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    Nitric oxide sensor
    1.
    发明授权
    Nitric oxide sensor 失效
    一氧化氮传感器

    公开(公告)号：US5603820A

    公开(公告)日：1997-02-18

    申请号：US477620

    申请日：1995-06-07

    申请人： Tadeusz Malinski ,  David A. Wink ,  Janet Younathan ,  Royce W. Murray ,  Melani Sullivan ,  Thomas J. Meyer ,  Danae D. Christodoulou

    发明人： Tadeusz Malinski ,  David A. Wink ,  Janet Younathan ,  Royce W. Murray ,  Melani Sullivan ,  Thomas J. Meyer ,  Danae D. Christodoulou

    IPC分类号： B01J31/16 ,  B01J31/18 ,  G01N27/30 ,  G01N27/416 ,  G01N33/00 ,  G01N27/26

    CPC分类号： B01J31/1815 ,  B01J31/1658 ,  G01N27/4045 ,  B01J2531/025 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847

    摘要： An electrode sensor which may be used to specifically and quantitatively measure nitric oxide is provided, as well as a method of preparing and using such an electrode sensor to measure nitric oxide concentration in solution. A nitric oxide (NO) microsensor based on catalytic oxidation of NO comprises a thermally-sharpened carbon fiber with a tip diameter of about 0.5-0.7 .mu.m coated with several layers of p-type semiconducting polymeric porphyrin and cationic exchanger deposited thereon. The microsensor, which can be operated in either the amperometric, voltammetric or coulometric mode utilizing a two or three electrode system, is characterized by a linear response up to about 300 .mu.M, a response time better than 10 msec and a detection limit of about 10 nM. The sensor of the present invention also discriminates against nitrite, the most problematic interferant in NO measurements. The amount of NO released from a single cell can thus be selectively measured in situ by a porphyrinic microsensor of the invention. A larger scale sensor utilizing porphyrin and cationic exchanger deposited on larger fibers or wires, platinum mesh or tin indium oxide layered on glass, can also be employed when measurement of NO concentration in chemical media, tissue or cell culture is desired.

    摘要翻译： 提供了可用于特异性和定量测量一氧化氮的电极传感器，以及制备和使用这种电极传感器来测量溶液中的一氧化氮浓度的方法。 基于NO的催化氧化的一氧化氮（NO）微量传感器包括具有约0.5-0.7μm的尖锐直径的碳纤维，其涂覆有几层p型半导体聚合物卟啉和沉积在其上的阳离子交换剂。 可以使用两个或三个电极系统以电流，伏安或库仑模式操作的微传感器的特征在于线性响应高达约300μM，响应时间优于10msec，检测限为约 10nM。 本发明的传感器还可以区分NO测量中最有问题的干扰物亚硝酸盐。 因此，可以通过本发明的卟啉微传感器原位选择性地测量从单个电池释放的NO的量。 当需要在化学介质，组织或细胞培养物中测量NO浓度时，也可以使用沉积在较大纤维或电线上的卟啉和阳离子交换剂的更大规模的传感器，铂玻璃或层状玻璃上的氧化铟锡。

    Nitroxyl Progenitors in the Treatment of Heart Failure
    4.
    发明申请
    Nitroxyl Progenitors in the Treatment of Heart Failure 审中-公开
    硝酸基因祖细胞治疗心力衰竭

    公开(公告)号：US20110081427A1

    公开(公告)日：2011-04-07

    申请号：US12949533

    申请日：2010-11-18

    申请人： David A. Wink ,  Martin Feelisch ,  David A. Kass ,  Nazareno Paolocci ,  Katrina Miranda ,  Jon Fukuto ,  Tatsuo Katori

    发明人： David A. Wink ,  Martin Feelisch ,  David A. Kass ,  Nazareno Paolocci ,  Katrina Miranda ,  Jon Fukuto ,  Tatsuo Katori

    IPC分类号： A61K33/00 ,  A61P9/04 ,  A61K31/655

    CPC分类号： A61K31/655 ,  A61K31/13 ,  A61K31/16 ,  A61K33/00 ,  A61K2300/00

    摘要： Administration of an HNO/NO− donating compound, such as Angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart failure. Moreover, administration of the HNO/NO− donating compound isopropylamine (IPA)/NO (Na(CH3)2CHNHN(O)NO) surprisingly exhibited positive inotropic effects in subjects experiencing heart failure that were superior to those caused by the HNO/NO− donating compound Angeli's salt. Additionally, in contrast to the effects observed with NO− donors, administration of an HNO/NO− donor in combination with a positive inotropic agent did not impair the positive inotropic effect of the positive inotropic agent. Further, HNO/NO− exerts its positive inotropic effect independent of the adrenergic system, increasing contractility even in subjects receiving beta-antagonist therapy.

    摘要翻译： 施用HNO / NO供体化合物，例如Angeli盐可增加心肌收缩力，同时降低心衰患者的左心室预负荷。 此外，HNO / NO供体化合物异丙胺（IPA）/ NO（Na（CH 3）2 CHNHN（O）NO）的给药令人惊讶地在经历心力衰竭的受试者中表现出优于HNO / NO- 捐赠化合物Angeli的盐。 另外，与使用NO-供体观察到的效果相反，将HNO / NO供体与正性肌力药物联合给药不会损害正性肌力药物的正性肌力作用。 此外，HNO / NO-不依赖于肾上腺素能系统发挥其正性肌力作用，即使在接受β-拮抗剂治疗的受试者中也能增加收缩力。