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公开(公告)号：US10718782B2
公开(公告)日：2020-07-21
申请号：US15897455
申请日：2018-02-15
申请人： Shiseido Company, Ltd. , ETH Zurich
发明人： Yuzo Yoshida , Kentaro Kajiya , Michael Detmar
IPC分类号： G01N33/68 , G01N33/50 , C12Q1/6881
摘要： The present invention relates to a method of evaluating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in a harvested skin sample, and a method of evaluating a drug for improving, preventing or treating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in cultured cells.
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公开(公告)号：US20180196064A1
公开(公告)日：2018-07-12
申请号：US15897455
申请日：2018-02-15
申请人： Shiseido Company, Ltd. , ETH Zurich
发明人： Yuzo Yoshida , Kentaro Kajiya , Michael Detmar
IPC分类号： G01N33/68 , C12Q1/6881 , G01N33/50
CPC分类号： G01N33/6881 , C12Q1/6881 , C12Q2600/136 , C12Q2600/158 , G01N33/5044 , G01N2333/4703 , G01N2500/10 , G01N2800/20
摘要： The present invention relates to a method of evaluating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in a harvested skin sample, and a method of evaluating a drug for improving, preventing or treating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in cultured cells.
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公开(公告)号：US20170313982A1
公开(公告)日：2017-11-02
申请号：US15643869
申请日：2017-07-07
发明人： Haruyo Yamanishi , Tsutomu Soma , Yuzo Yoshida
IPC分类号： C12N5/071
CPC分类号： C12N5/0625 , C12N5/0628 , C12N2500/90 , C12N2501/135
摘要： The problem to be solved by the present invention is to provide a serum-free medium suitable for culturing of DS cells. The present invention relates to a serum-free medium for culturing of DS cells containing platelet-derived growth factor (PDGF), or to a method for culturing of dermal sheath (DS) cells, using serum-free medium comprising PDGF.
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公开(公告)号：US11427807B2
公开(公告)日：2022-08-30
申请号：US15643869
申请日：2017-07-07
发明人： Haruyo Yamanishi , Tsutomu Soma , Yuzo Yoshida
IPC分类号： C12N5/071
摘要： The present disclosure relates to a serum-free medium for culturing of DS cells containing platelet derived growth factor (PDGF), or to a method for culturing of dermal sheath (DS) cells, using serum-free medium comprising PDGF.
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公开(公告)号：US10337064B2
公开(公告)日：2019-07-02
申请号：US15123274
申请日：2015-03-05
发明人： Yosuke Tojo , Masato Iino , Chieko Mizumoto , Yuzo Yoshida , Yuko Matsuura , Hisashi Mori
IPC分类号： A61K8/64 , C12N9/90 , C12Q1/6876 , G01N33/50 , A61K38/01 , A61K36/9068 , A61K36/28 , G01N33/68 , C12Q1/6883 , A61K36/899 , A61K8/97 , A61Q19/00
摘要： The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.
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公开(公告)号：US10907208B2
公开(公告)日：2021-02-02
申请号：US16412993
申请日：2019-05-15
发明人： Yosuke Tojo , Masato Iino , Chieko Mizumoto , Yuzo Yoshida , Yuko Matsuura , Hisashi Mori
IPC分类号： C12N9/90 , C12Q1/6876 , G01N33/50 , A61K38/01 , A61K36/9068 , A61K36/28 , G01N33/68 , C12Q1/6883 , A61K36/899 , A61K8/9789 , A61K8/9794 , A61K8/64 , A61Q19/00
摘要： The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.
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公开(公告)号：US10172332B2
公开(公告)日：2019-01-08
申请号：US15076836
申请日：2016-03-22
发明人： Yuzo Yoshida , Tsutomu Soma , Shigeyoshi Fujiwara
IPC分类号： A01N63/00 , A01N65/00 , C12N5/071 , A01K67/027 , A61K35/36 , A61L27/38 , A61K8/98 , A61Q7/00 , C12N5/0775
摘要： Provided is a method for regenerating hair follicles by transplanting a composition containing CD36-expressing dermal sheath cells (DSc) to a human. The composition may be prepared by sorting CD36-expressing dermal sheath cells from a hair follicle tissue by use of a cell-sorting technique along with an antibody to CD36. The composition may also contain dermal papilla cells (DPc).
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8.发明申请METHOD FOR SCREENING SKIN BARRIER FUNCTION ENHANCING AGENT BASED ON EPIDERMAL SERINE RACEMASE AND/OR D-SERINE LEVEL, AND SKIN BARRIER FUNCTION EVALUATION METHOD 审中-公开基于EPIDERMAL SERINE RACEMASE和/或D-丝氨酸水平筛选皮肤屏障功能增强剂的方法和皮肤屏障功能评估方法公开(公告)号：US20160069867A1
公开(公告)日：2016-03-10
申请号：US14477213
申请日：2014-09-04
发明人： Yosuke Tojo , Masato lino , Chieko Mizumoto , Yuzo Yoshida , Hisashi Mori
IPC分类号： G01N33/50 , A61K36/28 , A61K36/9068 , C12Q1/68 , A61K38/01
CPC分类号： C12Q1/6876 , A61K8/645 , A61K8/97 , A61K36/28 , A61K36/899 , A61K36/9068 , A61K38/011 , A61K2800/782 , A61Q19/00 , C12Q1/6883 , C12Q2600/136 , C12Q2600/148 , C12Q2600/158 , G01N33/5044 , G01N33/6812 , G01N2333/968 , G01N2333/99 , G01N2800/20 , A61K2300/00
摘要： The object of the invention is to develop a screening method for drugs having effects of increasing skin barrier function in in vitro experimentation, and to evaluate skin barrier function for skin. Serine racemase activity and/or expression level are used as an indicator to allow screening of candidate drugs.
摘要翻译： 本发明的目的是开发一种在体外实验中具有增加皮肤屏障功能作用的药物的筛选方法，并评估皮肤的皮肤屏障功能。 使用丝氨酸消旋酶活性和/或表达水平作为候选药物筛选的指标。
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