专利检索 ap:("Ronald J. Albers" OR "Leticia Ayala" OR "Steven S. Clareen" OR "Maria Mercedes Delgado Mederos" OR "Robert Hilgraf" OR "Sayee G. Hegde" OR "Kevin Hughes" OR "Adam Kois" OR "Veronique Plantevin-Krenitsky" OR "Meg McCarrick" OR "Lisa Nadolny" OR "Moorthy S.S. Palanki" OR "Kiran Sahasrabudhe" OR "John Sapienza" OR "Yoshitaka Satoh" OR "Marianne K. Sloss" OR "Elise Sudbeck" OR "Jonathan Wright") AND inv:"John Sapienza" 第 1 页

1.

发明申请
METHODS OF TREATMENT COMPRISING THE ADMINISTRATION OF HALOARYL SUBSTITUTED AMINOPURINES OR COMPOSITIONS THEREOF 审中-公开
标题翻译：治疗包含取代的氨基酸或其组合物的治疗方法

公开(公告)号：US20090312320A1

公开(公告)日：2009-12-17

申请号：US12540013

申请日：2009-08-12

申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S.S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole

发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S.S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole

IPC分类号： A61K31/52 , A61K31/5377 , A61P29/00 , A61P35/00 , A61P9/00 , A61P25/00

CPC分类号： C07D473/00 , A61K31/52 , C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括施用有效量的氨基嘌呤化合物对需要的患者。

2.

发明申请
HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权
标题翻译：羟基取代的氨基酸，其组合物及其处理方法

公开(公告)号：US20090275564A1

公开(公告)日：2009-11-05

申请号：US12404413

申请日：2009-03-16

申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S.S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright

发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S.S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright

IPC分类号： A61K31/52 , C07D473/16 , C07D413/14 , C07D243/08 , A61K31/5377 , A61K31/551 , A61P37/00 , A61P35/00 , A61P9/00

CPC分类号： A61K31/52 , C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤与需要的患者复合。

3.

发明授权
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权
标题翻译：卤代芳基取代的氨基嘌呤，其组合物及其处理方法

公开(公告)号：US07723340B2

公开(公告)日：2010-05-25

申请号：US11332617

申请日：2006-01-12

申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole

发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright , Ian Henderson , Andrew G. Cole

IPC分类号： C07D473/32 , A61K31/52 , A61F2/82 , A61P3/10 , A61P11/00 , C07D239/50 , C07D239/48

CPC分类号： C07D473/00 , A61K31/52 , C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括施用有效量的氨基嘌呤化合物对需要的患者。

4.

发明授权
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权
标题翻译：卤代芳基取代的氨基嘌呤，其组合物及其处理方法

公开(公告)号：US08101588B2

公开(公告)日：2012-01-24

申请号：US12404413

申请日：2009-03-16

申请人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright

发明人： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Sayee G. Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright

IPC分类号： C07D473/32 , C07F5/02 , A61K31/52 , A61K31/69 , A61P3/10 , A61P11/00 , C07D239/50 , C07D239/48

CPC分类号： A61K31/52 , C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤与需要的患者复合。

5.

发明申请
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权
标题翻译：卤代芳基取代的氨基嘌呤，其组合物及其处理方法

公开(公告)号：US20070060598A1

公开(公告)日：2007-03-15

申请号：US11411413

申请日：2006-04-26

申请人： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright

发明人： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright

IPC分类号： A61K31/52 , C07D473/14

CPC分类号： A61K31/52 , C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，包含有效量的组合物的氨基嘌呤化合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关的方法条件，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。

6.

发明申请
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权
标题翻译：卤代芳基取代的氨基嘌呤，其组合物及其处理方法

公开(公告)号：US20060287344A1

公开(公告)日：2006-12-21

申请号：US11332617

申请日：2006-01-12

申请人： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright

发明人： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright

IPC分类号： A61K31/52 , C07D473/14

CPC分类号： C07D473/00 , A61K31/52 , C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，组合物包含有效的氨基嘌呤化合物的量和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉 - 相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。