Pharmaceutical compositions containing certain ascorbic acid derivatives
useful in the prophylaxis and treatment of disorders of the circulatory
system
    1.
    发明授权
    Pharmaceutical compositions containing certain ascorbic acid derivatives useful in the prophylaxis and treatment of disorders of the circulatory system 失效
    含有某些可用于预防和治疗循环系统疾病的抗坏血酸衍生物的药物组合物

    公开(公告)号:US4959362A

    公开(公告)日:1990-09-25

    申请号:US245943

    申请日:1988-09-19

    摘要: An ascorbic acid derivative of the formula: ##STR1## wherein R.sup.1 is organic residue having molecular weight of from 15 to 700, R.sup.2 is hydrogen or hydroxyl, R.sup.3 is hydrogen, acyl, optionally substituted phosphono or sulfo, and R.sup.3 and hydroxyl or R.sup.2 may form acetal residue or ketal residue, and a salt thereof are provided.The compound [I] and salts thereof have antioxidant activity and excellent prophylactic and improving actions on disorders of circulatory functions, and they are usefule as antioxidant agent for food and as agents of prophylaxis and improvement of circulatory functional disorders.

    摘要翻译: 一种下式的抗坏血酸衍生物:其中R1是分子量为15-700的有机残基,R2是氢或羟基,R3是氢,酰基,任选取代的膦酰基或磺基,R3和羟基 或R2可以形成缩醛残基或缩酮残基,并提供其盐。 化合物[I]及其盐具有抗氧化活性和对循环功能紊乱的优异的预防和改善作用,并且它们作为食品的抗氧化剂和用作预防和改善循环功能障碍的药物。

    4-Hydroxy-3-pyrrolin-2-ones and treatment of circulatory disorders
therewith
    2.
    发明授权
    4-Hydroxy-3-pyrrolin-2-ones and treatment of circulatory disorders therewith 失效
    4-羟基-3-吡咯啉-2-酮及其循环系统疾病的治疗

    公开(公告)号:US4925868A

    公开(公告)日:1990-05-15

    申请号:US84177

    申请日:1987-08-12

    摘要: The present invention relates to a compound of the formula: ##STR1## wherein X is sulfur or optionally substituted imino group; Y is a bond, oxygen, phenylene, phenyleneoxy, or oxyphenyleneoxy; R.sup.1 is hydrogen or optionally substituted hydrocarbon residue; R.sup.2 is optionally substituted hydrocarbon residue; and R.sup.1 may form, together with the imino-nitrogen atom as X, a nitrogen-containing 5- to 7-membered ring, production and use thereof.The compound (I) of the present invention has an anti-oxidation activity and activities of preventing or improving functional disorders due to biologically active oxygen species, thus being useful as a pharmaceutical agent for prophylaxis and therapy of disorders in the circulatory system.

    摘要翻译: 本发明涉及下式的化合物:其中X是硫或任选取代的亚氨基; Y是键,氧,亚苯基,亚苯氧基或氧亚苯氧基; R1是氢或任选取代的烃残基; R2是任选取代的烃残基; 并且R 1可以与亚氨基氮原子一起形成含氮的5-至7-元环,其生产和使用。 本发明的化合物(I)具有防止或改善由于生物活性氧物质引起的功能障碍的抗氧化活性和活性,因此可用作预防和治疗循环系统疾病的药剂。

    Hydroxybutenolide derivatives, production and use thereof
    4.
    发明授权
    Hydroxybutenolide derivatives, production and use thereof 失效
    羟基丁烯醇内酯衍生物,其生产和使用

    公开(公告)号:US4939274A

    公开(公告)日:1990-07-03

    申请号:US390230

    申请日:1989-08-07

    CPC分类号: C07D307/62 C07D307/60

    摘要: The present invention relates to a compound of the formula: ##STR1## wherein Y is a chemical bond, oxygen atom, phenyleneoxy, or oxyphenyleneoxy; R.sup.1 is hydrogen or hydrocarbon residue; and R.sup.2 is hydrocarbon residue having two or more carbon atoms, production and use thereof.The compound (I) of the present invention has an antioxidation activity and activities of preventing or improving functional disorders due to biologically active oxygen species, thus being useful as a pharmaceutical agent for prophylaxis and therapy of disorders in the circulatory system.

    摘要翻译: 本发明涉及下式的化合物:其中Y是化学键,氧原子,亚苯基氧基或氧代亚苯基氧基; R1是氢或烃残基; R2是具有2个以上碳原子的烃残基,其生产和使用。 本发明的化合物(I)具有抗氧化活性和预防或改善由于生物活性氧物质引起的功能障碍的活性,因此可用作预防和治疗循环系统疾病的药剂。

    Forceps and forceps unit
    5.
    发明授权

    公开(公告)号:US10188415B2

    公开(公告)日:2019-01-29

    申请号:US14122177

    申请日:2011-08-12

    摘要: Forceps include a tubular shaft, an inserted member, a gripping portion, a handle, and a fixing portion. The inserted member is a rod-like member that is inserted inside the tubular shaft and is movable in an axial direction inside the tubular shaft. The gripping portion is provided at a distal end of the inserted member and is coupled to a distal end of the tubular shaft. The handle is coupled to a terminal end of the inserted member. The fixing portion detachably fixes the handle to the tubular shaft in a state where the handle is coupled to the inserted member. The distal end of the tubular shaft has a larger diameter than the diameter of a main body of the tubular shaft. A joint portion, having a smaller diameter than the diameter of the main body of the tubular shaft, is formed at the terminal end of the inserted member. The handle is provided with a joint receptacle that houses the joint portion and is advanced and retracted by manipulation of the handle.

