公开(公告)号：US6080720A

公开(公告)日：2000-06-27

申请号：US505539

申请日：1995-07-21

申请人： Akira Kudo ,  Tohru Nakanishi ,  Masaharu Takigawa

发明人： Akira Kudo ,  Tohru Nakanishi ,  Masaharu Takigawa

IPC分类号： A61K38/00 ,  A61K38/18 ,  A61K38/22 ,  A61P19/08 ,  A61P43/00

CPC分类号： A61K38/185

摘要： This invention relates to a composition for metabolic bone diseaese and/or bone fractures which comprises a pharmaceutically acceptable carrier and human neurotrophin-3 (NT-3).This invention also relates to a method for the treatment and/or prevention of metabolic bone diseaese or bone fractures which comprises administering to a patient in need of said treatment and/or prevention a medicament containing an effective amount of human neurotrophin-3 (NT-3).

摘要翻译： 本发明涉及一种用于代谢性骨病和/或骨折的组合物，其包含药学上可接受的载体和人神经营养因子-3（NT-3）。 本发明还涉及用于治疗和/或预防代谢性骨病或骨折的方法，其包括向需要所述治疗和/或预防的患者施用含有有效量的人神经营养因子-3（NT- 3）。

公开(公告)号：US4786719A

公开(公告)日：1988-11-22

申请号：US790970

申请日：1985-10-24

申请人： Akira Kudo ,  Yushi Nishimura ,  Yataro Ichikawa ,  Takeshi Watanabe

发明人： Akira Kudo ,  Yushi Nishimura ,  Yataro Ichikawa ,  Takeshi Watanabe

IPC分类号： C12N15/09 ,  A61K39/395 ,  C07K16/30 ,  C12P21/08 ,  C12R1/91 ,  C07H19/10 ,  C07H19/20 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K16/3061 ,  Y10S530/867

摘要： A DNA sequence comprising a polynucleotide segment consisting of a DNA sequence (A) shown below and a DNA sequence complementary thereto: ##STR1## wherein A represents deoxyadenosine-5'-phosphate, C represents deoxycytidine-5'-phosphate, G represents deoxyguanosine-5'-phosphate, and T represents deoxythymidine-5'-phosphate.The DNA sequence provided by this invention is derived from a rearranged immunoglobulin heavy chain variable (V.sub.H) region gene taken from the mouse hybridoma NL-1 cells which produce an antibody capable of commonly recognizing surface antigens of various human acute lyphocytic leukemia cells. Accordingly, if, for example, it is combined with a heavy chain constant (C.sub.H) region gene, a heavy chain can be produced which can recognize commonly various human acute lymphocytic leukemia cells in combination with a proper light chain. This would serve for the diagnosis and treatment of human acute lymphocytic leukemia.

摘要翻译： 包含多核苷酸段，其由以下所示的DNA序列（A）和与其互补的DNA序列的DNA序列：GATGTGCAGCTGGTGGAGTCTGGGGGAGGCTTA + TR GTGCAGCCT GGAGGGTCCCGGAAACTCTCCTGTGCAGCCTCT + TR GGATTCACT TTCAGTAGCTTTGGAATGCACTGGGTTCGTCAG + TR GCTCCAGAG AAGGGGCTGGAGTGGGTCGCATATATTAGTGGT + TR GGCAGTTAT ACCATCTACTATGCAGACACAGTGAAGGGCCGA + TR TTCACCATC TCCAGAGACAATCCCAAGAACACCCTGTTCCTA + TR CAAATGACC AGTCTAAGGTCTGAGGACACGGCCATGTATTAC + TR TGTGCAAGT TCCTATGGTAACTTCTGGTACTTCGATGTCTGG + TR GGCGCAGGG ACCACGGTCACCGTCTCCTCA其中A代表脱氧腺苷-5'-磷酸，C代表脱氧胞苷-5'-磷酸，G代表脱氧鸟苷-5'-磷酸，T代表脱氧胸苷-5'-磷酸。 本发明提供的DNA序列衍生自取自小鼠杂交瘤NL-1细胞的重排免疫球蛋白重链可变（VH）区域基因，其产生能够通常识别各种人类急性淋巴细胞白血病细胞表面抗原的抗体。 因此，如果例如与重链恒定（CH）区域基因组合，则可以产生可以将合适的各种人类急性淋巴细胞白血病细胞与适当的轻链结合的重链。 这将用于诊断和治疗人类急性淋巴细胞性白血病。

