专利检索 ap:("TRANSBIO LTD" OR "THE UNIVERSITY OF QUEENSLAND" OR "THE REGENTS OF THE UNIVERSITY OF CALIFORNIA") AND inv:"James D. Marks" 第 1 页

1.

发明申请
ANTI-CD83 ANTIBODIES AND USE THEREOF 有权
标题翻译：抗CD83抗体及其用途

公开(公告)号：US20150376277A1

公开(公告)日：2015-12-31

申请号：US14765236

申请日：2014-01-31

申请人： TRANSBIO LTD , THE UNIVERSITY OF QUEENSLAND , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Therese Ann Seldon , David John Munster , Derek Nigel John Hart , Martina Louise Jones , Trent Phillip Munro , Stephen Michael Mahler , Eunice Yu Zhou , James D. Marks

IPC分类号： C07K16/28

CPC分类号： C07K16/2803 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/32 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/72 , C07K2317/732 , C07K2317/92

摘要： The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis.

摘要翻译： 本公开涉及结合CD83的蛋白质及其用途，例如在治疗，预防，诊断或预后中。

2.

发明授权
Anti-CD83 antibodies and use thereof 有权

公开(公告)号：US09840559B2

公开(公告)日：2017-12-12

申请号：US14765236

申请日：2014-01-31

申请人： DENDROCYTE BIOTECH PTY LTD , THE UNIVERSITY OF QUEENSLAND , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Therese Ann Seldon , David John Munster , Derek Nigel John Hart , Martina Louise Jones , Trent Phillip Munro , Stephen Michael Mahler , Eunice Yu Zhou , James D. Marks

IPC分类号： C07K16/28 , A61K39/00

CPC分类号： C07K16/2803 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/32 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/72 , C07K2317/732 , C07K2317/92

摘要： The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis.

3.

发明授权
Anti-CD83 antibodies and use thereof 有权

公开(公告)号：US11725054B2

公开(公告)日：2023-08-15

申请号：US16924860

申请日：2020-07-09

申请人： KIRA BIOTECH PTY LIMITED , THE UNIVERSITY OF QUEENSLAND , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Therese Ann Seldon , David John Munster , Derek Nigel John Hart , Martina Louise Jones , Trent Phillip Munro , Stephen Michael Mahler , Yu Zhou , James D. Marks

IPC分类号： C07K16/28 , A61K39/00

CPC分类号： C07K16/2803 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/32 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/72 , C07K2317/732 , C07K2317/92

摘要： The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis.

4.

发明申请
ANTI-CD83 ANTIBODIES AND USE THEREOF 审中-公开

公开(公告)号：US20180201681A1

公开(公告)日：2018-07-19

申请号：US15808423

申请日：2017-11-09

申请人： DENDROCYTE BIOTECH PTY LTD , THE UNIVERSITY OF QUEENSLAND , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Therese Ann Seldon , David John Munster , Derek Nigel John Hart , Martina Louise Jones , Trent Phillip Munro , Stephen Michael Mahler , Yu Zhou , James D. Marks

IPC分类号： C07K16/28 , A61K39/00

摘要： The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis or prognosis.

5.

发明申请
ANTI-CD83 ANTIBODIES AND USE THEREOF 审中-公开

公开(公告)号：US20200339684A1

公开(公告)日：2020-10-29

申请号：US16924860

申请日：2020-07-09

申请人： DENDROCYTE BIOTECH PTY LTD , THE UNIVERSITY OF QUEENSLAND , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Therese Ann Seldon , David John Munster , Derek Nigel John Hart , Martina Louise Jones , Trent Phillip Munro , Stephen Michael Mahler , Yu Zhou , James D. Marks

IPC分类号： C07K16/28

摘要： The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis.

6.

发明授权
Anti-CD83 antibodies and use thereof 有权

公开(公告)号：US10781255B2

公开(公告)日：2020-09-22

申请号：US15808423

申请日：2017-11-09

申请人： DENDROCYTE BIOTECH PTY LTD , THE UNIVERSITY OF QUEENSLAND , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Therese Ann Seldon , David John Munster , Derek Nigel John Hart , Martina Louise Jones , Trent Phillip Munro , Stephen Michael Mahler , Yu Zhou , James D. Marks

IPC分类号： C07K16/28 , A61K39/00

摘要： The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis or prognosis.

7.

发明申请
ANTIBODIES THAT BIND INTEGRIN AVB8 AND USES THEREOF 有权

公开(公告)号：US20210277125A1

公开(公告)日：2021-09-09

申请号：US17151009

申请日：2021-01-15

申请人： The Regents of the University of California

发明人： Stephen L. Nishimura , Anthony Cormier , Saburo Ito , Jianlong Lou , James D. Marks , Yifan Cheng , Melody G. Campbell , Jody L. Baron

IPC分类号： C07K16/28

摘要： Antibodies that bind to αv⊖8 are provided.

8.

发明授权
Neutralizing antibodies to the αvβ8 integrin complex for immunotherapy 有权

公开(公告)号：US10954304B2

公开(公告)日：2021-03-23

申请号：US16331902

申请日：2017-09-29

申请人： The Regents of the University of California

发明人： Stephen L. Nishimura , Jianlong Lou , James D. Marks , Jody L. Baron , Yifan Cheng , Shenping Wu , Anthony Cormier , Naoki Takasaka

IPC分类号： C07K16/00 , C07K16/46 , C07K16/28 , A61P31/20 , A61P35/04 , A61P37/04 , A61P1/04 , C07K14/705 , C07K16/22 , G01N33/563 , A61K39/00

摘要： Provided is an antibody that specifically binds human αvββ and blocks binding of TGFp peptide to αvβ8, wherein the antibody binds to the specificity determining loop (SDL) of human β8. In some embodiments, the antibody further binds to one, two, or all three of the human av-head domain, the al helix of human β8, or the al helix of human β8. In some embodiments, the antibody is humanized or chimeric. In some embodiments, the antibody is linked to a detectable label. Also provided is a method of enhancing an immune response in a human individual, comprising administering a sufficient amount of the antibody to the individual, thereby enhancing an immune response. Also provided are pharmaceutical compositions comprising the anti-αvββ antibodies or antigen-binding molecules thereof.

9.

发明申请
Protein A Binding Polypeptides, Anti-EphA2 Antibodies and Methods of Use Thereof 审中-公开

公开(公告)号：US20170267768A1

公开(公告)日：2017-09-21

申请号：US15457857

申请日：2017-03-13

申请人： The Regents of the University of California , Merrimack Pharmaceuticals, Inc.

发明人： James D. Marks , Daryl Drummond , Melissa Geddie , Dmitri Kirpotin , Neeraj Kohli , Alexey Lugovskoy

IPC分类号： C07K16/28 , C07K16/12

CPC分类号： C07K16/2866 , A61K47/6913 , A61K2039/505 , A61K2039/55555 , C07K16/1271 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/77 , C07K2317/94

摘要： Provided by the present disclosure are antibodies (e.g., scFvs) that include CDRs and human framework regions that confer useful properties upon the antibodies. In certain embodiments, such properties include thermostability (e.g., increased melting temperature), efficient binding to Staphylococcus aureus Protein A, or both. In certain aspects, the antibodies are internalizing antibodies that specifically bind to the tumor associated antigen EphA2.