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    METHODS, SYSTEMS, AND COMPOSITIONS FOR NEURONAL DIFFERENTIATION OF MULTIPOTENT STROMAL CELLS
    5.
    发明申请
    METHODS, SYSTEMS, AND COMPOSITIONS FOR NEURONAL DIFFERENTIATION OF MULTIPOTENT STROMAL CELLS 有权
    用于多重结构细胞神经元分化的方法，系统和组合物

    公开(公告)号：US20120148550A1

    公开(公告)日：2012-06-14

    申请号：US13377558

    申请日：2010-06-10

    申请人： Chaya Brodie ,  Shimon Slavin

    发明人： Chaya Brodie ,  Shimon Slavin

    IPC分类号： A61K35/30 ,  A61P25/00 ,  A61P25/28 ,  C12N5/02

    摘要： Some embodiments of the invention comprise methods, systems, and compositions to selectively induce, whether in vitro or in vivo, the neuronal differentiation of multipotent stromal cells through the application of microRNAs, including but not limited to miRNA-124, miRNA-137 and/or miRNA-9* expression products of those miRNAs, and molecules and compositions containing functional elements of those miRNAs. Some embodiments of the invention also comprise the therapeutic administration and use of such induced cells to treat mammalian injuries and diseases, including but not limited to, nervous system injuries or diseases that may otherwise result in decreased cell or system function.

    摘要翻译： 本发明的一些实施方案包括方法，系统和组合物，其通过应用微小RNA（包括但不限于miRNA-124，miRNA-137和/或核糖体）选择性地诱导多潜能基质细胞的体外或体内神经元分化， 或miRNA-9 *表达产物，以及含有这些miRNA功能元件的分子和组合物。 本发明的一些实施方案还包括治疗性施用和使用这种诱导的细胞来治疗哺乳动物的损伤和疾病，包括但不限于神经系统损伤或可能导致细胞或系统功能降低的疾病。

    Methods, systems, and compositions for neuronal differentiation of multipotent stromal cells
    6.
    发明授权
    Methods, systems, and compositions for neuronal differentiation of multipotent stromal cells 有权

    公开(公告)号：US10421961B2

    公开(公告)日：2019-09-24

    申请号：US13377558

    申请日：2010-06-10

    申请人： Chaya Brodie ,  Shimon Slavin

    发明人： Chaya Brodie ,  Shimon Slavin

    IPC分类号： C12N15/113 ,  C12N5/0793 ,  A61K31/7105

    摘要： Some embodiments of the invention comprise methods, systems, and compositions to selectively induce, whether in vitro or in vivo, the neuronal differentiation of multipotent stromal cells through the application of microRNAs, including but not limited to miRNA-124, miRNA-137 and/or miRNA-9* expression products of those miRNAs, and molecules and compositions containing functional elements of those miRNAs. Some embodiments of the invention also comprise the therapeutic administration and use of such induced cells to treat mammalian injuries and diseases, including but not limited to, nervous system injuries or diseases that may otherwise result in decreased cell or system function.

    METHODS OF GENERATING OLIGODENDROCYTES AND CELL POPULATIONS COMPRISING SAME
    7.
    发明申请
    METHODS OF GENERATING OLIGODENDROCYTES AND CELL POPULATIONS COMPRISING SAME 有权
    产生含有寡糖的小鼠和细胞群体的方法

    公开(公告)号：US20130149288A1

    公开(公告)日：2013-06-13

    申请号：US13817535

    申请日：2011-08-14

    申请人： Shimon Slavin ,  Chaya Brodie

    发明人： Shimon Slavin ,  Chaya Brodie

    IPC分类号： C12N5/079

    CPC分类号： C12N5/0622 ,  A61K35/12 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/30 ,  C12N2330/10 ,  C12N2500/25 ,  C12N2501/39 ,  C12N2501/65 ,  C12N2506/025 ,  C12N2506/1353 ,  C12N2506/1384 ,  C12N2506/1392

    摘要： A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (MSCs) with at least one exogenous miRNA having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 15-19 and 27-35, thereby generating the population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells. MSCs differentiated by miRs may also secrete miRs and deliver them to adjacent cells and therefore provide important signals to neighboring endogenous normal or malignant cells.

    摘要翻译： 公开了一种产生可用于治疗受试者脑部疾病的细胞群的方法。 所述方法包括使间充质干细胞（MSC）与至少一种外源miRNA接触，所述外源miRNA具有与选自SEQ ID NO：15-19和27-35的序列至少90％相同的核酸序列，从而产生 细胞群和/或产生神经营养因子，其可以向受损组织或局部驻留的干细胞提供重要信号。 通过miR分化的MSC也可以分泌miR并将其递送至相邻细胞，并因此向相邻内源性正常或恶性细胞提供重要信号。

    Methods and reagents for diagnosing and treating gliomas
    8.
    发明申请
    Methods and reagents for diagnosing and treating gliomas 审中-公开
    诊断和治疗胶质瘤的方法和试剂

    公开(公告)号：US20060216731A1

    公开(公告)日：2006-09-28

    申请号：US11322242

    申请日：2006-01-03

    申请人： Chaya Brodie

    发明人： Chaya Brodie

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6886 ,  A01K2217/052 ,  A61K31/00 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/57484

    摘要： Methods and reagents for diagnosing and treating gliomas. The disclosed methods and reagents rely upon measurement or regulation of RTVP-1 in cells of the central nervous system. Also disclosed is an RTVP gene promoter, cells transformed with such vectors and transgenic animals with at least one exogenous copy of the promoter in their genomes are further disclosed.

    摘要翻译： 诊断和治疗胶质瘤的方法和试剂。 所公开的方法和试剂依赖于中枢神经系统细胞中RTVP-1的测量或调节。 还公开了RTVP基因启动子，进一步公开了用这些载体转化的细胞和在其基因组中具有启动子的至少一个外源拷贝的转基因动物。