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    UNIT DOSE CAPSULES AND DRY POWDER INHALER
    1.
    发明申请
    UNIT DOSE CAPSULES AND DRY POWDER INHALER 有权
    单位剂量胶囊和干粉吸入器

    公开(公告)号：US20080053437A1

    公开(公告)日：2008-03-06

    申请号：US11934643

    申请日：2007-11-02

    申请人： Solomon Steiner ,  Robert Feldstein ,  Per Fog ,  Trent Poole

    发明人： Solomon Steiner ,  Robert Feldstein ,  Per Fog ,  Trent Poole

    IPC分类号： A61M15/00

    CPC分类号： A61M15/003 ,  A61M13/00 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/0023 ,  A61M15/0025 ,  A61M15/0028 ,  A61M15/0043 ,  A61M16/0495 ,  A61M16/0825 ,  A61M2202/064 ,  A61M2205/43 ,  F16L37/252

    摘要： Described is a dry powder inhaler comprising an intake section; a mixing section, and a mouthpiece. The mouthpiece is connected by a swivel joint to the mixing section, and may swivel back onto the intake section and be enclosed by a cover. The intake chamber comprises a special piston with a tapered piston rod and spring, and one or more bleed-through orifices to modulate the flow of air through the device. The intake chamber further optionally comprises a feedback module to generate a tone indicating to the user when the proper rate of airflow has been achieved. The mixing section holds a capsule with holes containing a dry powder medicament, and the cover only can open when the mouthpiece is at a certain angle to the intake section. The mixing section further opens and closes the capsule when the intake section is at a certain angle to the mouthpiece. The mixing section is a Venturi chamber configured by protrusions or spirals to impart a cyclonic flow to air passing through the mixing chamber. The mouthpiece includes a tongue depressor, and a protrusion to contact the lips of the user to tell the user that the DPI is in the correct position. An optional storage section, with a cover, holds additional capsules. The cover for the mouthpiece, and the cover for the storage section may both be transparent, magnifying lenses. The capsules may be two-part capsules where each portion has apertures which correspond to apertures in the other half when each half is partially fitted to the other half, and fully fitted to the other half. All the apertures may be closed when the two halves are rotated around their longitudinal axes with respect to each other. Each capsule may have a unique key on each half that only fits with a particular inhaler.

    摘要翻译： 描述了一种干粉吸入器，其包括进气段; 混合部分和喉舌。 接口通过旋转接头连接到混合部分，并且可以旋转回到进气部分并被盖封闭。 进气室包括具有锥形活塞杆和弹簧的特殊活塞，以及一个或多个渗流孔口，用于调节通过该装置的空气流。 进气室还可选地包括反馈模块，以产生当达到适当的气流速率时向用户指示的音调。 混合部分容纳具有含有干粉药物的孔的胶囊，并且仅当吸嘴与进气部分成一定角度时，盖子才能打开。 当进气部分与嘴件成一定角度时，混合部分进一步打开和关闭胶囊。 混合部分是由突起或螺旋构成的文丘里室，以使气流通过混合室。 接口管包括舌形按压器和用于接触用户嘴唇的突起，以告诉用户DPI处于正确的位置。 带有盖子的可选存储部分可容纳另外的胶囊。 用于接口管的盖和用于存储部的盖可以都是透明的放大镜。 胶囊可以是两部分胶囊，其中每个部分具有对应于另一半中的孔的孔，当每个半部分部分地配合到另一半时，并且完全配合到另一半。 当两个半部相对于彼此的纵向轴线旋转时，所有的孔可以被关闭。 每个胶囊可以在每一半上具有仅与特定吸入器配合的唯一键。

    Unit Dose Capsules and Dry Powder Inhaler
    3.
    发明申请
    Unit Dose Capsules and Dry Powder Inhaler 有权
    单位剂量胶囊和干粉吸入器

    公开(公告)号：US20080127970A1

    公开(公告)日：2008-06-05

    申请号：US11949707

    申请日：2007-12-03

    申请人： Solomon S. Steiner ,  Robert Feldstein ,  Per B. Fog ,  Trent Poole

    发明人： Solomon S. Steiner ,  Robert Feldstein ,  Per B. Fog ,  Trent Poole

    IPC分类号： A61M15/00

    CPC分类号： A61M15/003 ,  A61M13/00 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/0023 ,  A61M15/0025 ,  A61M15/0028 ,  A61M15/0043 ,  A61M16/0495 ,  A61M16/0825 ,  A61M2202/064 ,  A61M2205/43 ,  F16L37/252

