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    Novel Combination of Compounds to be Used in the Treatment of Airway Diseases, Especially Chronic Obstructive Pulmonary Disease (COPD) and Asthma
    6.
    发明申请
    Novel Combination of Compounds to be Used in the Treatment of Airway Diseases, Especially Chronic Obstructive Pulmonary Disease (COPD) and Asthma 审中-公开
    用于治疗气道疾病，特别是慢性阻塞性肺疾病（COPD）和哮喘的化合物的新型组合

    公开(公告)号：US20110124613A1

    公开(公告)日：2011-05-26

    申请号：US12527754

    申请日：2008-02-21

    申请人： Tomas Eriksson ,  Johan Hansson ,  Marguerite Mensonides-Harsema ,  John Mo

    发明人： Tomas Eriksson ,  Johan Hansson ,  Marguerite Mensonides-Harsema ,  John Mo

    IPC分类号： A61K31/438 ,  C07D491/10 ,  C07D471/10 ,  A61K31/56 ,  A61P11/00 ,  A61P11/06

    CPC分类号： A61K31/438 ,  A61K31/569 ,  C07D471/10 ,  C07D491/10

    摘要： The present invention provides a pharmaceutical product comprising, in combination of, (a) a (therapeutically effective) dose of a first active ingredient, which is a compound of formula (I) or a pharmaceutically acceptable salt thereof; and (b) a (therapeutically effective) dose of a second active ingredient, which is a glucocorticoid receptor agonist; and optionally, (c) a (therapeutically effective) dose of a third active ingredient, which is a β2-agonist. The invention further relates to pharmaceutical compositions comprising said combination and to methods of treating treatment of airway diseases, especially chronic obstructive pulmonary disease (COPD) and asthma in mammals by administrating said combination. The invention further relates to a kit comprising the combination and use of said kit in treatment of airway diseases such as COPD and asthma.

    摘要翻译： 本发明提供了包含（a）（治疗有效）剂量的第一活性成分（其为式（I）化合物或其药学上可接受的盐）的药物产品， 和（b）（治疗有效的）剂量的第二活性成分，其是糖皮质激素受体激动剂; 和（c）（治疗有效的）剂量的第三种活性成分，其是一种2-激动剂。 本发明还涉及包含所述组合的药物组合物和通过施用所述组合来治疗气道疾病，特别是慢性阻塞性肺疾病（COPD）和哺乳动物哮喘的治疗方法。 本发明还涉及包含所述试剂盒在治疗气道疾病如COPD和哮喘中的组合和用途的试剂盒。