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    SILK-BASED DRUG DELIVERY SYSTEM
    2.
    发明申请
    SILK-BASED DRUG DELIVERY SYSTEM 审中-公开
    基于SILK的药物递送系统

    公开(公告)号：US20130177611A1

    公开(公告)日：2013-07-11

    申请号：US13783485

    申请日：2013-03-04

    申请人： TRUSTEES OF TUFTS COLLEGE ,  Eidgenossisches Techinsche Hochschule (The Swiss Federal Institute of Technology)

    发明人： David L. Kaplan ,  Lorenz Meinel

    IPC分类号： A61K47/42 ,  A61K9/00

    CPC分类号： A61K47/42 ,  A61K9/0002 ,  A61K9/7007 ,  A61K31/00 ,  A61K47/46

    摘要： The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crystallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer.

    摘要翻译： 本发明提供了新颖的持续释放的基于丝的递送系统。 本发明还提供了生产这种制剂的方法。 通常，将丝素蛋白溶液与治疗剂组合以形成丝素蛋白制品。 然后对该文章进行处理，以改变其构象。 构象的变化增加其结晶度或液晶性，从而控制治疗剂从制剂中的释放。 这可以作为单一材料载体或以逐层方式实现，以在每个层中加载不同的治疗剂或不同浓度的这些试剂。

    Silk-based drug delivery system
    6.
    发明授权
    Silk-based drug delivery system 有权

    公开(公告)号：US10548981B2

    公开(公告)日：2020-02-04

    申请号：US14095366

    申请日：2013-12-03

    申请人： TRUSTEES OF TUFTS COLLEGE ,  EIDGENOSSISCHES TECHNISCHE HOCHSCHULE (THE SWISS FEDERAL INSTITUTE OF TECHNOLOGY)

    发明人： David L. Kaplan ,  Lorenz Meinel

    IPC分类号： A61K9/24 ,  A61K9/00 ,  A61K47/42

    摘要： The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crystallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer.

    SILK-BASED DRUG DELIVERY SYSTEM
    9.
    发明申请
    SILK-BASED DRUG DELIVERY SYSTEM 审中-公开
    基于SILK的药物递送系统

    公开(公告)号：US20140093580A1

    公开(公告)日：2014-04-03

    申请号：US14095366

    申请日：2013-12-03

    申请人： Eidgenossisches Technische Hochschule (The Swiss Federal Institute Of Technology) ,  Trustees Of Tufts College

    发明人： David L. Kaplan ,  Lorenz Meinel

    IPC分类号： A61K47/42

    摘要： The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crystallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer.

    摘要翻译： 本发明提供了新颖的持续释放的基于丝的递送系统。 本发明还提供了生产这种制剂的方法。 通常，将丝素蛋白溶液与治疗剂组合以形成丝素蛋白制品。 然后对该文章进行处理，以改变其构象。 构象的变化增加其结晶度或液晶性，从而控制治疗剂从制剂中的释放。 这可以作为单一材料载体或以逐层方式实现，以在每个层中加载不同的治疗剂或不同浓度的这些试剂。