    摘要： Described is a dry powder inhaler comprising an intake section; a mixing section, and a mouthpiece. The mouthpiece is connected by a swivel joint to the mixing section, and may swivel back onto the intake section and be enclosed by a cover. The intake chamber comprises a special piston with a tapered piston rod and spring, and one or more bleed-through orifices to modulate the flow of air through the device. The intake chamber further optionally comprises a feedback module to generate a tone indicating to the user when the proper rate of airflow has been achieved. The mixing section holds a capsule with holes containing a dry powder medicament, and the cover only can open when the mouthpiece is at a certain angle to the intake section. The mixing section further opens and closes the capsule when the intake section is at a certain angle to the mouthpiece. The mixing section is a Venturi chamber configured by protrusions or spirals to impart a cyclonic flow to air passing through the mixing chamber. The mouthpiece includes a tongue depressor, and a protrusion to contact the lips of the user to tell the user that the DPI is in the correct position. An optional storage section, with a cover, holds additional capsules. The cover for the mouthpiece, and the cover for the storage section may both be transparent, magnifying lenses. The capsules may be two-part capsules where each portion has apertures which correspond to apertures in the other half when each half is partially fitted to the other half, and fully fitted to the other half. All the apertures may be closed when the two halves are rotated around their longitudinal axes with respect to each other. Each capsule may have a unique key on each half that only fits with a particular inhaler.

    摘要翻译： 描述了一种干粉吸入器，其包括进气段; 混合部分和喉舌。 接口通过旋转接头连接到混合部分，并且可以旋转回到进气部分并被盖封闭。 进气室包括具有锥形活塞杆和弹簧的特殊活塞，以及一个或多个渗流孔口，用于调节通过该装置的空气流。 进气室还可选地包括反馈模块，以产生当达到适当的气流速率时向用户指示的音调。 混合部分容纳具有含有干粉药物的孔的胶囊，并且仅当吸嘴与进气部分成一定角度时，盖子才能打开。 当进气部分与嘴件成一定角度时，混合部分进一步打开和关闭胶囊。 混合部分是由突起或螺旋构成的文丘里室，以使气流通过混合室。 接口管包括舌形按压器和用于接触用户嘴唇的突起，以告诉用户DPI处于正确的位置。 带有盖子的可选存储部分可容纳另外的胶囊。 用于接口管的盖和用于存储部的盖可以都是透明的放大镜。 胶囊可以是两部分胶囊，其中每个部分具有对应于另一半中的孔的孔，当每个半部分部分地配合到另一半时，并且完全配合到另一半。 当两个半部相对于彼此的纵向轴线旋转时，所有的孔可以被关闭。 每个胶囊可以在每一半上具有仅与特定吸入器配合的唯一键。

    Unit dose capsules for use in a dry powder inhaler
    4.
    发明授权
    Unit dose capsules for use in a dry powder inhaler 有权
    用于干粉吸入器的单位剂量胶囊

    公开(公告)号：US07305986B1

    公开(公告)日：2007-12-11

    申请号：US09621092

    申请日：2000-07-21

    申请人： Solomon S. Steiner ,  Robert Feldstein ,  Per B. Fog ,  Trent Poole

    发明人： Solomon S. Steiner ,  Robert Feldstein ,  Per B. Fog ,  Trent Poole

    IPC分类号： A61M15/00

    CPC分类号： A61M15/003 ,  A61M13/00 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/0023 ,  A61M15/0025 ,  A61M15/0028 ,  A61M15/0043 ,  A61M16/0495 ,  A61M16/0825 ,  A61M2202/064 ,  A61M2205/43 ,  F16L37/252

    摘要： Described are capsules to contain a drug for use in an inhaler. The capsules may be two-part capsules where each half has apertures which may correspond to apertures in the other half. The first half fits snugly within the second half and the two halves may be rotated around their longitudinal axes with respect to each other to produce unlocked and locked positions. In the unlocked position, at least one aperture in the first half aligns with at least one aperture in the second half, which permits introduction of a medicament. In the locked position, at least two apertures in the first half align with at least two apertures in the second half, allowing air to pass through the capsule, releasing the medicament contained therein. Each capsule may have a unique key on each half that only fits with a particular inhaler or identifies the medicament contained therein.

