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公开(公告)号：US10406146B2
公开(公告)日：2019-09-10
申请号：US15754934
申请日：2016-08-24
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Akira Kaieda , Naoki Ishii , Hiroshi Nara , Masato Yoshikawa , Masaki Daini
IPC: C07D413/14 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D413/12 , C07D417/14 , C07D471/04 , A61P29/00
Abstract: The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of inflammatory disease and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US10308643B2
公开(公告)日：2019-06-04
申请号：US15210965
申请日：2016-07-15
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Akira Kaieda , Masashi Toyofuku , Masaki Daini , Hiroshi Nara , Masato Yoshikawa , Naoki Ishii , Kousuke Hidaka
IPC: C07D413/14 , C07D413/04 , C07D471/04 , C07D491/08 , C07D491/107 , C07D417/14 , C07D498/08
Abstract: The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a pharmaceutical composition comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US20210277030A1
公开(公告)日：2021-09-09
申请号：US17316185
申请日：2021-05-10
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC: C07F7/08 , C07D205/04 , C07D207/12 , C07K5/065 , C07D239/36 , C07D213/64 , C07D309/06 , C07D333/38 , C07F7/10 , C07D403/06 , C07D271/10 , C07C237/22 , C07D295/14 , C07D207/26 , C07D413/12 , C07F7/30 , C07D233/72 , C07D309/08 , C07D231/56 , C07D261/08 , C07D209/18 , C07D405/12 , C07D261/12 , C07D239/54 , C07D211/62 , C07D237/14 , C07D231/12 , C07D487/04 , A61P43/00 , A61P29/00 , A61P25/00 , A61P19/02 , A61P17/06 , A61P1/04 , C07K5/087
Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US20200010487A1
公开(公告)日：2020-01-09
申请号：US16576293
申请日：2019-09-19
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC: C07F7/08 , C07D205/04 , C07D207/12 , C07K5/065 , C07K5/087
Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US20180319812A1
公开(公告)日：2018-11-08
申请号：US16035277
申请日：2018-07-13
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Satoshi Yamamoto , Junya Shirai , Hiroyuki Watanabe , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Yoshiyuki Fukase , Tomoya Yukawa
IPC: C07D491/056 , C07F7/08 , C07D217/26 , C07D413/12 , C07D401/12 , C07D405/12 , C07D401/04 , C07D413/14 , C07D491/048 , C07D471/04 , C07D417/06 , C07D413/06 , C07D409/06 , C07D405/06 , C07D401/06 , C07D491/04
CPC classification number: C07D491/056 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D491/04 , C07D491/048 , C07F7/0812
Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. wherein each symbol is as defined in the specification.
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Patent Agency Ranking
公开(公告)号：US09365520B2
公开(公告)日：2016-06-14
申请号：US14755439
申请日：2015-06-30
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC: C07D471/04 , C07D215/00 , C07D491/14 , C07D217/26 , C07F7/08 , C07D491/048 , C07D491/056 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14
CPC classification number: C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
Abstract translation: 本发明提供具有RORγt抑制作用的杂环化合物。 本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义。 或其盐。
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公开(公告)号：US11851449B2
公开(公告)日：2023-12-26
申请号：US17316185
申请日：2021-05-10
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC: C07F7/08 , C07D205/04 , C07D207/12 , C07K5/065 , C07D239/36 , C07D213/64 , C07D309/06 , C07D333/38 , C07F7/10 , C07D403/06 , C07D271/10 , C07C237/22 , C07D295/14 , C07D207/26 , C07D413/12 , C07F7/30 , C07D233/72 , C07D309/08 , C07D231/56 , C07D261/08 , C07D209/18 , C07D405/12 , C07D261/12 , C07D239/54 , C07D211/62 , C07D237/14 , C07D231/12 , C07D487/04 , A61P43/00 , A61P29/00 , A61P25/00 , A61P19/02 , A61P17/06 , A61P1/04 , C07K5/087
CPC classification number: C07F7/0812 , A61P1/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P43/00 , C07C237/22 , C07D205/04 , C07D207/12 , C07D207/26 , C07D209/18 , C07D211/62 , C07D213/64 , C07D231/12 , C07D231/56 , C07D233/72 , C07D237/14 , C07D239/36 , C07D239/54 , C07D261/08 , C07D261/12 , C07D271/10 , C07D295/14 , C07D309/06 , C07D309/08 , C07D333/38 , C07D403/06 , C07D405/12 , C07D413/12 , C07D487/04 , C07F7/081 , C07F7/10 , C07F7/30 , C07K5/06078 , C07K5/0812
Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US11053262B2
公开(公告)日：2021-07-06
申请号：US16576293
申请日：2019-09-19
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC: C07F7/08 , C07D309/06 , C07D405/12 , C07D239/36 , C07D413/12 , C07D205/04 , C07C237/22 , C07D207/12 , C07D271/10 , C07F7/10 , C07F7/30 , C07K5/065 , C07D309/08 , C07D231/12 , C07D231/56 , C07D333/38 , C07D233/72 , C07D403/06 , C07D237/14 , C07D239/54 , C07D213/64 , C07D295/14 , C07D207/26 , C07D261/08 , C07D209/18 , C07D261/12 , C07D211/62 , C07D487/04 , A61P43/00 , A61P29/00 , A61P25/00 , A61P19/02 , A61P17/06 , A61P1/04 , C07K5/087
Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US20170050974A1
公开(公告)日：2017-02-23
申请号：US14902309
申请日：2014-07-02
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Satoshi Yamamoto , Junya Shirai , Hiroyuki Watanabe , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Yoshiyuki Fukase , Tomoya Yukawa
IPC: C07D491/056 , C07D471/04
CPC classification number: C07D491/056 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D491/04 , C07D491/048 , C07F7/0812
Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. wherein each symbol is as defined in the specification.
Abstract translation: 其中每个符号如说明书中所定义。
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公开(公告)号：US10472376B2
公开(公告)日：2019-11-12
申请号：US14902388
申请日：2014-07-02
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC: C07F7/08 , C07D309/06 , C07D405/12 , C07D239/36 , C07D413/12 , C07D205/04 , C07C237/22 , C07D207/12 , C07D271/10 , C07F7/10 , C07F7/30 , C07K5/065 , C07D309/08 , C07D231/12 , C07D231/56 , C07D333/38 , C07D233/72 , C07D403/06 , C07D237/14 , C07D239/54 , C07K5/087
Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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