
    发明授权
    Internal mold release agent for use in reaction injection molding 失效
    用于反应注射成型的内部脱模剂

    公开(公告)号：US4581386A

    公开(公告)日：1986-04-08

    申请号：US737369

    申请日：1985-05-23

    申请人： Ronald P. Taylor ,  Mark E. Cekoric ,  John E. Dewhurst ,  Saad M. Abouzahr

    发明人： Ronald P. Taylor ,  Mark E. Cekoric ,  John E. Dewhurst ,  Saad M. Abouzahr

    IPC分类号： B29C33/60 ,  C08G18/50 ,  C08G18/65 ,  C08K5/098 ,  C08G18/14

    CPC分类号： C08G18/6529 ,  B29C33/60 ,  C08G18/5021 ,  C08K5/098 ,  B29K2075/00 ,  C08G2120/00 ,  C08G2125/00 ,  Y10S264/83

    摘要： The present invention is directed to a process for the production of optionally cellular, polyurethane elastomer molding by reacting a reaction mixture containing(I) a polyisocyanate,(II) an isocyanate-reactive polymer having a molecular weight of about 1800 to 12,000,(III) about 5 to 50% by weight, based on the weight of component (II) of a chain extender comprising a sterically hindered aromatic diamine and(IV) an internal mold release agent mixture comprising(a) about 0.5 to 10% by weight, based on the weight of components (II) and (III) of a zinc carboxylate containing 8 to 24 carbon atoms per carboxylate group and(b) a compatibilizer comprising a member selected from the group consisting of nitrogen-containing, isocyanate-reactive, acyclic compounds and nitrogen-containing, isocyanate-reactive polymers in an amount sufficient to solubilize the zinc carboxylate so that when the internal mold release agent mixture is in admixture with components (II) and (III), the zinc carboxylate possesses improved resistance to precipitation,the reaction mixture being processed as a one-shot system by the RIM process at an isocyanate index of about 70 to 130.

    摘要翻译： 本发明涉及通过使包含（I）多异氰酸酯，（II）分子量为约1800至12,000的异氰酸酯反应性聚合物的反应混合物，（III） ）约5至50重量％，基于包含空间位阻芳族二胺的增链剂组分（II）的重量，和（IV）内部脱模剂混合物，其包含（a）约0.5至10重量％ 基于每个羧酸酯基团含有8至24个碳原子的羧酸锌的组分（II）和（III）的重量，和（b）增容剂，其包含选自含氮，异氰酸酯反应性，非环状 化合物和含氮异氰酸酯反应性聚合物，其量足以溶解羧酸锌，使得当内部脱模剂混合物与组分（II）和（III）混合时，锌羧酸 甲酸酯具有改善的抗沉淀性能，反应混合物通过RIM方法以约70至130的异氰酸酯指数作为单次注射系统加工。

    Polyurethane polyolefins and prepolymers based on hydroxy functional polybutadiene
    7.
    发明授权
    Polyurethane polyolefins and prepolymers based on hydroxy functional polybutadiene 有权
    聚氨酯聚烯烃和基于羟基官能聚丁二烯的预聚物

    公开(公告)号：US5990340A

    公开(公告)日：1999-11-23

    申请号：US223167

    申请日：1998-12-30

    申请人： Karl W. Haider ,  Jack C. Chan ,  E. Haakan Jonsson ,  Uli W. Franz ,  Mark A. Peters ,  Ronald P. Taylor

    发明人： Karl W. Haider ,  Jack C. Chan ,  E. Haakan Jonsson ,  Uli W. Franz ,  Mark A. Peters ,  Ronald P. Taylor

    IPC分类号： C08G18/69 ,  C07C271/08 ,  C08G18/67

    CPC分类号： C08G18/69

    摘要： A di-hydroxy-functionalized linear non-crosslinked polyolefin is disclosed having no pendant chain-branched groups which is prepared by reacting 1,4-diacetoxy-2-butene with 1,5-cyclooctadiene in the presence of a catalyst comprising a ruthenium metal carbene complex, characterized in that the functionality number of said polyolefin as determined by NMR is 2.0 and the viscosity of said polyolefin ranges from about 800 to 16000 mPa.s @25.degree. C. at a number average molecular weight ranging from 2,600 to 6,500 g/mole. A prepolymer comprising the reaction of a polyisocyanate with the polyolefin is also disclosed.

    摘要翻译： 公开了一种二羟基官能化线性非交联聚烯烃，其不具有侧链支链基团，其通过使1,4-二乙酰氧基-2-丁烯与1,5-环辛二烯在催化剂存在下制备，所述催化剂包含钌金属 卡宾络合物，其特征在于通过NMR确定的所述聚烯烃的官能度数为2.0，所述聚烯烃的粘度在25℃至约800至16000mPa.s的数均分子量范围为2600至6,500g /痣。 还公开了包含多异氰酸酯与聚烯烃的反应的预聚物。

    Process and composition for the production of polyurethane elastomer moldings
    8.
    发明授权
    Process and composition for the production of polyurethane elastomer moldings 失效
    用于生产聚氨酯弹性体模制品的工艺和组成

    公开(公告)号：US4442235A

    公开(公告)日：1984-04-10

    申请号：US492923

    申请日：1983-05-09

    申请人： Ronald P. Taylor ,  John E. Dewhurst ,  Saad M. Abouzahr

    发明人： Ronald P. Taylor ,  John E. Dewhurst ,  Saad M. Abouzahr

    IPC分类号： C08G18/32 ,  C08G18/65 ,  C08K5/18 ,  C08G18/14

    CPC分类号： C08G18/6529 ,  C08G18/324 ,  C08K5/18 ,  C08G2120/00

    摘要： The present invention is directed to a process for the production of polyurethane elastomer moldings by reacting a reaction mixture in a closed mold, wherein said reaction mixture comprises:(a) an organic polyisocyanate;(b) an organic active hydrogen group-containing compound having a molecular weight of from 1800 to 12,000 and containing at least two active hydrogen groups;(c) 1,3,5-triethyl-2,6-diamino benzene and, optionally(d) a catalyst for the reaction between hydroxyl groups and isocyanate groups,wherein component (c) is present in an amount of from 25 to 35 percent by weight based on the combined weight of components (b) and (c), wherein the amounts of components (a), (b) and (c) are such that the isocyanate index of the reaction mixture is from about 90 to 110, and wherein all of said components are processed via a one-shot process whereby (a) is mixed simultaneously either with (b), (c) and (d) or with a non-reacted premixture of some or all of (b), (c) and (d).

    摘要翻译： 本发明涉及通过使闭合模具中的反应混合物反应生产聚氨酯弹性体成型体的方法，其中所述反应混合物包括：（a）有机多异氰酸酯; （b）分子量为1800〜12000，含有至少2个活性氢基团的含有机活性氢基团的化合物; （c）1,3,5-三乙基-2,6-二氨基苯和任选地（d）用于羟基和异氰酸酯基之间的反应的催化剂，其中组分（c）的存在量为25至35 基于组分（b）和（c）的组合重量的重量百分数，其中组分（a），（b）和（c）的量使得反应混合物的异氰酸酯指数为约90至110 ，并且其中所有所述组分都通过一步法处理，其中（a）同时与（b），（c）和（d）混合或与（b）的一部分或全部的未反应的预混合物混合， ，（c）和（d）。