公开(公告)号：US20200041451A1

公开(公告)日：2020-02-06

申请号：US16339348

申请日：2017-10-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Noel Seunghyun Ha ,  R. Michael Van Dam ,  Jimmy Ly

IPC: G01N27/447 ,  B01L3/00 ,  G01N27/453

Abstract: A volumetric microfluidic injector for capillary electrophoresis (CE) for highly repeatable sample injection has been designed and built to eliminate known injection bias in hydrodynamic injection. A defined volume from 1-10 nL or 0.1-100 nL of sample is confined in a defined region of a micro-valve PDMS microfluidic injector chip and electrophoretic potential is applied to drive sample into a separation device such as an embedded fused silica capillary for separation and detection. Using a 75 μm ID capillary, the RSD of an absorbance peak area as low as 1.32% (n=11) is obtained. As a comparison, the time-dependent injection was tested using the same chip which resulted in an inferior repeatability.

公开(公告)号：US11660571B2

公开(公告)日：2023-05-30

申请号：US16461272

申请日：2017-11-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： R. Michael van Dam ,  Noel S. Ha ,  Jason Jones ,  Jimmy Ly ,  Stephen Liu ,  Shilin Cheung

IPC: B01D57/02 ,  G01N27/447 ,  A61K51/00 ,  B01L3/00

CPC classification number: B01D57/02 ,  A61K51/00 ,  B01L3/502715 ,  B01L3/502738 ,  G01N27/44717 ,  G01N27/44721 ,  G01N27/44743 ,  G01N27/44791

Abstract: A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.

公开(公告)号：US11209390B2

公开(公告)日：2021-12-28

申请号：US16339348

申请日：2017-10-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Noel Seunghyun Ha ,  R. Michael Van Dam ,  Jimmy Ly

IPC: G01N27/447 ,  B01L3/00 ,  G01N27/453

Abstract: A volumetric microfluidic injector for capillary electrophoresis (CE) for highly repeatable sample injection has been designed and built to eliminate known injection bias in hydrodynamic injection. A defined volume from 1-10 nL or 0.1-100 nL of sample is confined in a defined region of a micro-valve PDMS microfluidic injector chip and electrophoretic potential is applied to drive sample into a separation device such as an embedded fused silica capillary for separation and detection. Using a 75 μm ID capillary, the RSD of an absorbance peak area as low as 1.32% (n=11) is obtained. As a comparison, the time-dependent injection was tested using the same chip which resulted in an inferior repeatability.

公开(公告)号：US20200147548A1

公开(公告)日：2020-05-14

申请号：US16461272

申请日：2017-11-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： R. Michael van Dam ,  Noel S. Ha ,  Jason Jones ,  Jimmy Ly ,  Stephen Liu ,  Shilin Cheung

IPC: B01D57/02 ,  A61K51/00

Abstract: A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.