公开(公告)号：US12203012B2

公开(公告)日：2025-01-21

申请号：US17055310

申请日：2019-05-14

Applicant: Shiseido Company, Ltd.

Inventor： Chika Tanaka ,  Tomoko Onodera ,  Masaya Takagi ,  Chieko Mizumoto ,  Daisuke Kubota ,  Masahiko Yano

IPC: C09J193/04 ,  A61B10/02 ,  C09J11/06 ,  C09J11/08 ,  G01N1/04 ,  G01N1/40 ,  G01N1/08

Abstract: A stratum corneum-collecting adhesive composition includes a hydrophobic component having adhesiveness, and a hydrophilic component that is present in a dispersed state in the hydrophobic component.

公开(公告)号：US10907208B2

公开(公告)日：2021-02-02

申请号：US16412993

申请日：2019-05-15

Applicant: Shiseido Company, Ltd

Inventor： Yosuke Tojo ,  Masato Iino ,  Chieko Mizumoto ,  Yuzo Yoshida ,  Yuko Matsuura ,  Hisashi Mori

IPC: C12N9/90 ,  C12Q1/6876 ,  G01N33/50 ,  A61K38/01 ,  A61K36/9068 ,  A61K36/28 ,  G01N33/68 ,  C12Q1/6883 ,  A61K36/899 ,  A61K8/9789 ,  A61K8/9794 ,  A61K8/64 ,  A61Q19/00

Abstract: The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.

公开(公告)号：US20160069867A1

公开(公告)日：2016-03-10

申请号：US14477213

申请日：2014-09-04

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Yosuke Tojo ,  Masato lino ,  Chieko Mizumoto ,  Yuzo Yoshida ,  Hisashi Mori

IPC: G01N33/50 ,  A61K36/28 ,  A61K36/9068 ,  C12Q1/68 ,  A61K38/01

CPC classification number: C12Q1/6876 ,  A61K8/645 ,  A61K8/97 ,  A61K36/28 ,  A61K36/899 ,  A61K36/9068 ,  A61K38/011 ,  A61K2800/782 ,  A61Q19/00 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/148 ,  C12Q2600/158 ,  G01N33/5044 ,  G01N33/6812 ,  G01N2333/968 ,  G01N2333/99 ,  G01N2800/20 ,  A61K2300/00

Abstract: The object of the invention is to develop a screening method for drugs having effects of increasing skin barrier function in in vitro experimentation, and to evaluate skin barrier function for skin. Serine racemase activity and/or expression level are used as an indicator to allow screening of candidate drugs.

Abstract translation: 本发明的目的是开发一种在体外实验中具有增加皮肤屏障功能作用的药物的筛选方法，并评估皮肤的皮肤屏障功能。 使用丝氨酸消旋酶活性和/或表达水平作为候选药物筛选的指标。

公开(公告)号：US20150079623A1

公开(公告)日：2015-03-19

申请号：US14385871

申请日：2013-03-18

Applicant: Kyushu University, National University Corporation ,  SHISEIDO COMPANY, LTD.

Inventor： Kenji Hamase ,  Yousuke Toujo ,  Masashi Mita ,  Chieko Mizumoto

IPC: G01N33/68 ,  G06F19/18 ,  G06F19/00 ,  G01N30/88

CPC classification number: G01N33/6806 ,  G01N30/88 ,  G01N2030/8818 ,  G01N2030/8877 ,  G16B20/00 ,  G16H50/30

Abstract: The apparatus for analyzing a disease sample according to the present invention includes: a member for separating and quantitatively determining an amino acid stereoisomer in a biological material from a subject; a member for obtaining a disease state index value through a calculation by substituting the amount of the amino acid stereoisomer into a discriminant equation; and a member for outputting disease state information on the subject on the basis of the disease state index value. The method for analyzing a disease sample according to the present invention includes: a step of measuring the amount of amino acid stereoisomers in a biological material from a subject; a step of obtaining a disease state index value through a calculation by substituting the amount of the amino acid stereoisomers into a discriminant equation; and the like.

Abstract translation: 根据本发明的用于分析疾病样品的装置包括：用于分离和定量测定来自受试者的生物材料中的氨基酸立体异构体的成员; 通过将氨基酸立体异构体的量代入判别方程式的计算来获得疾病状态指标值的成员; 以及基于疾病状态指标值输出关于受试者的疾病状态信息的成员。 根据本发明的用于分析疾病样品的方法包括：测量来自受试者的生物材料中氨基酸立体异构体的量的步骤; 通过将氨基酸立体异构体的量代入判别式来计算得到疾病状态指标值的步骤; 等等。

公开(公告)号：US12243652B2

公开(公告)日：2025-03-04

申请号：US17414519

申请日：2019-12-19

Applicant: Shiseido Company, Ltd.

Inventor： Chieko Mizumoto ,  Satoshi Amano ,  Seiji Satoh ,  Naoto Hanyu ,  Chie Yasuda

IPC: G16H50/70 ,  A45D44/00 ,  A61B5/00 ,  G06Q30/0601 ,  G06Q50/00 ,  G16B20/20 ,  G16H10/40 ,  G16H10/60 ,  G16H50/30 ,  G16H80/00

Abstract: Provided are a counseling method and counseling device which present a skincare advice appropriate to a user. The counseling device includes an obtaining unit that obtains genetic information representing a result of a genetic test on a user and stratum corneum information representing a result of a stratum corneum test on the user; a skin constitution determining unit that determines skin constitution of the user, based on the genetic information; a skin capability determining unit that determines skin capability representing a skin condition of the user, based on the stratum corneum information; an identifying unit that identifies a skincare advice and/or a cosmetic to be proposed to the user, based on the skin constitution and the skin capability; and a presenting unit that presents counseling information including information on the skincare advice and/or cosmetic to the user.

公开(公告)号：US10337064B2

公开(公告)日：2019-07-02

申请号：US15123274

申请日：2015-03-05

Applicant: Shiseido Company, Ltd

Inventor： Yosuke Tojo ,  Masato Iino ,  Chieko Mizumoto ,  Yuzo Yoshida ,  Yuko Matsuura ,  Hisashi Mori

IPC: A61K8/64 ,  C12N9/90 ,  C12Q1/6876 ,  G01N33/50 ,  A61K38/01 ,  A61K36/9068 ,  A61K36/28 ,  G01N33/68 ,  C12Q1/6883 ,  A61K36/899 ,  A61K8/97 ,  A61Q19/00

Abstract: The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.

公开(公告)号：US20190025320A1

公开(公告)日：2019-01-24

申请号：US16137968

申请日：2018-09-21

Applicant: Shiseido Company, Ltd.

Inventor： Kenji Hamase ,  Yousuke Toujo ,  Masashi Mita ,  Chieko Mizumoto

IPC: G01N33/68 ,  G16H50/30 ,  G06F19/18 ,  G01N30/88

Abstract: The apparatus for analyzing a disease sample according to the present invention includes: a member for separating and quantitatively determining an amino acid stereoisomer in a biological material from a subject; a member for obtaining a disease state index value through a calculation by substituting the amount of the amino acid stereoisomer into a discriminant equation; and a member for outputting disease state information on the subject on the basis of the disease state index value. The method for analyzing a disease sample according to the present invention includes: a step of measuring the amount of amino acid stereoisomers in a biological material from a subject; a step of obtaining a disease state index value through a calculation by substituting the amount of the amino acid stereoisomers into a discriminant equation; and the like.