公开(公告)号：US20210060210A1

公开(公告)日：2021-03-04

申请号：US16982179

申请日：2019-03-18

Applicant: Kyoto University ,  Takeda Pharmaceutical Company Limited

Inventor： Taro TOYODA ,  Taisuke MOCHIDA ,  Yutaka TANOUE ,  Ryo ITO ,  Koya KIMOTO ,  Yusuke KOIKE ,  Hikaru UENO

IPC: A61L27/38 ,  A61K9/06 ,  A61K47/36 ,  A61L27/36 ,  A61P3/10 ,  A61L27/54 ,  A61L27/20 ,  A61K35/39 ,  C12N5/071

Abstract: An object of the present invention is to provide a method for removing highly proliferative Ki67-positive cells co-present in insulin-secreting cells obtained by differentiation induction. A method for producing an insulin-producing cell population or a pancreatic beta cell population containing less than 3% of Ki67-positive cells, comprising: embedding an endocrine progenitor cell population or a cell population at a later stage of differentiation into a gel containing alginic acid; and differentiating the cell population.

公开(公告)号：US20160310412A1

公开(公告)日：2016-10-27

申请号：US15104642

申请日：2014-12-15

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yutaka TANOUE ,  Yumiko ISHII ,  Yoshihiro OMACHI ,  Tomoyuki MANOSHIRO

IPC: A61K9/00 ,  A61K39/12 ,  A61K47/40 ,  A61K47/26 ,  A61K47/36 ,  A61K39/08 ,  C12N7/00

CPC classification number: A61K9/0021 ,  A61K39/08 ,  A61K39/12 ,  A61K47/26 ,  A61K47/36 ,  A61K47/40 ,  A61K2039/5258 ,  A61K2039/54 ,  C12N7/00 ,  C12N2770/16023 ,  C12N2770/16034 ,  Y02A50/386

Abstract: In order to configure a microneedle to be more suitable for administering a vaccine antigen, the present invention is a formulation having a dissolving-type microspike which is used as a microneedle in which a vaccine antigen is stabilized, and which includes a vaccine antigen, an ionic polymer base material, and at least one species selected from the group consisting of a non-reducing sugar, a sugar alcohol, cyclodextrin, and a surfactant.

Abstract translation: 为了将微针配置为更适合于施用疫苗抗原，本发明是具有溶解型小珠的制剂，其用作疫苗抗原稳定化的微针，其包含疫苗抗原， 离子聚合物基材，以及选自非还原糖，糖醇，环糊精和表面活性剂中的至少一种。