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1.发明申请AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 审中-公开氨基三唑基吡啶类，其组合物及其处理方法公开(公告)号：US20130005707A1
公开(公告)日：2013-01-03
申请号：US13609412
申请日：2012-09-11
申请人： Sogole Bahmanyar , R.J. Bates , Kate Blease , Andrew Antony Calabrese , Thomas Oran Daniel , Mercedes Delgado , Jan Elsner , Paul Erdman , Bruce Fahr , Gregory Ferguson , Branden Lee , Lisa Nadolny , Garrick Packard , Patrick Papa , Veronique Plantevin-Krenitsky , Jennifer Riggs , Patricia Rohane , Sabita Sankar , John Sapienza , Yoshitaka Satoh , Victor Sloan , Randall Stevens , Lida Tehrani , Jayashree Tikhe , Eduardo Torres , Andrew Wallace , Brandon Wade Whitefield , Jingjing Zhao
发明人： Sogole Bahmanyar , R.J. Bates , Kate Blease , Andrew Antony Calabrese , Thomas Oran Daniel , Mercedes Delgado , Jan Elsner , Paul Erdman , Bruce Fahr , Gregory Ferguson , Branden Lee , Lisa Nadolny , Garrick Packard , Patrick Papa , Veronique Plantevin-Krenitsky , Jennifer Riggs , Patricia Rohane , Sabita Sankar , John Sapienza , Yoshitaka Satoh , Victor Sloan , Randall Stevens , Lida Tehrani , Jayashree Tikhe , Eduardo Torres , Andrew Wallace , Brandon Wade Whitefield , Jingjing Zhao
IPC分类号： A61K31/437 , A61K31/5377 , A61K31/506 , A61K31/4545 , A61K31/496 , A61K31/551 , A61P37/00 , A61P37/08 , A61P29/00 , A61P7/02 , A61P35/00 , A61P31/00 , A61P25/28 , A61P9/00 , A61P3/00 , A61P37/06 , A61P19/02 , A61P17/00 , A61P31/12 , A61P3/10 , A61P25/00 , A61P21/04 , A61P1/00 , A61P11/02 , A61P11/00 , A61P17/06 , A61P3/04 , A61P19/06 , A61P9/10 , C12N5/071 , A61K31/4709
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.
摘要翻译： 本文提供了式（I）的杂芳基化合物：其中R 1和R 2如本文所定义，包含有效量的杂芳基化合物的组合物和用于治疗或预防炎性病症或癌症的方法，以及可通过抑制激酶治疗或预防的病症 或激酶途径，其包括向有需要的受试者施用有效量的杂芳基化合物。
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2.发明申请AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权氨基三唑基吡啶类，其组合物及其处理方法公开(公告)号：US20100093698A1
公开(公告)日：2010-04-15
申请号：US12555018
申请日：2009-09-08
申请人： Sogole Bahmanyar , R.J. Bates , Kate Blease , Andrew Antony Calabrese , Thomas Oran Daniel , Mercedes Delgado , Jan Elsner , Paul Erdman , Bruce Fahr , Gregory Ferguson , Branden Lee , Lisa Nadolny , Garrick Packard , Patrick Papa , Veronique Plantevin-Krenitsky , Jennifer Riggs , Patricia Rohane , Sabita Sankar , John Sapienza , Yoshitaka Satoh , Victor Sloan , Randall Stevens , Lida Tehrani , Jayashree Tikhe , Eduardo Torres , Andrew Wallace , Brandon Wade Whitefield , Jingjing Zhao
发明人： Sogole Bahmanyar , R.J. Bates , Kate Blease , Andrew Antony Calabrese , Thomas Oran Daniel , Mercedes Delgado , Jan Elsner , Paul Erdman , Bruce Fahr , Gregory Ferguson , Branden Lee , Lisa Nadolny , Garrick Packard , Patrick Papa , Veronique Plantevin-Krenitsky , Jennifer Riggs , Patricia Rohane , Sabita Sankar , John Sapienza , Yoshitaka Satoh , Victor Sloan , Randall Stevens , Lida Tehrani , Jayashree Tikhe , Eduardo Torres , Andrew Wallace , Brandon Wade Whitefield , Jingjing Zhao
IPC分类号： A61K31/437 , C07D471/02 , A61K31/5377 , A61K31/497 , A61K31/55
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.
