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公开(公告)号：US20080167332A1
公开(公告)日：2008-07-10
申请号：US11779700
申请日：2007-07-18
申请人： Scott Gibson , Barry Elkins , Mike Rogers , Ian Hassall , Hong Gu , Zhenyu Wang , Vinod Kumar , Synthana Suresh Kumar , Santosh Kavitake , Sidda Lingesha , Eric Merifield , David Ennis , John Pavey , Austen Pimm , James Reuberson , Bo-Goran Josefsson , Martin Hemmerling , Svetlana Ivanova , Marguerite Mensonides-Harsema , Hakan Schulz , John Mo , Tomas Eriksson , Per Strandberg
发明人： Scott Gibson , Barry Elkins , Mike Rogers , Ian Hassall , Hong Gu , Zhenyu Wang , Vinod Kumar , Synthana Suresh Kumar , Santosh Kavitake , Sidda Lingesha , Eric Merifield , David Ennis , John Pavey , Austen Pimm , James Reuberson , Bo-Goran Josefsson , Martin Hemmerling , Svetlana Ivanova , Marguerite Mensonides-Harsema , Hakan Schulz , John Mo , Tomas Eriksson , Per Strandberg
IPC分类号： A61K31/438 , A61P11/00 , C07D491/107 , C07C275/32 , C07D211/52 , C07C69/76 , C07C69/52 , C07C233/81 , C07C233/00 , C07D303/46 , A61P29/00
CPC分类号： C07C233/25 , C07C69/92 , C07C235/60 , C07D211/48 , C07D303/23 , C07D491/107
摘要： Compounds of formula (I) wherein R1, R3, R4, R5, R6, R7, and R10 are as defined in the specification, are described. The present invention also relates to pharmaceutical composition comprising said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof. Beside, the invention relates to salts and polymorphic forms of the new compounds as well as the preparation thereof.
摘要翻译： 式（I）的化合物，其中R 1，R 3，R 4，R 5，R SUP > 6 ，R＆lt; 7＆gt;和＆lt; 10＆gt;如说明书中所定义。 本发明还涉及包含所述化合物的药物组合物和所述化合物在治疗中的用途。 本发明还涉及制备所述化合物的方法和可用于其制备的新中间体。 除此之外，本发明涉及新化合物的盐和多晶型物及其制备。
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2.发明申请Novel Tricyclic Spiropiperidine Compounds, Their Synthesis and Their Uses as Modulators of Chemokine Receptor Activity 审中-公开新型三环哌啶化合物，其合成及其用途作为趋化因子受体活性的调节剂公开(公告)号：US20090176815A1
公开(公告)日：2009-07-09
申请号：US12355478
申请日：2009-01-16
申请人： Tomas Eriksson , Martin Hemmerling , Bo-Goran Josefsson , Svetlana Ivanova , Marguerite Mensonides-Harsema , John Mo , John Pavey , Austen Pimm , James Reuberson , Hakan Schulz , Per Strandberg
发明人： Tomas Eriksson , Martin Hemmerling , Bo-Goran Josefsson , Svetlana Ivanova , Marguerite Mensonides-Harsema , John Mo , John Pavey , Austen Pimm , James Reuberson , Hakan Schulz , Per Strandberg
IPC分类号： A61K31/438 , C07D491/107 , A61P11/00
CPC分类号： C07C233/25 , C07C69/92 , C07C235/60 , C07D211/48 , C07D303/23 , C07D491/107
摘要： Compounds of formula (I) wherein R1, R3, R4, R5, R6, R7, and R10 are as defined in the specification, are described. The present invention also relates to pharmaceutical composition comprising said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof. Beside, the invention relates to salts and polymorphic forms of the new compounds as well as the preparation thereof.