公开(公告)号：US20120152018A1

公开(公告)日：2012-06-21

申请号：US13329159

申请日：2011-12-16

申请人： Akira Kudo ,  Chen Qian

发明人： Akira Kudo ,  Chen Qian

IPC分类号： G01L7/20

CPC分类号： G01L9/0008 ,  G01L9/085

摘要： An atmospheric pressure estimation method is disclosed. The method includes: controlling an oscillation frequency of a predetermined oscillator to match an oscillation frequency of an atmospheric pressure measurement oscillator; detecting a phase difference between an oscillation signal of the predetermined oscillator and an oscillation signal of the atmospheric pressure measurement oscillator; and estimating atmospheric pressure using the oscillation frequency of the predetermined oscillator and the phase difference.

摘要翻译： 公开了一种大气压力估计方法。 该方法包括：控制预定振荡器的振荡频率以匹配大气压测量振荡器的振荡频率; 检测所述预定振荡器的振荡信号与所述大气压测量振荡器的振荡信号之间的相位差; 并使用预定振荡器的振荡频率和相位差来估计大气压力。

公开(公告)号：US20120036899A1

公开(公告)日：2012-02-16

申请号：US13318325

申请日：2010-06-15

申请人： Shigeaki Seno ,  Akira Kudo

发明人： Shigeaki Seno ,  Akira Kudo

IPC分类号： D04B1/22

CPC分类号： D01F8/16 ,  C08G18/0895 ,  C08G18/10 ,  C08G18/4238 ,  C08G18/4854 ,  C08G18/7671 ,  C08L75/04 ,  D01D5/34 ,  D01F8/12 ,  D01F8/14 ,  C08G18/3206

摘要： Provided is a novel conjugated yarn which: has excellent stretchability; is provided with a sufficient strength; shows high transparency; provides a good tactile sense; and has moderate fit power. Also provided are a knitted fabric knitted by using such conjugated yarn and a clothing product using such knitted fabric. Also provided is a method of producing a novel conjugated yarn which: has excellent stretchability; is provided with a sufficient strength; shows high transparency; provides a good tactile sense; and has moderate fit power. A core-sheath type conjugated yarn of the present invention is a core-sheath type conjugated yarn, including: a core portion containing a polyurethane; and a sheath portion containing an elastomer, in which: the polyurethane includes a double-prepolymer type polyurethane obtained by causing a prepolymer having isocyanate groups at both terminals, which is obtained by causing a polyol and a diisocyanate to react with each other, and a prepolymer having hydroxyl groups at both terminals, which is obtained by causing a polyol, a diisocyanate, and a low-molecular weight diol to react with one another, to react with each other; and the core-sheath type conjugated yarn is obtained by conjugate spinning under conditions of a fineness of 18 to 110 dtex, a weight ratio of the core portion to the sheath portion of 95/5 to 60/40, and a drawing ratio of 1.5 to 4.0.

