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公开(公告)号：US20130045500A1
公开(公告)日：2013-02-21
申请号：US13212817
申请日：2011-08-18
IPC分类号： C12Q1/02
CPC分类号： G01N33/5011
摘要： The present invention provides a method of figuring out an effect of a medicine exerting on the same cell quantitatively over a time. A cell evaluation method includes a step of culturing cells on a cell-culture base material that is capable of culturing spheroids, and a step of measuring a change over a time in the number of the spheroids formed through the former step or a percentage of the spheroids formed through the former step relative to an entire cultured cell.
摘要翻译： 本发明提供一种在一定时间内定量地计算出在同一细胞上施用的药物的效果的方法。 细胞评价方法包括在能够培养球体的细胞培养基材上培养细胞的步骤，以及测定通过前述步骤形成的球状体数目的时间变化的步骤，或者 相对于整个培养细胞，通过前一步形成的球体。
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公开(公告)号：US20090074800A1
公开(公告)日：2009-03-19
申请号：US12155864
申请日：2008-06-11
CPC分类号： G01N33/57419 , A61K39/00 , C07K14/4748 , G01N33/57438
摘要： An object of the present invention to provide: a human pancreatic cancer antigen and/or a human colon cancer antigen that can be applied to the diagnosis and/or treatment of various types of cancers or tumors including pancreatic cancer and colon cancer as representative examples; a gene encoding the same; an anti-cancer vaccine using the same; or the like. The present invention provides a cancer antigen comprising a protein having the amino acid sequence shown in SEQ ID NO: 1; a peptide comprising a portion of said protein and having immune-stimulating activity; an anti-cancer vaccine comprising said peptide; a DNA having the nucleotide sequence shown in SEQ ID NO: 2, or its complementary sequence or a part or full length of these sequence; an anti-cancer vaccine comprising said DNA; and use thereof.
摘要翻译： 本发明的目的是提供：可用于诊断和/或治疗包括胰腺癌和结肠癌的各种类型的癌症或肿瘤的人胰腺癌抗原和/或人结肠癌抗原作为代表性实例; 编码该基因的基因; 使用其的抗癌疫苗; 或类似物。 本发明提供包含具有SEQ ID NO：1所示氨基酸序列的蛋白质的癌抗原; 包含所述蛋白质的一部分并具有免疫刺激活性的肽; 包含所述肽的抗癌疫苗; 具有SEQ ID NO：2所示核苷酸序列的DNA或其互补序列或这些序列的部分或全长; 包含所述DNA的抗癌疫苗; 及其用途。
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3.发明授权Glypican-3 (GPC3)-derived tumor rejection antigenic peptides useful for HLA-A2-positive patients and pharmaceutical comprising the same 有权可用于HLA-A2阳性患者的磷脂酰肌醇蛋白聚糖-3（GPC3）衍生的肿瘤排斥抗原肽和包含其的药物公开(公告)号：US08053556B2
公开(公告)日：2011-11-08
申请号：US12063165
申请日：2006-08-08
IPC分类号： C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K31/00 , A61K38/00 , A61K39/00 , A61K39/38 , A61K49/00 , C07H21/04
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/4725
摘要： It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an immunotherapy which is able to target approximately 40% of Japanese patients suffering from several types of cancers, which express GPC3 at a high level. The present invention provides a peptide of any of the following (A) or (B): (A) a peptide, which has the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3; or (B) a peptide, which has an amino acid sequence comprising a substitution or addition of one or two amino acids with respect to the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has ability to induce killer T cells.
摘要翻译： 本发明的目的是鉴定可与HLA-A2结合并激活人类杀伤T细胞的磷脂酰肌醇蛋白聚糖-3衍生肽，以提供进行免疫治疗的手段，该免疫治疗能够靶向约40％ 患有几种类型癌症的日本患者，其高水平表达GPC3。 本发明提供下述（A）或（B）中任一项所述的肽：（A）具有SEQ ID NO：1〜3中任一项所示的氨基酸序列的肽; 或（B）肽，其具有相对于SEQ ID NO：1至3中任一项所示的氨基酸序列取代或添加一个或两个氨基酸的氨基酸序列，并且其具有 诱导杀伤T细胞。
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公开(公告)号：US08017345B2
公开(公告)日：2011-09-13
申请号：US11577435
申请日：2005-08-09
IPC分类号： G01N33/53 , G01N33/48 , G01N33/567 , C12Q1/68
CPC分类号： G01N33/5743 , G01N2333/4722 , G01N2333/4727
摘要： The object of the present invention is to find out another tumor marker which is useful for early diagnosis of melanoma, and provide a diagnostic kit and diagnostic method for malignant melanoma using such marker. The present invention provides a diagnostic kit for malignant melanoma, which comprises an antibody against SPARC and an antibody against GPC3.
摘要翻译： 本发明的目的是找出可用于黑色素瘤早期诊断的另一种肿瘤标志物，并提供使用这种标记物的恶性黑素瘤的诊断试剂盒和诊断方法。 本发明提供了用于恶性黑素瘤的诊断试剂盒，其包含针对SPARC的抗体和针对GPC3的抗体。
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公开(公告)号：US20080044818A1
公开(公告)日：2008-02-21
申请号：US10577343
申请日：2004-10-28
IPC分类号： C12Q1/68
CPC分类号： G01N33/5743
摘要： An object of the present invention is to provide a novel and clinically useful diagnostic agent for malignant melanoma. The present invention provides a diagnostic agent for malignant melanoma, which comprises an antibody against GPC3, or a probe or a primer capable of detecting GPC3 expression.
