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    Method and Device for Sublingual Drug Delivery Using Iontophoresis
    6.
    发明申请
    Method and Device for Sublingual Drug Delivery Using Iontophoresis 审中-公开
    使用离子电渗法进行舌下给药的方法和装置

    公开(公告)号：US20070191757A1

    公开(公告)日：2007-08-16

    申请号：US11675430

    申请日：2007-02-15

    申请人： Solomon Steiner ,  Robert Feldstein ,  Roderike Pohl ,  David Rhodes ,  Erik Steiner

    发明人： Solomon Steiner ,  Robert Feldstein ,  Roderike Pohl ,  David Rhodes ,  Erik Steiner

    IPC分类号： A61N1/30

    CPC分类号： A61N1/306 ,  A61M2210/0625 ,  A61M2210/0643

    摘要： Methods, devices and kits for sublingual drug delivery using iontophoresis are described herein. An active agent can be administered sublingually by placing a solid oral dosage form containing the active agent in the sublingual region of a patient and applying iontophoresis for a suitable period of time. Preferably up to 4 mA of current are applied to the sublingual region. Different time ranges can be used to administer iontophoresis; preferably iontophoresis is administered for up to 2 minutes at a time. Any suitable device for administering iontophoresis to the sublingual region may be used. The preferred device is a hand-held device that contains a handle, two electrodes, one of which is located on the handle and the other of which is attached to the end of the handle, and a connection to a power source. Optionally, the device contains a timer, which can be used turn off the current at a preset time. The device can be used to administer an active agent by iontophoresis to the sublingual region of a patient, by attaching the second electrode of the device to a solid oral dosage form containing the active agent to be administered. A kit contains the device for administering iontophoresis and one or more solid oral dosage forms, preferably in the form of one or more tabs or wafers. The tabs or wafers may be completely dissolvable or edible, or may contain a non-edible and non-dissolvable component. In a preferred embodiment, the solid oral dosage form contains insulin or an analog thereof and one or more excipients, preferably EDTA and citric acid.

    摘要翻译： 本文描述了使用离子电渗法进行舌下药物递送的方法，装置和试剂盒。 可以通过将含有活性剂的固体口服剂型置于患者的舌下区域中并施用离子电渗疗法适当的时间段来向舌下施用活性剂。 优选地，最多将4mA的电流施加到舌下区域。 不同的时间范围可用于管理离子电渗疗法; 优选每次一次给予离子电渗疗法达2分钟。 可以使用用于向舌下区域施用离子电渗疗法的任何合适的装置。 优选的装置是手持装置，其包括手柄，两个电极，其中一个电极位于手柄上，另一个电极连接到手柄的端部，并且连接到电源。 可选地，设备包含定时器，其可以在预设时间关闭电流。 该装置可用于通过将装置的第二电极连接到含有待施用的活性剂的固体口服剂型，通过离子电渗法向患者的舌下区域施用活性剂。 试剂盒包含用于施用离子电渗疗法的装置和一种或多种固体口服剂型，优选以一个或多个片或晶片的形式。 标签或晶片可以是完全可溶的或可食用的，或者可以包含不可食用和不可溶的组分。 在优选的实施方案中，固体口服剂型含有胰岛素或其类似物和一种或多种赋形剂，优选EDTA和柠檬酸。

    Methods for fine powder formation
    7.
    发明申请
    Methods for fine powder formation 有权

    公开(公告)号：US20060191375A1

    公开(公告)日：2006-08-31

    申请号：US11385513

    申请日：2006-03-21

    申请人： Robert Feldstein ,  Solomon Steiner

    发明人： Robert Feldstein ,  Solomon Steiner

    IPC分类号： B22F9/08

    CPC分类号： A61K9/0073 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1688 ,  A61K9/1694 ,  F26B5/065

    摘要： Improved methods for forming fine particles of a material have been developed, wherein the method steps include dissolving the material in a solvent to form a dilute solution, immobilizing the dilution solution, and then removing the solvent to yield particles of the material. Methods of immobilizing the dilute solution include freezing, gelation, and chelation. In a preferred embodiment, the immobilized solvent is removed by lyophilization, i.e. reducing the ambient pressure while avoiding application of sufficient heat to power a phase transition. Essentially any material and solvent for the material can be used in the methods described herein. Proteins and peptides in an aqueous solvent are the preferred systems.

    System for controlling access to computer bus having address phase and data phase by prolonging the generation of request signal
    8.
    发明授权
    System for controlling access to computer bus having address phase and data phase by prolonging the generation of request signal 失效
    用于通过延长请求信号的产生来控制具有地址相位和数据相位的计算机总线的访问系统

    公开(公告)号：US4908749A

    公开(公告)日：1990-03-13

    申请号：US798595

    申请日：1985-11-15

    申请人： Peter G. Marshall ,  Robert Feldstein

    发明人： Peter G. Marshall ,  Robert Feldstein

    IPC分类号： G06F13/20 ,  G06F11/10 ,  G06F13/36 ,  G06F13/378 ,  G06F13/42

    CPC分类号： G06F13/378 ,  G06F13/4243 ,  G06F11/10

    摘要： A computing system is disclosed which uses a system busy signal on its system bus to help control access to said bus. One or more requesters can generate a request signal when the system busy signal is not asserted. System busy is asserted along with the request signal(s) and remains asserted until all requesters which generated a request signal have gained access to the bus in order of priority. A freeze signal is generated on the system bus during the address phase of an instruction and a wait signal is generated during each data transfer in the data phase of an instruction. The freeze signal may be generated by a memory control unit, a memory module or a requester.

    摘要翻译： 公开了一种计算系统，其在其系统总线上使用系统忙信号来帮助控制对所述总线的访问。 一个或多个请求者可以在系统忙信号未被置位时产生请求信号。 系统忙与请求信号一起被断言，并保持断言，直到生成请求信号的所有请求者已经按照优先级顺序访问总线。 在指令的地址相位期间，在系统总线上产生冻结信号，并且在指令的数据阶段中的每个数据传输期间产生等待信号。 冻结信号可以由存储器控制单元，存储器模块或请求器产生。