摘要翻译： 描述了其中R 1，R 3，R 4，R 5，R 6，R 7和R 10如说明书中所定义的式（I）化合物。 本发明还涉及包含所述化合物的药物组合物和所述化合物在治疗中的用途。 本发明还涉及制备所述化合物的方法和可用于其制备的新中间体。 除此之外，本发明涉及新化合物的盐和多晶型物及其制备方法。
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公开(公告)号：US20070129393A1
公开(公告)日：2007-06-07
申请号：US10579545
申请日：2004-11-15
申请人： Andrew Baxter , Nafizal Hossain , Svetlana Ivanova , Marguerite Mensonides-Harsema , Austen Pimm , James Reuberson
发明人： Andrew Baxter , Nafizal Hossain , Svetlana Ivanova , Marguerite Mensonides-Harsema , Austen Pimm , James Reuberson
IPC分类号： A61K31/44
CPC分类号： C07D491/10
摘要： The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, t, R3, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物，其中m，R 1，n，R 2，q，X，Y，Z，t，R 3， R SUP，R 4，R 5，R 6，R 7和R 8， / SUP>如本说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US07498338B2
公开(公告)日：2009-03-03
申请号：US10579545
申请日：2004-11-15
申请人： Andrew Baxter , Nafizal Hossain , Svetlana Ivanova , Marguerite Mensonides-Harsema , Austen Pimm , James Reuberson
发明人： Andrew Baxter , Nafizal Hossain , Svetlana Ivanova , Marguerite Mensonides-Harsema , Austen Pimm , James Reuberson
IPC分类号： A61K31/438 , C07D491/107
CPC分类号： C07D491/10
摘要： The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, t, R3, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物，其中m，R1，n，R2，q，X，Y，Z，t，R3，R4，R5，R6，R7和R8如说明书中所定义， ，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20050245741A1
公开(公告)日：2005-11-03
申请号：US10520699
申请日：2003-07-07
IPC分类号： C07D491/10 , A61K31/403 , A61K31/407 , A61K31/438 , A61K31/4747 , A61K31/527 , A61K31/5386 , A61P11/00 , A61P11/06 , A61P19/02 , A61P25/00 , A61P25/26 , A61P29/00 , A61P43/00 , C07D20060101 , C07D209/54 , C07D221/20 , C07D471/10 , C07D491/107 , C07D491/113
CPC分类号： C07D221/20 , C07D491/10 , Y02P20/55
摘要： The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, R3, R4, R5, R6, R7, R8, t and R9 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物，其中m，R 1，n，R 2，q，X，Y，Z，R 3 O R 4，R 5，R 6，R 7，R 8，R 8， >，t和R 9如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20090062322A1
公开(公告)日：2009-03-05
申请号：US12265251
申请日：2008-11-05
IPC分类号： A61K31/438 , C07D491/107 , A61P37/00 , A61P11/00 , A61P29/00
CPC分类号： C07D221/20 , C07D491/10 , Y02P20/55
摘要： The invention provides compounds of formula (I) wherein m R1, n, R2, q, X, Y, Z, R3, R4, R5, R6, R7, R8, t, and R9 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物，其中m R1，n，R2，q，X，Y，Z，R3，R4，R5，R6，R7，R8，t和R9如说明书中所定义， 其制剂，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US07449475B2
公开(公告)日：2008-11-11
申请号：US10520699
申请日：2003-07-07
IPC分类号： A61K31/438 , C07D491/107
CPC分类号： C07D221/20 , C07D491/10 , Y02P20/55
摘要： The invention provides compounds of formula (I) wherein m R1, n, R2, q, X, Y, Z, R3, R4, R5, R6, R7, R8, t, and R9 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）的化合物，其中m R 1，n，R 2，q，X，Y，Z，R 3， R 4，R 5，R 6，R 7，R 8， ，t和R 9如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20070123543A1
公开(公告)日：2007-05-31
申请号：US10581171
申请日：2004-11-30
IPC分类号： A61K31/517 , A61K31/506 , C07D491/04
CPC分类号： C07D491/10
摘要： The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, R3, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物，其中m，R 1，n，R 2，q，X，Y，R 3， R 4，R 5，R 6，R 7和R 8都是 如本说明书中所定义的，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20100197644A1
公开(公告)日：2010-08-05
申请号：US12643504
申请日：2009-12-21
申请人： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrecher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
发明人： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrecher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
IPC分类号： A61K31/56 , A61K31/5377 , A61K31/501 , A61K31/506 , A61K31/4709 , A61K31/4439 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/422 , A61K31/4196 , A61K31/4184 , A61K31/4178 , A61K31/416 , C07D413/10 , C07D403/04 , C07D403/12 , C07D215/12 , C07D401/12 , C07D271/02 , C07D417/12 , C07D277/587 , C07D263/38 , C07D263/40 , C07D249/12 , C07D235/26 , C07D233/90 , C07D231/56 , A61P29/00 , A61P11/06
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译： 式（I）化合物：本发明涉及新的吲唑基酯或酰胺衍生物，包含这些衍生物的药物组合物，制备这种新衍生物的方法以及使用这些衍生物作为药物
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公开(公告)号：US20120252770A1
公开(公告)日：2012-10-04
申请号：US13429177
申请日：2012-03-23
申请人： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrencher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
发明人： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrencher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
IPC分类号： A61K31/416 , A61K31/5377 , A61K31/501 , A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/422 , A61K31/4196 , A61K31/4184 , C07D413/10 , C07D401/04 , C07D471/04 , C07D401/12 , C07D417/12 , C07D413/12 , A61K31/4192 , C07D231/56 , A61P29/00 , A61P11/06 , A61P11/00 , C07D405/12 , C07D403/12 , C07D409/12 , C07D417/14 , A61K31/56
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译： 式（I）化合物：本发明涉及新的吲唑基酯或酰胺衍生物，包含这些衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物
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