    摘要翻译： 描述了容纳用于吸入器的药物的胶囊。 胶囊可以是两部分胶囊，其中每一半具有可对应于另一半中的孔的孔。 前半部分紧密地配合在第二半部分内，并且两个半部可以相对于彼此绕其纵向轴线旋转以产生解锁和锁定位置。 在解锁位置，前半部中的至少一个孔与第二半中的至少一个孔对准，这允许引入药物。 在锁定位置，第一半部中的至少两个孔与第二半部中的至少两个孔对准，允许空气通过胶囊，释放其中所含的药物。 每个胶囊可以在每一半上具有仅与特定吸入器匹配的识别钥匙，或识别其中包含的药物。

    Method and Device for Sublingual Drug Delivery Using Iontophoresis
    8.
    发明申请
    Method and Device for Sublingual Drug Delivery Using Iontophoresis 审中-公开
    使用离子电渗法进行舌下给药的方法和装置

    公开(公告)号：US20070191757A1

    公开(公告)日：2007-08-16

    申请号：US11675430

    申请日：2007-02-15

    申请人： Solomon Steiner ,  Robert Feldstein ,  Roderike Pohl ,  David Rhodes ,  Erik Steiner

    发明人： Solomon Steiner ,  Robert Feldstein ,  Roderike Pohl ,  David Rhodes ,  Erik Steiner

    IPC分类号： A61N1/30

    CPC分类号： A61N1/306 ,  A61M2210/0625 ,  A61M2210/0643

    摘要： Methods, devices and kits for sublingual drug delivery using iontophoresis are described herein. An active agent can be administered sublingually by placing a solid oral dosage form containing the active agent in the sublingual region of a patient and applying iontophoresis for a suitable period of time. Preferably up to 4 mA of current are applied to the sublingual region. Different time ranges can be used to administer iontophoresis; preferably iontophoresis is administered for up to 2 minutes at a time. Any suitable device for administering iontophoresis to the sublingual region may be used. The preferred device is a hand-held device that contains a handle, two electrodes, one of which is located on the handle and the other of which is attached to the end of the handle, and a connection to a power source. Optionally, the device contains a timer, which can be used turn off the current at a preset time. The device can be used to administer an active agent by iontophoresis to the sublingual region of a patient, by attaching the second electrode of the device to a solid oral dosage form containing the active agent to be administered. A kit contains the device for administering iontophoresis and one or more solid oral dosage forms, preferably in the form of one or more tabs or wafers. The tabs or wafers may be completely dissolvable or edible, or may contain a non-edible and non-dissolvable component. In a preferred embodiment, the solid oral dosage form contains insulin or an analog thereof and one or more excipients, preferably EDTA and citric acid.

    摘要翻译： 本文描述了使用离子电渗法进行舌下药物递送的方法，装置和试剂盒。 可以通过将含有活性剂的固体口服剂型置于患者的舌下区域中并施用离子电渗疗法适当的时间段来向舌下施用活性剂。 优选地，最多将4mA的电流施加到舌下区域。 不同的时间范围可用于管理离子电渗疗法; 优选每次一次给予离子电渗疗法达2分钟。 可以使用用于向舌下区域施用离子电渗疗法的任何合适的装置。 优选的装置是手持装置，其包括手柄，两个电极，其中一个电极位于手柄上，另一个电极连接到手柄的端部，并且连接到电源。 可选地，设备包含定时器，其可以在预设时间关闭电流。 该装置可用于通过将装置的第二电极连接到含有待施用的活性剂的固体口服剂型，通过离子电渗法向患者的舌下区域施用活性剂。 试剂盒包含用于施用离子电渗疗法的装置和一种或多种固体口服剂型，优选以一个或多个片或晶片的形式。 标签或晶片可以是完全可溶的或可食用的，或者可以包含不可食用和不可溶的组分。 在优选的实施方案中，固体口服剂型含有胰岛素或其类似物和一种或多种赋形剂，优选EDTA和柠檬酸。

    Methods for fine powder formation
    9.
    发明申请
    Methods for fine powder formation 有权

    公开(公告)号：US20060191375A1

    公开(公告)日：2006-08-31

    申请号：US11385513

    申请日：2006-03-21

    申请人： Robert Feldstein ,  Solomon Steiner

    发明人： Robert Feldstein ,  Solomon Steiner

    IPC分类号： B22F9/08

    CPC分类号： A61K9/0073 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1688 ,  A61K9/1694 ,  F26B5/065

    摘要： Improved methods for forming fine particles of a material have been developed, wherein the method steps include dissolving the material in a solvent to form a dilute solution, immobilizing the dilution solution, and then removing the solvent to yield particles of the material. Methods of immobilizing the dilute solution include freezing, gelation, and chelation. In a preferred embodiment, the immobilized solvent is removed by lyophilization, i.e. reducing the ambient pressure while avoiding application of sufficient heat to power a phase transition. Essentially any material and solvent for the material can be used in the methods described herein. Proteins and peptides in an aqueous solvent are the preferred systems.