公开(公告)号：US20210269420A1

公开(公告)日：2021-09-02

申请号：US17256330

申请日：2019-06-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tatsuhiko FUJIMOTO ,  Koichiro FUKUDA ,  Hiromichi SUGIMOTO ,  Kentaro RIKIMARU ,  Yoshihiro BANNO ,  Takahiro MATSUMOTO ,  Norihito TOKUNAGA ,  Yoshihide TOMATA ,  Yuji ISHICHI ,  Shogo MARUI ,  Tsuneo ODA ,  Tohru MIYAZAKI ,  Yasutaka HOASHI ,  Yasushi HATTORI ,  Yuichi KAJITA ,  Yuhei MIYANOHANA ,  Tatsuki KOIKE

IPC: C07D401/14 ,  C07D405/14 ,  C07D211/56

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US20160176872A1

公开(公告)日：2016-06-23

申请号：US15055108

申请日：2016-02-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D471/04

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.

Abstract translation: 本发明提供具有RORγt抑制作用的杂环化合物。 本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义。 或其盐。

公开(公告)号：US20170253591A1

公开(公告)日：2017-09-07

申请号：US15510225

申请日：2015-09-10

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Takashi IMADA ,  Mitsunori KONO ,  Ayumu SATO ,  Yoshihide TOMATA ,  Atsuko OCHIDA ,  Naoki ISHII ,  Yusuke SASAKI ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D471/04 ,  C07D413/12 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D239/96 ,  C07D409/14 ,  C07D403/12 ,  C07D401/12 ,  C07D417/14 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D471/04 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61P1/00 ,  A61P11/00 ,  C07D239/96 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: The problem of the present invention is to provide a compound having a superior RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I): [wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.

公开(公告)号：US20160002169A1

公开(公告)日：2016-01-07

申请号：US14755439

申请日：2015-06-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D217/26 ,  C07D491/056 ,  C07D491/048 ,  C07F7/08 ,  C07D471/04

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.

公开(公告)号：US20170144973A1

公开(公告)日：2017-05-25

申请号：US15321609

申请日：2015-06-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D217/26 ,  C07D491/056 ,  C07D491/048 ,  C07F7/08 ,  C07D471/04

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: Provided are heterocyclic compounds having a RORγt inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20160176873A1

公开(公告)日：2016-06-23

申请号：US15055156

申请日：2016-02-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D471/04

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.

公开(公告)号：US20160176822A1

公开(公告)日：2016-06-23

申请号：US15055197

申请日：2016-02-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D217/26

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.