    Method for making upper and lower molds and an apparatus therefor
    6.
    发明授权
    Method for making upper and lower molds and an apparatus therefor 有权
    制造上模和下模的方法及其装置

    公开(公告)号:US08567478B2

    公开(公告)日:2013-10-29

    申请号:US13647947

    申请日:2012-10-09

    IPC分类号: B22C15/00

    摘要: The purpose of this invention is to provide a method for making upper and lower molds and an apparatus therefor that can prevent the resulting molds from being warped and match-plates from being broken.The method of this invention comprises the step of holding a match-plate 1 between cope and drag flasks 2 and 3, inserting upper and lower squeezing means 4 and 5 into the respective openings of the cope and drag flasks 2 and 3, which openings are opposite to the match-plate 1, so as to define upper and lower molding spaces, supplying molding sand to the upper and lower molding spaces, and then causing the upper and lower squeezing means 4 and 5 to move forward to the match-plate 1 so as to squeeze the molding sand and make upper and lower molds, wherein during the step of causing the upper and lower squeezing means to move forward to the match-plate the difference between the squeezing pressures of the upper and lower molding spaces is kept within a predetermined tolerance.

    摘要翻译: 本发明的目的是提供一种用于制造上模和下模的方法及其装置,其可以防止所得模具翘曲,并且匹配板不被破坏。 本发明的方法包括在上下砂箱2和3之间保持配合板1的步骤,将上下压榨装置4和5插入上盖和下砂箱2和3的相应开口中,这些开口是 与匹配板1相对,以便限定上下成型空间,向上下成型空间提供型砂,然后使上下挤压装置4和5向前移动到配合板1 以挤压型砂并制成上模和下模,其中在使上下挤压装置向前移动到匹配板的步骤期间,上,下成型空间的挤压压力之间的差保持在 一个预定的公差。

    Method for Making Upper and Lower Molds and an Apparatus Therefor
    7.
    发明申请
    Method for Making Upper and Lower Molds and an Apparatus Therefor 有权
    制造上下模具的方法及其设备

    公开(公告)号:US20130118703A1

    公开(公告)日:2013-05-16

    申请号:US13647947

    申请日:2012-10-09

    IPC分类号: B22C9/02

    摘要: The purpose of this invention is to provide a method for making upper and lower molds and an apparatus therefor that can prevent the resulting molds from being warped and match-plates from being broken.The method of this invention comprises the step of holding a match-plate 1 between cope and drag flasks 2 and 3, inserting upper and lower squeezing means 4 and 5 into the respective openings of the cope and drag flasks 2 and 3, which openings are opposite to the match-plate 1, so as to define upper and lower molding spaces, supplying molding sand to the upper and lower molding spaces, and then causing the upper and lower squeezing means 4 and 5 to move forward to the match-plate 1 so as to squeeze the molding sand and make upper and lower molds, wherein during the step of causing the upper and lower squeezing means to move forward to the match-plate the difference between the squeezing pressures of the upper and lower molding spaces is kept within a predetermined tolerance.

    摘要翻译: 本发明的目的是提供一种用于制造上模和下模的方法及其装置,其可以防止所得模具翘曲,并且匹配板不被破坏。 本发明的方法包括在上下砂箱2和3之间保持配合板1的步骤,将上下压榨装置4和5插入上盖和下砂箱2和3的相应开口中,这些开口是 与匹配板1相对,以便限定上下成型空间,向上下成型空间提供型砂,然后使上下挤压装置4和5向前移动到配合板1 以挤压型砂并制成上模和下模,其中在使上下挤压装置向前移动到匹配板的步骤期间,上,下成型空间的挤压压力之间的差保持在 一个预定的公差。

    Core-setting method and apparatus for a molding apparatus for producing flaskless molds
    8.
    发明授权
    Core-setting method and apparatus for a molding apparatus for producing flaskless molds 有权
    用于生产无棚模具的成型装置的芯设置方法和装置

    公开(公告)号:US08230898B2

    公开(公告)日:2012-07-31

    申请号:US12744471

    申请日:2008-11-26

    IPC分类号: B22D33/04

    摘要: These inventions provide a method and an apparatus for setting a core used in a molding apparatus that produces flaskless molds, wherein the core-setting apparatus has a simple structure and the accuracy of the positioning of the core while setting it on the lower mold is improved. The inventions comprise: moving a first carrier 52 carrying a core-handling tool 51 which is holding the core 70 toward the cope flask 2 by means of a second carrier 53 when the cope flask 2 is located at the mold-stripping mechanism 12 being lifted to a lifted position by means of a flask-rotation mechanism 13; transferring the first carrier and the core-handling tool to the cope flask which is at the lifted position; lowering the cope flask 2, the core-handling tool 51, and the first carrier 52 by means of the flask-rotation mechanism 13 so that the core 70 comes close to or contacts the lower mold; and releasing the core 70 from the core-handling tool 51 to set the core on the lower mold.

