摘要:
Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.
摘要:
Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.
摘要:
Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.
摘要:
Provided herein are Pyrazole Pyrazine Amine Compounds having the following structure: Wherein Q and R1-R3 are as defined herein, compositions comprising an effective amount of a Pyrazole Pyrazine Amine Compound and methods for treating or preventing inflammatory conditions, immunological conditions, cancer, neurodegenerative diseases, age-related diseases, cardiovascular diseases and metabolic conditions, or conditions treatable or preventable by inhibition of an IKK, or an IKK pathway, comprising administering an effective amount of a Pyrazole Pyrazine Amine Compound to a patient in need thereof.
摘要:
A planar flexure member for resisting rotation about a central axis thereof includes, in various embodiments, a central portion comprising a plurality of attachment points; and at least one serpentine flexure arm extending from the central portion in a plane. The arm(s) terminate in an arcuate mounting rail that includes a series of attachment points. The rails are positioned in opposition to each other to partially define and occupy a planar circular envelope radially displaced from but surrounding the central portion of the flexure member. A portion of the serpentine arms may extend to (or substantially to) the envelope between the mounting rails.
摘要:
Robots capable of accommodating dynamic replacement of end effectors load and run software that allows the end effector to be operated without change to the main control program. The driver may be dynamically linked and run during program execution when the corresponding end effector is detected. Typically, the robot controller will store a library of drivers, and load the appropriate driver when a new end effector is detected.
摘要:
Apparatuses and methods of manufacturing woven electrical connectors is disclosed. In one embodiment, the connector is formed with a continuous wire having adjacent sections with passageways formed from the wire through which loading elements may be inserted. In some embodiments, the loading elements include spring band clips and/or helical spring coils.
摘要:
A multi-contact electrical connector wafer includes an insulating base and at least one bay on a first side of the base. A conductor is associated with the at least one bay and the conductor is adapted to contact a corresponding mating element. The wafer further includes a loading beam adapted to bias the first conductor toward the corresponding mating element upon deflection of the beam. A connector may be formed with a conductive component disposed in a connector housing defining a receptacle opening. The conductive component is arranged in the housing in a manner to allow the conductive component to move relative to the housing. As such, the connector can accommodate a mating connector of a first thickness or a mating connector of a second, different thickness. The connector may also be adapted to accommodate a mating connector that is inserted into the receptacle in a manner that is not collinear with respect to the receptacle.
摘要:
A method that determines if a sender's message is to be sent to a recipient is presented. A challenge module analyzes the message and sends a challenge message to the sender if the sender is not in the recipient's address store. The challenge message includes a pseudo unique token for the sender recipient pair such that the sender must respond differently to each challenge message for a particular message. In one embodiment, the challenge message requires the sender to obtain a certificate from a certificate authority or a set of authorities.
摘要:
A communications network (e.g. fibre to the home (FTTH) or wireless) comprises a head end, to which outstations are coupled via a shared point-to-multipoint medium. The head end is arranged to transmit downstream to the outstations a sequence of frames comprising data frames and command frames. The command frames marshal control of upstream transmissions from the outstations. A first downstream command frame directed to a specific outstation indicates the beginning of a timeslot, and also indicates the timeslot duration (including an indefinite duration). Where the duration is indefinite, a second command frame directed to at least the same outstation indicates the end of the allotted time slot. Further methods are provided to optimise timeslot allocation, and to support addition and removal of outstations on the network.