摘要翻译： 提供了一种新颖的共轭纱线，其具有优异的拉伸性; 具有足够的强度; 透明度高 提供良好的触觉; 并具有适度的适应力。 还提供了使用这种共轭纱线编织的针织物和使用这种针织物的服装产品。 还提供了一种制备具有优异的拉伸性的新型共轭纱的方法; 具有足够的强度; 透明度高 提供良好的触觉; 并具有适度的适应力。 本发明的芯鞘型复合纱是芯鞘型复合纱，包括：含有聚氨酯的芯部; 以及含有弹性体的鞘部，其中：所述聚氨酯包括通过使多元醇和二异氰酸酯相互反应而得到的通过使两端具有异氰酸酯基的预聚物得到的双重预聚型聚氨酯， 通过使多元醇，二异氰酸酯和低分子量二醇相互反应而获得的两端具有羟基的预聚物彼此反应; 并且芯鞘型复合纱通过共轭纺丝在细度为18〜110dtex，芯部与鞘部的重量比为95/5〜60/40的条件下得到，拉伸比为1.5 到4.0。

公开(公告)号：US07300373B2

公开(公告)日：2007-11-27

申请号：US10811848

申请日：2004-03-30

申请人： Makoto Jinno ,  Toyomi Miyagawa ,  Shiro Tsukada ,  Akira Kudo

发明人： Makoto Jinno ,  Toyomi Miyagawa ,  Shiro Tsukada ,  Akira Kudo

IPC分类号： F16H7/06

CPC分类号： F16H7/04 ,  A61B17/0469 ,  A61B34/30 ,  A61B34/70 ,  A61B34/71 ,  A61B2017/00371 ,  A61B2017/00398 ,  A61B2017/2902 ,  A61B2017/292 ,  A61B2017/2927 ,  A61B2017/2929 ,  A61B2017/2932 ,  A61B2017/294 ,  A61B2034/305 ,  A61B2034/715 ,  B25J9/104

摘要： A power transmission mechanism comprising: a flexible power transmission element; a pair of a drive pulley and a driven pulley on which the flexible power transmission element is wound, each the pulley having a pin-embedding hole formed to extend from the outer circumferential thereof toward the center thereof, and a slit elongated in the circumferential direction of the pulley to extend to opposite sides of the embedding hole and communicating with the embedding hole; and a pair of columnar or tapered anchor pins each having a path hole penetrating the anchor pin across the lengthwise direction thereof to receive the flexible power transmission element inserted therein, wherein each the anchor pin receiving the flexible power transmission element in the path hole thereof is embedded in the embedding hole of the associated pulley under pressure, and the flexible power transmission element is thereby held on the pulley.

摘要翻译： 一种动力传递机构，包括：柔性动力传递元件; 一对驱动滑轮和从动皮带轮，其上缠绕有柔性动力传递元件，每个滑轮具有形成为从其外周向其中心延伸的销嵌入孔，以及沿圆周方向延伸的狭缝 所述滑轮延伸到所述嵌入孔的相对侧并与所述嵌入孔连通; 以及一对柱形或锥形的锚定销，每个销钉具有穿过锚定销横跨其长度方向的通路孔，以容纳插入其中的柔性动力传递元件，其中在其路径孔中容纳柔性动力传递元件的每个锚定销是 嵌入在相关皮带轮的嵌入孔中的压力下，由此将柔性动力传递元件保持在皮带轮上。

公开(公告)号：US20070088783A1

公开(公告)日：2007-04-19

申请号：US11606942

申请日：2006-12-01

申请人： Akira Kudo ,  Haruko Sota

发明人： Akira Kudo ,  Haruko Sota

IPC分类号： G06F15/16

CPC分类号： G06F9/54

摘要： The present invention relates to a collaboration apparatus between information processing systems for allowing a plurality of information processing systems to collaborate with each other without awareness of the difference in architecture, and an integrated information processing system in which a plurality of information processing systems are combined by using such a collaboration apparatus between information processing systems. In the case of allowing an SFA system (30) to collaborate with an ERP system (10) in the integrated information processing system including a plurality of information systems, an intersystem collaboration object (40) of the collaboration apparatus between information processing systems generates an active role (51) corresponding to a system of a collaboration origin and a passive rule (52) corresponding to a system of a collaboration target, generates a relating object (53) between these roles in accordance with collaboration information defining a communication method between information systems, and transmits a transaction between the active role (51) and the passive role (52).