    摘要翻译: 这些发明提供了一种用于设置用于制造无棚模具的成型装置中的芯的方法和装置,其中,芯设置装置具有简单的结构,并且在将芯放置在下模上时芯的定位精度得到改善 。 本发明包括:当上砂箱2位于剥离机构12被提升时,通过第二载体53移动携带芯处理工具51的第一载体52,芯处理工具51将芯70保持在上砂箱2上 通过烧瓶旋转机构13到提升位置; 将第一载体和芯处理工具转移到处于提升位置的上砂箱; 通过烧瓶旋转机构13降低上砂箱2,芯处理工具51和第一托架52,使得芯70靠近或接触下模; 并且将芯70从芯处理工具51释放以将芯设置在下模上。

    Flaskless molding method
    9.
    发明授权
    Flaskless molding method 有权
    无卤成型法

    公开(公告)号:US08056605B2

    公开(公告)日:2011-11-15

    申请号:US11913624

    申请日:2006-05-10

    IPC分类号: B22C9/00 B22C15/02 B22C15/24

    CPC分类号: B22C11/10 B22C15/28

    摘要: A flaskless molding method, wherein a match plate (5) is held between an upper flask (2) and a lower flask (3) and squeeze plates (6) and (7) are inserted into the openings of the upper flask (2) and the lower flask (3) to form an upper manufacturing space and a lower manufacturing space with initial volumes. A foundry sand is filled in the upper and lower manufacturing spaces with the initial volumes through the supply ports of the flask (2) and (3) (first filling). Next, the squeeze plates (6) and (7) are retreated to expand the upper and lower manufacturing spaces more than the initial volumes. The foundry sand is filled again in the expanded upper and lower manufacturing spaces through the supply ports (second filling). After the second filling is completed, the squeeze plates (6) and (7) are advanced to compress the foundry sand in the upper and lower manufacturing spaces so as to manufacture the upper and the lower flasks stacked on each other.

    摘要翻译: 在上烧瓶(2)和下烧瓶(3)之间夹持有匹配板(5)和挤压板(6)和(7)的无烧瓶成型方法插入上烧瓶(2)的开口中, 和下烧瓶(3)以形成上制造空间和具有初始体积的较低制造空间。 通过烧瓶(2)和(3)(第一次填充)的供应口将初始体积填充在上下制造空间中的铸造砂。 接下来,挤压板(6)和(7)被退回以使上部和下部制造空间比初始体积更大。 铸造砂再次通过供应口(第二次填充)填充在扩展的上下制造空间中。 在第二次填充完成之后,挤压板(6)和(7)前进以压缩上下制造空间中的铸造砂,以便制造彼此堆叠的上下烧瓶。

    Molding machine
    10.
    发明授权
    Molding machine 有权
    成型机

    公开(公告)号:US07594531B2

    公开(公告)日:2009-09-29

    申请号:US11826135

    申请日:2007-07-12

    IPC分类号: B22C15/08 B22D46/00

    CPC分类号: B22C11/00 B22C15/08

    摘要: A hydraulic power unit 15 of a match-plate molding machine comprises a hydraulic pump 20 for supplying oil, a piping system 21, 25, and 26 that fluidly communicates with first and second hydraulic cylinder systems 7 and 10 for supplying the oil from the hydraulic pump 20 to them to perform a squeeze step, an accumulator 22 that is provided within the piping system, first and second electromagnetic directional control valves 23 and 24 for controlling the flow of the oil from the hydraulic pump 20 to the first and second hydraulic cylinder systems 7 and 10, first and second pressure sensors 27 and 28 for measuring pressures of the oil of the first and second hydraulic cylinder systems 7 and 10, and for generating output signals that correspond to the measured value, and a controller 29 for receiving the output signals from the first and second pressure sensors 23 and 24, and for controlling the turns of the first and second electromagnetic directional control valves 23 and 24 based on the output signals and the predetermined value within a range below the pressure holding the accumulator 22 against the oil.

    摘要翻译: 配对成型机的液压动力单元15包括用于供给油的液压泵20,与第一和第二液压缸系统7和10流体连通的管道系统21,25和26,用于从液压供给油 泵20进行挤压步骤,设置在管道系统内的蓄能器22,第一和第二电磁方向控制阀23和24,用于控制油从液压泵20流到第一和第二液压缸 系统7和10,用于测量第一和第二液压缸系统7和10的油的压力并用于产生与测量值对应的输出信号的第一和第二压力传感器27和28,以及用于接收 来自第一和第二压力传感器23和24的输出信号,并且用于基于第一和第二压力传感器23和24控制第一和第二电磁方向控制阀23和24的转弯 e输出信号和在低于保持蓄能器22抵抗油的压力的范围内的预定值。