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公开(公告)号：US06562618B1
公开(公告)日：2003-05-13
申请号：US09582337
申请日：2000-09-18
IPC分类号： C07K1622
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2267/01 , A01K2267/03 , A61K2039/505 , C07K14/475 , C07K16/22 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , G01N2800/347 , Y10S435/81
摘要： A human monoclonal antibody useful for the treatment of various diseases caused by human connective tissue growth factor (CTGF) and preventing the onset of the above diseases; medicinal uses thereof; and various monoclonal antibodies having various characteristics against various mammalian CTGFs useful for detecting and assaying CTGFs present in body fluids of mammals suffering from various diseases.
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2.发明授权Monoclonal antibody against connective tissue growth factor and medicinal uses thereof 失效针对结缔组织生长因子的单克隆抗体及其药物用途公开(公告)号：US07541438B2
公开(公告)日：2009-06-02
申请号：US11324769
申请日：2006-01-04
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2267/01 , A01K2267/03 , A61K2039/505 , C07K14/475 , C07K16/22 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , G01N2800/347 , Y10S435/81
摘要： A human monoclonal antibody useful for the treatment of various diseases caused by human connective tissue growth factor (CTGF) and preventing the onset of the above diseases; medicinal uses thereof; and various monoclonal antibodies having various characteristics against various mammalian CTGFs useful for detecting and assaying CTGFs present in body fluids of mammals suffering from various diseases.
摘要翻译： 用于治疗由人结缔组织生长因子（CTGF）引起的各种疾病并预防上述疾病发作的人单克隆抗体; 药用 以及针对各种可用于检测和测定存在于患有各种疾病的哺乳动物的体液中的CTGF的各种哺乳动物CTGF的各种特征的各种单克隆抗体。
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公开(公告)号：US20060223133A1
公开(公告)日：2006-10-05
申请号：US11324769
申请日：2006-01-04
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2267/01 , A01K2267/03 , A61K2039/505 , C07K14/475 , C07K16/22 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , G01N2800/347 , Y10S435/81
摘要： A human monoclonal antibody useful for the treatment of various diseases caused by human connective tissue growth factor (CTGF) and preventing the onset of the above diseases; medicinal uses thereof; and various monoclonal antibodies having various characteristics against various mammalian CTGFs useful for detecting and assaying CTGFs present in body fluids of mammals suffering from various diseases.
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公开(公告)号：US08399466B2
公开(公告)日：2013-03-19
申请号：US12782514
申请日：2010-05-18
申请人： Masaharu Takigawa , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
发明人： Masaharu Takigawa , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
IPC分类号： A61K31/495 , A61K31/435 , A61K31/38
CPC分类号： A61K31/27 , A61K9/1647 , A61K31/277 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4166 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61K31/4453 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551
摘要： A composition for regenerative treatment of cartilage disease, which comprises a PDE4 inhibitor as an active ingredient, specifically a composition comprising a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suited to administer locally to affected cartilage region, such as microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in regenerative treatment of cartilage.
摘要翻译： 提供了一种用于软骨疾病的再生治疗的组合物，其包含PDE4抑制剂作为活性成分，特别是包含PDE4抑制剂和生物相容性和生物可降解聚合物的组合物，该组合物当配制成适于局部施用于受影响软骨的形式时 可以提供在软骨的再生处理中显示出极好的效果的药物组合物，例如微球制剂。
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公开(公告)号：US08252794B2
公开(公告)日：2012-08-28
申请号：US11707008
申请日：2007-02-16
申请人： Masaharu Takigawa , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
发明人： Masaharu Takigawa , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
IPC分类号： A61K31/495 , A61K31/435 , A61K31/38
CPC分类号： A61K31/27 , A61K9/1647 , A61K31/277 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4166 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61K31/4453 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551
摘要： A composition for regenerative treatment of cartilage disease, which comprises a PDE4 inhibitor as an active ingredient, specifically a composition comprising a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suited to administer locally to affected cartilage region, such as microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in regenerative treatment of cartilage.
