公开(公告)号：US11311585B2

公开(公告)日：2022-04-26

申请号：US16764573

申请日：2018-11-15

Applicant: Shiseido Company, Ltd.

Inventor： Kentaro Kajiya ,  Yuuko Matsumoto

IPC: A61K36/06 ,  A61K36/254 ,  A61K36/28 ,  A61K36/64

Abstract: The purpose of the present invention is to provide a substance related to the stabilization of capillary blood vessels. This invention is based on the discovery that an extract from a plant selected from the group consisting of Calendula officinalis, Siberian ginseng, and Cistanche salsa increases gene expression of VE-cadherin or integrin α5.

公开(公告)号：US11213472B2

公开(公告)日：2022-01-04

申请号：US16827033

申请日：2020-03-23

Applicant: Shiseido Company, Ltd.

Inventor： Mio Nakamura ,  Kentaro Kajiya ,  Shinichiro Haze

IPC: A61K36/00 ,  A61K8/49 ,  A61K36/61 ,  A61K8/37 ,  A61Q19/08 ,  A61K31/22 ,  A61K31/351 ,  A61K8/92 ,  A61K36/738 ,  A61Q19/06 ,  A61K31/122 ,  A61Q19/10 ,  A61Q19/00

Abstract: The purpose of this invention is to find a novel fragrance component effective for prevention or control of swelling, lymphedema, skin aging or obesity from the viewpoint of activation of lymph vessel function by promotion of the expression of VEGFC. This invention provides a swelling improving agent, lymph vessel activator and VEGFC production promoter characterized by containing one or a plurality of components selected from the group consisting of rose oxide, citronellyl acetate and niaouli oil.

公开(公告)号：US10718782B2

公开(公告)日：2020-07-21

申请号：US15897455

申请日：2018-02-15

Applicant: Shiseido Company, Ltd. ,  ETH Zurich

Inventor： Yuzo Yoshida ,  Kentaro Kajiya ,  Michael Detmar

IPC: G01N33/68 ,  G01N33/50 ,  C12Q1/6881

Abstract: The present invention relates to a method of evaluating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in a harvested skin sample, and a method of evaluating a drug for improving, preventing or treating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in cultured cells.

公开(公告)号：US20190195753A1

公开(公告)日：2019-06-27

申请号：US16324349

申请日：2017-08-10

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Kentaro Kajiya ,  Toyonobu YAMASHITA

IPC: G01N1/30 ,  C12N5/071

CPC classification number: G01N1/30 ,  C12N5/0698 ,  G01N1/28

Abstract: The present invention address the problem of providing a transparent skin sample by removing epidermis via enzymatic treatment.

公开(公告)号：US20180196064A1

公开(公告)日：2018-07-12

申请号：US15897455

申请日：2018-02-15

Applicant: Shiseido Company, Ltd. ,  ETH Zurich

Inventor： Yuzo Yoshida ,  Kentaro Kajiya ,  Michael Detmar

IPC: G01N33/68 ,  C12Q1/6881 ,  G01N33/50

CPC classification number: G01N33/6881 ,  C12Q1/6881 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5044 ,  G01N2333/4703 ,  G01N2500/10 ,  G01N2800/20

Abstract: The present invention relates to a method of evaluating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in a harvested skin sample, and a method of evaluating a drug for improving, preventing or treating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in cultured cells.