公开(公告)号：US12215124B2

公开(公告)日：2025-02-04

申请号：US16969879

申请日：2019-02-20

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Ronald Graham ,  Andrew Spaventa ,  Eli Glezer

IPC: C07H21/04 ,  C12Q1/6869

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

公开(公告)号：US11773439B2

公开(公告)日：2023-10-03

申请号：US18052798

申请日：2022-11-04

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Andrew Spaventa ,  David Barker

IPC: C12Q1/6869 ,  C07H21/04 ,  C12Q1/6867

CPC classification number: C12Q1/6869 ,  C07H21/04 ,  C12Q1/6867 ,  C12Q2521/101 ,  C12Q2525/185 ,  C12Q2525/186 ,  C12Q2535/00

Abstract: The present disclosure provides improved nucleic acid sequencing-by-synthesis (SBS) methods, related kits and reagents, and systems for performing such methods using such kits and reagents.

公开(公告)号：US20220298201A1

公开(公告)日：2022-09-22

申请号：US16969879

申请日：2019-02-20

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Ronald Graham ,  Andrew Spaventa ,  Eli Glezer

IPC: C07H21/04 ,  C12Q1/6869

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

公开(公告)号：US12110515B2

公开(公告)日：2024-10-08

申请号：US18048388

申请日：2022-10-20

Applicant: Singular Genomics Systems, Inc.

Inventor： Souad Naji ,  Carl W. Fuller ,  Eli N. Glezer ,  Andrew Spaventa

IPC: C12N9/12 ,  C12N15/10 ,  C12Q1/6874

CPC classification number: C12N9/1252 ,  C12N15/102 ,  C12Q1/6874 ,  C12Y207/07007

Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Thermococcus sp. EP1 that exhibit improved incorporation of nucleotide analogues utilized in DNA sequences.

公开(公告)号：US20250084120A1

公开(公告)日：2025-03-13

申请号：US18948143

申请日：2024-11-14

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Andrew Spaventa ,  Eli N. Glezer

IPC: C07H21/04 ,  C12Q1/6869

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

公开(公告)号：US20240101979A1

公开(公告)日：2024-03-28

申请号：US18500785

申请日：2023-11-02

Applicant: Singular Genomics Systems, Inc.

Inventor： Souad Naji ,  Carl W. Fuller ,  Eli N. Glezer ,  Andrew Spaventa

IPC: C12N9/12 ,  C12P19/34

CPC classification number: C12N9/1252 ,  C12P19/34 ,  C12Y207/07007

Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.

公开(公告)号：US11512295B2

公开(公告)日：2022-11-29

申请号：US17017578

申请日：2020-09-10

Applicant: Singular Genomics Systems, Inc.

Inventor： Souad Naji ,  Carl W. Fuller ,  Eli N. Glezer ,  Andrew Spaventa

IPC: C12N9/12 ,  C12N15/10 ,  C12Q1/6874

Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Thermococcus sp. EP1 that exhibit improved incorporation of nucleotide analogues utilized in DNA sequences.

公开(公告)号：US20220161251A1

公开(公告)日：2022-05-26

申请号：US17531488

申请日：2021-11-19

Applicant: Singular Genomics Systems, Inc.

Inventor： Andrew Spaventa ,  Christian Berrios ,  Eli N. Glezer ,  Zachary Terranova

IPC: B01L3/00 ,  G01N33/483 ,  G01N33/487 ,  G01N33/53 ,  B64C39/02

Abstract: Disclosed herein, inter alfa, are systems and methods for contactless evaluation of a biological sample.

公开(公告)号：US11845923B2

公开(公告)日：2023-12-19

申请号：US17369593

申请日：2021-07-07

Applicant: Singular Genomics Systems, Inc.

Inventor： Souad Naji ,  Carl W. Fuller ,  Eli Glezer ,  Andrew Spaventa

IPC: C12N9/12 ,  C12P19/34

CPC classification number: C12N9/1252 ,  C12P19/34 ,  C12Y207/07007

Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.

公开(公告)号：US11591647B2

公开(公告)日：2023-02-28

申请号：US16492076

申请日：2018-03-06

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Eli Glezer ,  Andrew Spaventa ,  David Barker

IPC: C12Q1/6869 ,  C07H21/04 ,  C12Q1/6867

Abstract: The present disclosure provides improved nucleic acid sequencing-by-synthesis (SBS) methods, related kits and reagents, and systems for performing such methods using such kits and reagents.