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公开(公告)号：US11702419B2
公开(公告)日：2023-07-18
申请号：US17201878
申请日：2021-03-15
发明人： Yuya Oguro , Shigemitsu Matsumoto , Takeshi Wakabayashi , Norihito Tokunaga , Taku Kamei , Mitsuhiro Ito , Satoshi Mikami , Masaki Seto , Shinji Morimoto , Shinji Nakamura , Sachie Takashima , Masataka Murakami , Masaki Daini , Makoto Kamata , Minoru Nakamura , Yasufumi Wada , Hiroyuki Kakei , Kazuaki Takami , Taisuke Tawaraishi , Jumpei Aida , Kouichi Iwanaga , Satoshi Yamamoto
IPC分类号： C07D487/04 , A61K9/20 , A61K9/48 , C07D471/04 , A61P25/00
CPC分类号： C07D487/04 , A61K9/2095 , A61K9/4833 , A61P25/00 , C07D471/04
摘要： The present invention provides a heterocyclic compound having an antagonistic action on an NMDA receptor containing the NR2B subunit, and expected to be useful as an agent for the prophylaxis or treatment of major depression, bipolar disorder, migraine, pain, behavioral and psychological symptoms of dementia and the like.
The present invention relates to a compound represented by the formula (I):
wherein each symbol is as described in the description, or a salt thereof.-
公开(公告)号：US20210277030A1
公开(公告)日：2021-09-09
申请号：US17316185
申请日：2021-05-10
发明人： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC分类号： C07F7/08 , C07D205/04 , C07D207/12 , C07K5/065 , C07D239/36 , C07D213/64 , C07D309/06 , C07D333/38 , C07F7/10 , C07D403/06 , C07D271/10 , C07C237/22 , C07D295/14 , C07D207/26 , C07D413/12 , C07F7/30 , C07D233/72 , C07D309/08 , C07D231/56 , C07D261/08 , C07D209/18 , C07D405/12 , C07D261/12 , C07D239/54 , C07D211/62 , C07D237/14 , C07D231/12 , C07D487/04 , A61P43/00 , A61P29/00 , A61P25/00 , A61P19/02 , A61P17/06 , A61P1/04 , C07K5/087
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US20200010487A1
公开(公告)日：2020-01-09
申请号：US16576293
申请日：2019-09-19
发明人： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC分类号： C07F7/08 , C07D205/04 , C07D207/12 , C07K5/065 , C07K5/087
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US20180319812A1
公开(公告)日：2018-11-08
申请号：US16035277
申请日：2018-07-13
发明人： Satoshi Yamamoto , Junya Shirai , Hiroyuki Watanabe , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Yoshiyuki Fukase , Tomoya Yukawa
IPC分类号： C07D491/056 , C07F7/08 , C07D217/26 , C07D413/12 , C07D401/12 , C07D405/12 , C07D401/04 , C07D413/14 , C07D491/048 , C07D471/04 , C07D417/06 , C07D413/06 , C07D409/06 , C07D405/06 , C07D401/06 , C07D491/04
CPC分类号： C07D491/056 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D491/04 , C07D491/048 , C07F7/0812
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. wherein each symbol is as defined in the specification.
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公开(公告)号：US09365520B2
公开(公告)日：2016-06-14
申请号：US14755439
申请日：2015-06-30
发明人： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC分类号： C07D471/04 , C07D215/00 , C07D491/14 , C07D217/26 , C07F7/08 , C07D491/048 , C07D491/056 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14
CPC分类号： C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
摘要： The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
摘要翻译： 本发明提供具有RORγt抑制作用的杂环化合物。 本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义。 或其盐。
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6.发明授权公开(公告)号：US10093629B2
公开(公告)日：2018-10-09
申请号：US15321609
申请日：2015-06-30
发明人： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC分类号： C07D217/26 , C07D491/056 , C07D491/048 , C07F7/08 , C07D471/04 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D491/14
摘要： Provided are heterocyclic compounds having a RORγt inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US10053468B2
公开(公告)日：2018-08-21
申请号：US14902309
申请日：2014-07-02
发明人： Satoshi Yamamoto , Junya Shirai , Hiroyuki Watanabe , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Yoshiyuki Fukase , Tomoya Yukawa
IPC分类号： C07D491/056 , C07D217/26 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D491/048 , C07D401/12 , C07D413/12 , C07D491/04 , C07D413/14 , C07D401/04 , C07D405/12 , C07F7/08
CPC分类号： C07D491/056 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D491/04 , C07D491/048 , C07F7/0812
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. wherein each symbol is as defined in the specification.
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公开(公告)号：US09650343B2
公开(公告)日：2017-05-16
申请号：US15055156
申请日：2016-02-26
发明人： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC分类号： C07D471/04 , C07D215/00 , C07D217/26 , C07F7/08 , C07D491/048 , C07D491/056 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D491/14
CPC分类号： C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
摘要： The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
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公开(公告)号：US20170107240A1
公开(公告)日：2017-04-20
申请号：US14902388
申请日：2014-07-02
发明人： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC分类号： C07F7/08 , C07D205/04 , C07D207/12 , C07K5/065 , C07K5/087
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US09573903B2
公开(公告)日：2017-02-21
申请号：US15055197
申请日：2016-02-26
发明人： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC分类号： C07D471/04 , C07D215/00 , C07D217/26 , C07F7/08 , C07D491/048 , C07D491/056 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D491/14
CPC分类号： C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
摘要： The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
摘要翻译： 本发明提供具有RORγt抑制作用的杂环化合物。 本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义。 或其盐。
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