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公开(公告)号：USRE49686E1
公开(公告)日：2023-10-10
申请号：US17076227
申请日：2020-10-21
发明人： Junya Shirai , Hideyuki Sugiyama , Taku Kamei , Hironobu Maezaki
IPC分类号： C07D401/04 , C07D207/14 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/08 , C07D413/14 , C07D417/08
CPC分类号： C07D401/04 , C07D207/14 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/08 , C07D413/14 , C07D417/08
摘要： The present invention relates to a compound represented by the formula
wherein ring A is a nitrogen-containing heterocycle;
ring B is an aromatic ring optionally having substituent(s);
ring D is an aromatic ring optionally having substituent(s);
L is a group represented by the formula
R2, R3, R4a ′ and R4b are each independently a hydrogen atom, an optionally halogenated C1-6 alkyl group or an optionally halogenated C3-6 cycloalkyl group, or R2 and R3 are optionally bonded via an alkylene chain or an alkenylene chain, or R4a and R4b are optionally bonded via an alkylene chain or an alkenylene chain;
R1 is a hydrogen atom or a substituent;
m and n are each independently an integer of 0 to 5;
m+n is an integer of 2 to 5; and
is a single bond or double bond, or a salt thereof; and the like. The compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, digestive tract diseases, central neurological disease and the like.-
公开(公告)号：US20210277030A1
公开(公告)日：2021-09-09
申请号：US17316185
申请日：2021-05-10
发明人： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC分类号： C07F7/08 , C07D205/04 , C07D207/12 , C07K5/065 , C07D239/36 , C07D213/64 , C07D309/06 , C07D333/38 , C07F7/10 , C07D403/06 , C07D271/10 , C07C237/22 , C07D295/14 , C07D207/26 , C07D413/12 , C07F7/30 , C07D233/72 , C07D309/08 , C07D231/56 , C07D261/08 , C07D209/18 , C07D405/12 , C07D261/12 , C07D239/54 , C07D211/62 , C07D237/14 , C07D231/12 , C07D487/04 , A61P43/00 , A61P29/00 , A61P25/00 , A61P19/02 , A61P17/06 , A61P1/04 , C07K5/087
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US20200010487A1
公开(公告)日：2020-01-09
申请号：US16576293
申请日：2019-09-19
发明人： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC分类号： C07F7/08 , C07D205/04 , C07D207/12 , C07K5/065 , C07K5/087
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US20180319812A1
公开(公告)日：2018-11-08
申请号：US16035277
申请日：2018-07-13
发明人： Satoshi Yamamoto , Junya Shirai , Hiroyuki Watanabe , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Yoshiyuki Fukase , Tomoya Yukawa
IPC分类号： C07D491/056 , C07F7/08 , C07D217/26 , C07D413/12 , C07D401/12 , C07D405/12 , C07D401/04 , C07D413/14 , C07D491/048 , C07D471/04 , C07D417/06 , C07D413/06 , C07D409/06 , C07D405/06 , C07D401/06 , C07D491/04
CPC分类号： C07D491/056 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D491/04 , C07D491/048 , C07F7/0812
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. wherein each symbol is as defined in the specification.
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公开(公告)号：US09365520B2
公开(公告)日：2016-06-14
申请号：US14755439
申请日：2015-06-30
发明人： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC分类号： C07D471/04 , C07D215/00 , C07D491/14 , C07D217/26 , C07F7/08 , C07D491/048 , C07D491/056 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14
CPC分类号： C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
摘要： The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
摘要翻译： 本发明提供具有RORγt抑制作用的杂环化合物。 本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义。 或其盐。
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公开(公告)号：US10472376B2
公开(公告)日：2019-11-12
申请号：US14902388
申请日：2014-07-02
发明人： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC分类号： C07F7/08 , C07D309/06 , C07D405/12 , C07D239/36 , C07D413/12 , C07D205/04 , C07C237/22 , C07D207/12 , C07D271/10 , C07F7/10 , C07F7/30 , C07K5/065 , C07D309/08 , C07D231/12 , C07D231/56 , C07D333/38 , C07D233/72 , C07D403/06 , C07D237/14 , C07D239/54 , C07K5/087
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US10000488B2
公开(公告)日：2018-06-19
申请号：US15510225
申请日：2015-09-10
发明人： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Takashi Imada , Mitsunori Kono , Ayumu Sato , Yoshihide Tomata , Atsuko Ochida , Naoki Ishii , Yusuke Sasaki , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC分类号： C07D471/04 , C07D401/14 , C07D413/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D239/96 , C07D409/14 , C07D403/12 , C07D401/12 , C07D417/14 , C07D417/12
CPC分类号： C07D471/04 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P1/00 , A61P11/00 , C07D239/96 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The problem of the present invention is to provide a compound having a superior RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I): [wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.
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公开(公告)号：US09834520B2
公开(公告)日：2017-12-05
申请号：US14775514
申请日：2014-03-13
发明人： Satoshi Yamamoto , Junya Shirai , Yoshiyuki Fukase , Ayumu Sato , Mitsunori Kouno , Yoshihide Tomata , Atsuko Ochida , Kazuko Yonemori , Tsuneo Oda , Tomoya Yukawa
IPC分类号： A61K31/517 , C07D239/72 , C07D239/96 , C07D403/12 , C07D401/12 , C07D409/12 , C07D239/80 , C07D413/12 , C07D417/12 , C07D471/04 , C07D265/36 , C07D217/24 , C07D405/06 , C07D475/04 , C07F7/08
CPC分类号： C07D239/96 , C07D217/24 , C07D239/80 , C07D265/36 , C07D401/12 , C07D403/12 , C07D405/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D475/04 , C07F7/0812
摘要： The present invention provides a heterocyclic compound having an RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein Ar is a the partial structure (1) to the partial structure (5), Q is a bivalent group selected from the group consisting of (Ia)-(If), and B is a ring optionally having substituent(s), or a salt thereof.
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公开(公告)号：US09630924B2
公开(公告)日：2017-04-25
申请号：US15055108
申请日：2016-02-26
发明人： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC分类号： C07D471/04 , C07D215/00 , C07D217/26 , C07F7/08 , C07D491/048 , C07D491/056 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D491/14
CPC分类号： C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
摘要： The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
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公开(公告)号：US20160229814A1
公开(公告)日：2016-08-11
申请号：US14775514
申请日：2014-03-13
发明人： Satoshi Yamamoto , Junya Shirai , Yoshiyuki Fukase , Ayumu Sato , Mitsunori Kouno , Yoshihide Tomata , Atsuko Ochida , Kazuko Yonemori , Tsuneo Oda , Takashi Imada , Tomoya Yukawa
IPC分类号： C07D239/96 , C07D265/36 , C07F7/08 , C07D401/12 , C07D217/24 , C07D417/12 , C07D409/12 , C07D413/12 , C07D475/04 , C07D405/06 , C07D471/04 , C07D403/12
CPC分类号： C07D239/96 , C07D217/24 , C07D239/80 , C07D265/36 , C07D401/12 , C07D403/12 , C07D405/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D475/04 , C07F7/0812
摘要： The present invention provides a heterocyclic compound having an RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein Ar is a the partial structure (1) to the partial structure (5), Q is a bivalent group selected from the group consisting of (Ia)-(If), and B is a ring optionally having substituent(s), or a salt thereof.
摘要翻译： 本发明提供具有RORγt抑制作用的杂环化合物。 本发明涉及由式（I）表示的化合物：其中Ar是部分结构（5）的部分结构（1），Q是选自（Ia） - （If ），B是任选具有取代基的环或其盐。
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