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公开(公告)号：US08961589B2
公开(公告)日：2015-02-24
申请号：US11888807
申请日：2007-08-01
申请人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
发明人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
CPC分类号： A61L31/16 , A61K31/436 , A61K47/34 , A61L31/10 , A61L31/148 , A61L2300/416 , C08L67/04
摘要： The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.
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2.发明申请公开(公告)号：US20090240325A1
公开(公告)日：2009-09-24
申请号：US12052452
申请日：2008-03-20
申请人： Shaw Ling Hsu , Yiwen Tang , Lothar W. Kleiner , Fuh-Wei Tang , Ni Ding , Syed Faiyaz Ahmed Hossainy
发明人： Shaw Ling Hsu , Yiwen Tang , Lothar W. Kleiner , Fuh-Wei Tang , Ni Ding , Syed Faiyaz Ahmed Hossainy
CPC分类号： A61L27/34 , A61L31/10 , A61L2420/08 , C08L67/04
摘要： Implantable medical device coatings that have improved mechanical stability and medical devices coated with such coatings are disclosed.
摘要翻译： 公开了具有改善的机械稳定性的植入式医疗装置涂层和涂覆有这种涂层的医疗装置。
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3.发明授权Medical device coated with a coating containing elastin pentapeptide VGVPG 有权涂有含有弹性蛋白五肽VGVPG的涂层的医疗器械公开(公告)号：US08029816B2
公开(公告)日：2011-10-04
申请号：US11803031
申请日：2007-05-10
CPC分类号： A61L31/10 , A61K38/08 , A61K38/39 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2420/02 , B05D3/007 , C07K14/001 , C08H1/00 , Y10T428/3154 , Y10T428/31909
摘要： The present invention is directed to medical devices including coatings. The coatings include a topcoat which includes a copolymer comprising a block of an elastin pentapeptide. The topcoat is over a layer of poly(vinyl alcohol) on a hydrophobic coating or over a porous coating comprising pores or depots that include a bioactive agent.
摘要翻译： 本发明涉及包括涂层在内的医疗装置。 涂层包括面漆，其包括包含弹性蛋白五肽嵌段的共聚物。 面漆在疏水涂层上方的多层（聚乙烯醇）层上或包含孔或包含生物活性剂的贮槽的多孔涂层上方。
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4.发明授权公开(公告)号：US08377116B2
公开(公告)日：2013-02-19
申请号：US12052452
申请日：2008-03-20
申请人： Shaw Ling Hsu , Yiwen Tang , Lothar W. Kleiner , Fuh-Wei Tang , Ni Ding , Syed Faiyaz Ahmed Hossainy
发明人： Shaw Ling Hsu , Yiwen Tang , Lothar W. Kleiner , Fuh-Wei Tang , Ni Ding , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61F2/06
CPC分类号： A61L27/34 , A61L31/10 , A61L2420/08 , C08L67/04
摘要： The present invention provides an implantable medical device coating that has improved stability, a medical device coated with such coating, and a method of increasing the stability of an implantable medical device coating, wherein the coating comprises a stereocomplex f poly(D-lactic acid) and poly(L-lactice acid).
摘要翻译： 本发明提供了具有改善的稳定性的可植入医疗装置涂层，涂覆有这种涂层的医疗装置以及增加可植入医疗装置涂层的稳定性的方法，其中所述涂层包含立体络合物f聚（D-乳酸） 和聚（L-乳酸））。
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公开(公告)号：US20090036978A1
公开(公告)日：2009-02-05
申请号：US11888807
申请日：2007-08-01
申请人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
发明人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61K31/436 , A61K47/34 , A61L31/10 , A61L31/148 , A61L2300/416 , C08L67/04
摘要： The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.
摘要翻译： 本发明涉及涂覆有具有可调谐疏水性的聚合物的可植入医疗装置及其在治疗血管疾病中的用途。
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6.发明授权公开(公告)号：US08551512B2
公开(公告)日：2013-10-08
申请号：US10807546
申请日：2004-03-22
IPC分类号： A61F2/82
CPC分类号： B05D5/00 , A61F2/82 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/63 , A61L2420/02 , A61L2420/08 , C08L67/02
摘要： Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.
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7.发明授权公开(公告)号：US08017140B2
公开(公告)日：2011-09-13
申请号：US11804997
申请日：2007-05-21
申请人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译： 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。
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8.发明授权Methods for modulating thermal and mechanical properties of coatings on implantable devices 有权调制可植入设备上涂层的热和机械性能的方法公开(公告)号：US07820732B2
公开(公告)日：2010-10-26
申请号：US10835656
申请日：2004-04-30
申请人： Syed Faiyaz Ahmed Hossainy , Yiwen Tang , Harshad Borgaonkor , Jessica Reneé DesNoyer , Stephen D. Pacetti
发明人： Syed Faiyaz Ahmed Hossainy , Yiwen Tang , Harshad Borgaonkor , Jessica Reneé DesNoyer , Stephen D. Pacetti
摘要： Methods for modulating and enhancing thermal and mechanical properties and biocompatibilities of coatings on implantable devices are disclosed. Implantable devices containing the enhanced thermal and mechanical properties and biocompatibilities are also described. The implantable devices can be used to treat a medical condition such as vulnerable plaque or restenosis.
摘要翻译： 公开了用于调节和增强可植入装置上的涂层的热机械性能和生物相容性的方法。 还描述了包含增强的热和机械性能和生物相容性的可植入装置。 可植入装置可用于治疗诸如易损斑块或再狭窄的医疗状况。
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公开(公告)号：US09814553B1
公开(公告)日：2017-11-14
申请号：US11870394
申请日：2007-10-10
申请人： Lothar Walter Kleiner , Yiwen Tang , Syed Faiyaz Ahmed Hossainy , Florencia Lim , Michael Ngo , Mikael Trollsas , Qing Lin
发明人： Lothar Walter Kleiner , Yiwen Tang , Syed Faiyaz Ahmed Hossainy , Florencia Lim , Michael Ngo , Mikael Trollsas , Qing Lin
IPC分类号： A61F2/00
CPC分类号： A61F2/00 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , C08L67/04
摘要： The present invention provides a semi-crystalline polymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.
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公开(公告)号：US08980300B2
公开(公告)日：2015-03-17
申请号：US12475296
申请日：2009-05-29
IPC分类号： A61F2/00 , A61K39/00 , A61F2/06 , A61F2/02 , A61K38/22 , A61K38/00 , A61K31/44 , A61K31/445 , A61L27/34 , A61L27/50 , A61L31/10 , A61L31/14
CPC分类号： A61K47/34 , A61K31/436 , A61L27/34 , A61L27/502 , A61L31/10 , A61L31/141 , C08K5/1575 , C08L67/04 , C09D167/00
摘要： A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译： 提供了可用于形成具有生物相容性聚合物的涂料组合物的生物相容性增塑剂。 涂料组合物还可以包括生物有益的聚合物和/或生物活性剂。 涂料组合物可以在可植入装置上形成涂层。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞 ，输尿管阻塞，肿瘤阻塞或其组合。
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