摘要翻译： 本文提供了式（I）的杂芳基化合物：其中R 1和R 2如本文所定义，包含有效量的杂芳基化合物的组合物和用于治疗或预防炎性病症或癌症的方法，以及可通过抑制激酶治疗或预防的病症 或激酶途径，其包括向有需要的受试者施用有效量的杂芳基化合物。
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3.发明授权Aminotriazolopyridines, compositions thereof, and methods of treatment therewith 有权氨基三唑并吡啶类，其组合物及其处理方法公开(公告)号：US08299056B2
公开(公告)日：2012-10-30
申请号：US12555018
申请日：2009-09-08
申请人： Sogole Bahmanyar , R.J. Bates , Kate Blease , Andrew Calabrese , Thomas Daniel , Mercedes Delgado , Jan Elsner , Paul Erdman , Bruce Fahr , Gregory Ferguson , Branden Lee , Lisa Nadolny , Garrick Packard , Patrick Papa , Veronique Plantevin-Krenitsky , Jennifer Riggs , Patricia Rohane , Sabita Sankar , John Sapienza , Yoshitaka Satoh , Victor Sloan , Randall Stevens , Lida Tehrani , Jayashree Tikhe , Eduardo Torres , Andrew Wallace , Brandon Wade Whitefield , Jingjing Zhao
发明人： Sogole Bahmanyar , R.J. Bates , Kate Blease , Andrew Calabrese , Thomas Daniel , Mercedes Delgado , Jan Elsner , Paul Erdman , Bruce Fahr , Gregory Ferguson , Branden Lee , Lisa Nadolny , Garrick Packard , Patrick Papa , Veronique Plantevin-Krenitsky , Jennifer Riggs , Patricia Rohane , Sabita Sankar , John Sapienza , Yoshitaka Satoh , Victor Sloan , Randall Stevens , Lida Tehrani , Jayashree Tikhe , Eduardo Torres , Andrew Wallace , Brandon Wade Whitefield , Jingjing Zhao
IPC分类号： A61K31/437 , A61K31/5377 , A61K31/497 , A61K31/55 , C07D471/02
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.
摘要翻译： 本文提供了式（I）的杂芳基化合物：其中R 1和R 2如本文所定义，包含有效量的杂芳基化合物的组合物和用于治疗或预防炎性病症或癌症的方法，以及可通过抑制激酶治疗或预防的病症 或激酶途径，其包括向有需要的受试者施用有效量的杂芳基化合物。
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4.发明授权Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US07723340B2
公开(公告)日：2010-05-25
申请号：US11332617
申请日：2006-01-12
申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole
发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole
IPC分类号： C07D473/32 , A61K31/52 , A61F2/82 , A61P3/10 , A61P11/00 , C07D239/50 , C07D239/48
CPC分类号： C07D473/00 , A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症 ，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括施用有效量的 氨基嘌呤化合物对需要的患者。
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5.发明授权Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US08101588B2
公开(公告)日：2012-01-24
申请号：US12404413
申请日：2009-03-16
申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
IPC分类号： C07D473/32 , C07F5/02 , A61K31/52 , A61K31/69 , A61P3/10 , A61P11/00 , C07D239/50 , C07D239/48
CPC分类号： A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。
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6.发明申请公开(公告)号：US20090312320A1
公开(公告)日：2009-12-17
申请号：US12540013
申请日：2009-08-12
申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S.S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole
发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S.S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole
CPC分类号： C07D473/00 , A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症 ，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括施用有效量的 氨基嘌呤化合物对需要的患者。
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7.发明申请HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权羟基取代的氨基酸，其组合物及其处理方法公开(公告)号：US20090275564A1
公开(公告)日：2009-11-05
申请号：US12404413
申请日：2009-03-16
申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S.S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S.S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
IPC分类号： A61K31/52 , C07D473/16 , C07D413/14 , C07D243/08 , A61K31/5377 , A61K31/551 , A61P37/00 , A61P35/00 , A61P9/00
CPC分类号： A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。
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8.发明授权Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US07521446B2
公开(公告)日：2009-04-21
申请号：US11411413
申请日：2006-04-26
申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
IPC分类号： C07D473/32 , A61K31/52 , A61P3/10 , A61P11/00 , C07D239/50 , C07D239/48
CPC分类号： A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。
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9.发明申请Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US20070060598A1
公开(公告)日：2007-03-15
申请号：US11411413
申请日：2006-04-26
申请人： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright
发明人： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright
IPC分类号： A61K31/52 , C07D473/14
CPC分类号： A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，包含有效量的组合物 的氨基嘌呤化合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关的方法 条件，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。
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10.发明申请Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US20060287344A1
公开(公告)日：2006-12-21
申请号：US11332617
申请日：2006-01-12
申请人： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright
发明人： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright
IPC分类号： A61K31/52 , C07D473/14
CPC分类号： C07D473/00 , A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，组合物包含有效的 氨基嘌呤化合物的量和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉 - 相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。
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