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公开(公告)号：US20200040040A1
公开(公告)日：2020-02-06
申请号：US16297895
申请日：2019-03-11
申请人： Seqirus UK Limited
发明人： Samuel Ho , David Parker , Peter Fekkes , Ivna De Souza , Peter Mason , Pirada Suphaphiphat
IPC分类号： C07K14/005 , C12N7/00 , A61K39/12
摘要： Disclosed herein are methods for increasing protein yield and cellular productivity. Chemical agents facilitate host cell production of biological molecules to increase product yield.
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公开(公告)号：US20180236058A1
公开(公告)日：2018-08-23
申请号：US15784575
申请日：2017-10-16
申请人： Seqirus UK Limited
发明人： Philip DORMITZER , Michael Franti , Peter Mason
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/525 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151 , C12N2760/16222 , C12N2760/16234 , C12N2760/16251 , C12N2800/24 , C12N2830/00
摘要： The invention provides various reverse genetics systems for producing segmented RNA viruses, wherein the systems do not require bacteria for propagation of all of their expression constructs.
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公开(公告)号：US09574181B2
公开(公告)日：2017-02-21
申请号：US14522747
申请日：2014-10-24
申请人： Seqirus UK Limited
发明人： Heidi Trusheim , Peter Mason , Michael Franti , Björn Keiner , Melissa Sackal , Juerg Hunziker , David Morrissey , François Jean-Charles Natt
IPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , C12N15/113 , A61K39/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K2039/525 , C12N15/1131 , C12N2310/14 , C12N2320/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152
摘要： Methods for producing reassortant viruses are provided wherein the transcription and/or translation of the hemagglutinin and/or neuraminidase genes are suppressed.
摘要翻译： 提供了产生重配病毒的方法，其中抑制了血凝素和/或神经氨酸酶基因的转录和/或翻译。
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公开(公告)号：US11897918B2
公开(公告)日：2024-02-13
申请号：US16297895
申请日：2019-03-11
申请人： Seqirus UK Limited
发明人： Samuel Ho , David Parker , Peter Fekkes , Ivna De Souza , Peter Mason , Pirada Allen
IPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , C12N7/02 , C12N7/00 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , C12N7/00 , C12N7/02 , A61K39/00 , A61K2039/575 , C12N2760/16111 , C12N2760/16134 , C12N2760/16143 , C12N2760/16151 , C12N2760/16234 , C12N2760/16243 , C12N2760/16251
摘要： Disclosed herein are methods for increasing protein yield and cellular productivity. Chemical agents facilitate host cell production of biological molecules to increase product yield.
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公开(公告)号：US10030231B2
公开(公告)日：2018-07-24
申请号：US14762439
申请日：2014-01-23
发明人： Philip Dormitzer , Peter Mason , Pirada Suphaphiphat , Daniel Gibson , David Wentworth , Timothy Stockwell , John Glass
IPC分类号： C12N7/00 , A61K39/145 , C07K14/005 , C12N5/071 , A61K39/00
摘要： Improved methods for the production of reassortant influenza viruses are provided.
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公开(公告)号：US09708585B2
公开(公告)日：2017-07-18
申请号：US14648886
申请日：2013-12-02
IPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , C12N7/00 , C12N2760/16121 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152
摘要： New influenza donor strains for the production of reassortant influenza A viruses are provided.
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公开(公告)号：US20190284575A1
公开(公告)日：2019-09-19
申请号：US16261955
申请日：2019-01-30
申请人： Seqirus UK Limited
发明人： Philip Dormitzer , Michael Franti , Pirada Suphaphiphat , Peter Mason , Bjoern Keiner , Stefania Crotta
IPC分类号： C12N15/86 , A61K39/12 , C12N7/00 , C12N15/85 , A61K39/145
摘要： Expression of a transgene is driven in a host cell using a pol I promoter which is not endogenous to an organism from the same taxonomic order from which the host cell is derived.
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公开(公告)号：US10232031B2
公开(公告)日：2019-03-19
申请号：US14775066
申请日：2014-03-13
IPC分类号： A61K39/145 , A61K39/12 , C12N7/00
摘要： New influenza donor strains for the production of reassortant influenza B viruses are provided.
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