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公开(公告)号：US08961589B2
公开(公告)日：2015-02-24
申请号：US11888807
申请日：2007-08-01
申请人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
发明人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
CPC分类号： A61L31/16 , A61K31/436 , A61K47/34 , A61L31/10 , A61L31/148 , A61L2300/416 , C08L67/04
摘要： The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.
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2.发明授权Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same 有权聚（酰胺）和聚（酯 - 酰胺）聚合物和药物递送颗粒和含有它们的涂层公开(公告)号：US08916187B2
公开(公告)日：2014-12-23
申请号：US13221767
申请日：2011-08-30
CPC分类号： C08L77/12 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/62 , C08G69/44 , C08G69/48
摘要： The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
摘要翻译： 本发明涉及聚（酰胺）和聚（酯 - 酰胺）聚合物，包括聚合物的涂层和包括聚合物的窄多分散药物递送颗粒。
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3.发明授权公开(公告)号：US08765162B2
公开(公告)日：2014-07-01
申请号：US12165173
申请日：2008-06-30
IPC分类号： A61F2/02
CPC分类号： C08L77/12 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/62 , C08G69/44 , C08G69/48
摘要： The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
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4.发明授权Poly(ester-amide) and poly(amide) coatings for implantable medical devices for controlled release of a protein or peptide and a hydrophobic drug 有权用于可控制的蛋白质或肽和疏水性药物释放的可植入医疗器械的聚（酯 - 酰胺）和聚（酰胺）涂层公开(公告)号：US08323676B2
公开(公告)日：2012-12-04
申请号：US12165521
申请日：2008-06-30
IPC分类号： A61F2/02 , C07D491/16
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/252 , A61L2300/602 , A61L2300/606 , C08L77/00
摘要： This invention is generally related to coatings for implantable medical devices, such as drug delivery vascular stents. The coating includes a drug reservoir layer above the outer surface of the device body, the drug reservoir layer with a peptide or protein, a hydrophobic drug, and a polymer with a weight average molecular weight between about 10,000 to about 150,000 Daltons. A preferred polymer is a poly(ester amide) polymer.
摘要翻译： 本发明通常涉及用于可植入医疗装置的涂层，例如药物输送血管支架。 涂层包括在装置主体的外表面上方的药物储存层，具有肽或蛋白质的药物储存层，疏水性药物和重均分子量在约10,000至约150,000道尔顿之间的聚合物。 优选的聚合物是聚（酯酰胺）聚合物。
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公开(公告)号：US20080145393A1
公开(公告)日：2008-06-19
申请号：US11638780
申请日：2006-12-13
申请人： Mikael O. Trollsas , Michael Huy Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Lothar W. Kleiner
发明人： Mikael O. Trollsas , Michael Huy Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Lothar W. Kleiner
CPC分类号： A61L31/10 , A61F2/82 , A61L27/34 , A61L27/54 , A61L27/58 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C09D143/02
摘要： A coating of fast absorption or fast dissolution on an implantable device and methods of making and using of the coating are provided.
摘要翻译： 提供了在可植入装置上快速吸收或快速溶解的涂层以及制备和使用涂层的方法。
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公开(公告)号：US08597673B2
公开(公告)日：2013-12-03
申请号：US11638780
申请日：2006-12-13
申请人： Mikael O. Trollsas , Michael Huy Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Lothar W. Kleiner
发明人： Mikael O. Trollsas , Michael Huy Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Lothar W. Kleiner
CPC分类号： A61L31/10 , A61F2/82 , A61L27/34 , A61L27/54 , A61L27/58 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C09D143/02
摘要： A coating of fast absorption or fast dissolution on an implantable device and methods of making and using of the coating are provided.
摘要翻译： 提供了在可植入装置上快速吸收或快速溶解的涂层以及制备和使用涂层的方法。
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公开(公告)号：US20090036978A1
公开(公告)日：2009-02-05
申请号：US11888807
申请日：2007-08-01
申请人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
发明人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61K31/436 , A61K47/34 , A61L31/10 , A61L31/148 , A61L2300/416 , C08L67/04
摘要： The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.
摘要翻译： 本发明涉及涂覆有具有可调谐疏水性的聚合物的可植入医疗装置及其在治疗血管疾病中的用途。
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8.发明申请BIOSOLUBLE COATING COMPRISING ANTI-PROLIFERATIVE AND ANTI-INFLAMMATORY AGENT COMBINATION FOR TREATMENT OF VASCULAR DISORDERS 审中-公开包含抗增生剂和抗炎药物组合的生物可溶性涂层用于治疗血管疾病公开(公告)号：US20090297578A1
公开(公告)日：2009-12-03
申请号：US12132535
申请日：2008-06-03
申请人： MIKAEL O. TROLLSAS , Michael H. Ngo , Florencia Lim , Syed F.A. Hossainy , Bozena Zofia Maslanka
发明人： MIKAEL O. TROLLSAS , Michael H. Ngo , Florencia Lim , Syed F.A. Hossainy , Bozena Zofia Maslanka
IPC分类号： A61F2/00 , A61K31/445 , A61K31/56
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61L2300/604 , A61L2300/606
摘要： Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.
摘要翻译： 提供了药物递送系统，例如具有抗增殖剂如依维莫司的药物递送支架和抗炎剂如氯倍他索。 还公开了治疗血管损伤如再狭窄或易损斑块的方法。
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9.发明申请IMPLANTABLE MEDICAL DEVICE COMPRISING A PRO-HEALING POLY(ESTER-AMIDE) 审中-公开包含助剂（ESTER-AMIDE）的可植入医疗装置公开(公告)号：US20090181063A1
公开(公告)日：2009-07-16
申请号：US12046348
申请日：2008-03-11
IPC分类号： A61F2/00 , A61K31/74 , A61K31/436 , A61K47/32 , A61K47/30
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/608 , A61L2420/08 , C08L77/12
摘要： The present invention relates to implantable medical devices, in particular stents, comprising pro-healing poly(ester-amide)s.
摘要翻译： 本发明涉及可植入医疗装置，特别是支架，其包括预处理聚（酯 - 酰胺）。
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10.发明申请Polymer blends for drug delivery stent matrix with improved thermal stability 审中-公开用于药物递送支架基质的聚合物共混物具有改善的热稳定性公开(公告)号：US20090111787A1
公开(公告)日：2009-04-30
申请号：US11982168
申请日：2007-10-31
CPC分类号： A61L31/10 , A61L2420/02 , A61L2420/06 , C08L67/04 , C09D167/04 , C08L2666/18
摘要： Various embodiments of the present invention generally relate to a polymer blend composition used for coating a medical device that exhibits improved thermal stability. The invention also encompasses implantable medical devices coated the aforementioned coating.
摘要翻译： 本发明的各种实施方案一般涉及用于涂覆显示改善的热稳定性的医疗装置的聚合物共混物组合物。 本发明还包括涂覆上述涂层的可植入医疗装置。
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