摘要翻译： 本发明的目的是提供一种用于恶性黑素瘤的新型临床有用的诊断剂。 本发明提供了一种恶性黑素瘤诊断剂，其包含抗GPC 3的抗体或能够检测GPC 3表达的探针或引物。
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6.发明授权Glypican-3 (GPC3)-derived tumor rejection antigenic peptides useful for HLA-A2-positive patients and pharmaceutical comprising the same 有权可用于HLA-A2阳性患者的磷脂酰肌醇蛋白聚糖-3（GPC3）衍生的肿瘤排斥抗原肽和包含其的药物公开(公告)号：US08535942B2
公开(公告)日：2013-09-17
申请号：US13242019
申请日：2011-09-23
IPC分类号： C12N5/00 , C12N5/02 , C12N5/08 , A61K39/38 , A61K39/385
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/4725
摘要： It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an immunotherapy which is able to target approximately 40% of Japanese patients suffering from several types of cancers, which express GPC3 at a high level. The present invention provides a peptide of any of the following (A) or (B): (A) a peptide, which has the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3; or (B) a peptide, which has an amino acid sequence comprising a substitution or addition of one or two amino acids with respect to the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has ability to induce killer T cells.
摘要翻译： 本发明的目的是鉴定可与HLA-A2结合并激活人类杀伤T细胞的磷脂酰肌醇蛋白聚糖-3衍生肽，以提供进行免疫治疗的手段，该免疫治疗能够靶向约40％ 患有几种类型癌症的日本患者，其高水平表达GPC3。 本发明提供下述（A）或（B）中任一项所述的肽：（A）具有SEQ ID NO：1〜3中任一项所示的氨基酸序列的肽; 或（B）肽，其具有相对于SEQ ID NO：1至3中任一项所示的氨基酸序列取代或添加一个或两个氨基酸的氨基酸序列，并且其具有 诱导杀伤T细胞。
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公开(公告)号：US20090111095A1
公开(公告)日：2009-04-30
申请号：US11577435
申请日：2005-08-09
CPC分类号： G01N33/5743 , G01N2333/4722 , G01N2333/4727
摘要： The object of the present invention is to find out another tumor marker which is useful for early diagnosis of melanoma, and provide a diagnostic kit and diagnostic method for malignant melanoma using such marker. The present invention provides a diagnostic kit for malignant melanoma, which comprises an antibody against SPARC and an antibody against GPC3.
摘要翻译： 本发明的目的是找出可用于黑色素瘤早期诊断的另一种肿瘤标志物，并提供使用这种标记物的恶性黑素瘤的诊断试剂盒和诊断方法。 本发明提供了用于恶性黑素瘤的诊断试剂盒，其包含针对SPARC的抗体和针对GPC3的抗体。
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公开(公告)号：US09404925B2
公开(公告)日：2016-08-02
申请号：US12155864
申请日：2008-06-11
CPC分类号： G01N33/57419 , A61K39/00 , C07K14/4748 , G01N33/57438
摘要： An object of the present invention to provide: a human pancreatic cancer antigen and/or a human colon cancer antigen that can be applied to the diagnosis and/or treatment of various types of cancers or tumors including pancreatic cancer and colon cancer as representative examples; a gene encoding the same; an anti-cancer vaccine using the same; or the like. The present invention provides a cancer antigen comprising a protein having the amino acid sequence shown in SEQ ID NO: 1; a peptide comprising a portion of said protein and having immune-stimulating activity; an anti-cancer vaccine comprising said peptide; a DNA having the nucleotide sequence shown in SEQ ID NO: 2, or its complementary sequence or a part or full length of these sequence; an anti-cancer vaccine comprising said DNA; and use thereof.
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公开(公告)号：US07803533B2
公开(公告)日：2010-09-28
申请号：US10577343
申请日：2004-10-28
IPC分类号： C12Q1/68
CPC分类号： G01N33/5743
摘要： An object of the present invention is to provide a novel and clinically useful diagnostic agent for malignant melanoma. The present invention provides a diagnostic agent for malignant melanoma, which comprises an antibody against GPC3, or a probe or a primer capable of detecting GPC3 expression.
摘要翻译： 本发明的目的是提供一种用于恶性黑素瘤的新型临床有用的诊断剂。 本发明提供了一种恶性黑素瘤诊断剂，其包含抗GPC3抗体或能够检测GPC3表达的探针或引物。
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10.发明申请GLYPICAN-3 (GPC3)-DERIVED TUMOR REJECTION ANTIGENIC PEPTIDES USEFUL FOR HLA-A2-POSITIVE PATIENTS AND PHARMACEUTICAL COMPRISING THE SAME 有权用于HLA-A2阳性患者和包含其的药物的GLYPICAN-3（GPC3）有效的肿瘤抑制抗原肽公开(公告)号：US20090239806A1
公开(公告)日：2009-09-24
申请号：US12063165
申请日：2006-08-08
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/4725
摘要： It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an immunotherapy which is able to target approximately 40% of Japanese patients suffering from several types of cancers, which express GPC3 at a high level. The present invention provides a peptide of any of the following (A) or (B): (A) a peptide, which has the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3; or (B) a peptide, which has an amino acid sequence comprising a substitution or addition of one or two amino acids with respect to the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has ability to induce killer T cells.
摘要翻译： 本发明的目的是鉴定可与HLA-A2结合并激活人类杀伤T细胞的磷脂酰肌醇蛋白聚糖-3衍生肽，以提供进行免疫治疗的手段，该免疫治疗能够靶向约40％ 患有几种类型癌症的日本患者，其高水平表达GPC3。 本发明提供下述（A）或（B）中任一项所述的肽：（A）具有SEQ ID NO：1〜3中任一项所示的氨基酸序列的肽; 或（B）肽，其具有相对于SEQ ID NO：1至3中任一项所示的氨基酸序列取代或添加一个或两个氨基酸的氨基酸序列，并且其具有 诱导杀伤T细胞。
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