摘要翻译： 提供了一种用于软骨疾病的再生治疗的组合物，其包含PDE4抑制剂作为活性成分，特别是包含PDE4抑制剂和生物相容性和生物可降解聚合物的组合物，该组合物当配制成适于局部施用于受影响软骨的形式时 可以提供在软骨的再生处理中显示出极好的效果的药物组合物，例如微球制剂。
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6.发明授权
公开(公告)号：US6080720A
公开(公告)日：2000-06-27
申请号：US505539
申请日：1995-07-21
申请人： Akira Kudo , Tohru Nakanishi , Masaharu Takigawa
发明人： Akira Kudo , Tohru Nakanishi , Masaharu Takigawa
CPC分类号： A61K38/185
摘要： This invention relates to a composition for metabolic bone diseaese and/or bone fractures which comprises a pharmaceutically acceptable carrier and human neurotrophin-3 (NT-3).This invention also relates to a method for the treatment and/or prevention of metabolic bone diseaese or bone fractures which comprises administering to a patient in need of said treatment and/or prevention a medicament containing an effective amount of human neurotrophin-3 (NT-3).
摘要翻译： 本发明涉及一种用于代谢性骨病和/或骨折的组合物，其包含药学上可接受的载体和人神经营养因子-3（NT-3）。 本发明还涉及用于治疗和/或预防代谢性骨病或骨折的方法，其包括向需要所述治疗和/或预防的患者施用含有有效量的人神经营养因子-3（NT- 3）。
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公开(公告)号：US20070155652A1
公开(公告)日：2007-07-05
申请号：US11707008
申请日：2007-02-16
申请人： Masaharu Takigawa , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
发明人： Masaharu Takigawa , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
IPC分类号： A61K38/39
CPC分类号： A61K31/27 , A61K9/1647 , A61K31/277 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4166 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61K31/4453 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551
摘要： A composition for regenerative treatment of cartilage disease, which comprises a PDE4 inhibitor as an active ingredient, specifically a composition comprising a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suited to administer locally to affected cartilage region, such as microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in regenerative treatment of cartilage.
摘要翻译： 提供了一种用于软骨疾病的再生治疗的组合物，其包含PDE4抑制剂作为活性成分，特别是包含PDE4抑制剂和生物相容性和生物可降解聚合物的组合物，该组合物当配制成适于局部施用于受影响软骨的形式时 可以提供在软骨的再生处理中显示出极好的效果的药物组合物，例如微球制剂。
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公开(公告)号：US5440012A
公开(公告)日：1995-08-08
申请号：US952735
申请日：1992-11-30
IPC分类号： A61K38/23 , A61K38/00 , A61P5/12 , C07K1/00 , C07K14/435 , C07K14/575 , C07K14/585
CPC分类号： C07K14/585 , A61K38/00
摘要： A calcitonin originated from the ultimobranchial gland of cartilaginous fishes and having a blood calcium-decreasing activity has the following amino acid sequence: H-Cys-Thr-Ser-Leu-Ser-Thr-Cys-Val-Val-Gly-Lys-Leu-Ser-Gln-Gln-Leu-His-Lys-Leu-Gln-Asn-Ile-Gln-Arg-Thr-Asp-Val-Gly-Ala-Ala-Thr-Pro-NH.sub.2, where the cysteine residues in the peptide may be linked together through a disulfide bond. The novel peptide exhibits an excellent blood calcium-decreasing activity and an excellent chondrocyte differentiation-promoting activity and is useful as a therapeutic agent for hypercalcemia, osteoporosis, Paget's disease, and the like.
摘要翻译： PCT No.PCT / JP92 / 00706 Sec。 371日期：1992年11月30日 102（e）日期1992年11月30日PCT提交1992年5月29日PCT公布。 WO92 / 21700 PCT出版物 日期：1992年10月12日。降钙素源自软骨鱼的最终支气管，具有降血糖活性，具有以下氨基酸序列：H-Cys-Thr-Ser-Leu-Ser-Thr-Cys-Val- Val-Gly-Lys-Leu-Ser-Gln-Gln-Leu-His-Lys-Leu-Gln-Asn-Ile-Gln-Arg-Thr-Asp-Val-Gly-Ala-Ala-Thr-Pro-NH2， 其中肽中的半胱氨酸残基可以通过二硫键连接在一起。 该新型肽显示出优异的血液钙降低活性和优异的软骨细胞分化促进活性，可用作高钙血症，骨质疏松症，佩吉特氏病等的治疗剂。
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