摘要翻译： 本发明涉及一种信息处理系统之间的协作装置，用于允许多个信息处理系统彼此协作而不意识到架构差异;以及综合信息处理系统，其中多个信息处理系统由 在信息处理系统之间使用这种协作装置。 在允许SFA系统（30）在包括多个信息系统的综合信息处理系统中与ERP系统（10）协作的情况下，信息处理系统之间的协作装置的系统间协作对象（40）生成 与协作源的系统相对应的活动角色（51）和对应于协作目标的系统的被动规则（52），根据定义信息之间的通信方法的协作信息，在这些角色之间生成相关对象（53） 系统，并在活动角色（51）和被动角色（52）之间传递交易。

公开(公告)号：US06346680B1

公开(公告)日：2002-02-12

申请号：US09576965

申请日：2000-05-24

申请人： Atsushi Takahashi ,  Akira Kudo

发明人： Atsushi Takahashi ,  Akira Kudo

IPC分类号： G01G1900

CPC分类号： G01G21/23 ,  G01B7/287 ,  G01B7/32 ,  G01D5/2417

摘要： A weight and form sensing apparatus according to the present invention provides weight sensors on a base, in matrix pattern for instance. Each weight sensor has a load receiving portion on a top. Weight and form can be sensed by single weight and form sensing apparatus according to the present invention. That is, output values of the weight sensors are summed, so that an article put on the weight sensors can be detected. Also, the existence of the load on each weight sensor is determined based on output signal of each weight sensor, so that the bottom form and size of the article can be identified. The weight and form sensing apparatus according to the present invention can be preferably arranged into a feeding stream of the article because an arrangement of the sensors for identifying the form and size of the article does not interfere an arrangement of the feeding mechanism for the article.

摘要翻译： 根据本发明的重量和形式感测装置在基座上提供例如矩阵图案中的重量传感器。 每个重量传感器在顶部具有负载接收部分。 重量和形状可以通过根据本发明的单个重量和形式感测装置来感测。 也就是说，将重量传感器的输出值相加，从而可以检测放置在重量传感器上的物品。 另外，基于每个重量传感器的输出信号确定每个重量传感器上的负载的存在，从而可以识别物品的底部形状和尺寸。 根据本发明的重量和形状感测装置可以优选地布置成物品的进料流，因为用于识别物品的形状和尺寸的传感器的布置不会干扰物品的进给机构的布置。

公开(公告)号：US5182205A

公开(公告)日：1993-01-26

申请号：US701328

申请日：1991-05-08

申请人： Steven R. Bauer ,  Akira Kudo ,  Georg F. Melchers ,  Nobuo Sakaguchi

发明人： Steven R. Bauer ,  Akira Kudo ,  Georg F. Melchers ,  Nobuo Sakaguchi

IPC分类号： C07K14/47 ,  C12N15/11 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6876 ,  C07K14/47 ,  C12N15/11 ,  C12Q1/6886 ,  G01N33/574 ,  C12Q2600/112 ,  C12Q2600/158

摘要： The present invention provides nucleotide sequences which are selectively expressed in pre-B cells, probes comprising a polynucleotide hybridizing specifically to such a nucleotide sequence and methods for the production of such probes. These probes may be used for identifying pre-B cells. The invention further provides polypeptides translated from a transcript comprising a nucleotide sequence which is selectively expressed in pre-B cells or parts thereof, antibodies against these polypeptides and methods for the preparation and use of the polypeptides and antibodies raised against them.

摘要翻译： 本发明提供在前B细胞中选择性表达的核苷酸序列，包含与这种核苷酸序列特异性杂交的多核苷酸的探针和用于产生这种探针的方法。 这些探针可用于鉴定B细胞。 本发明进一步提供从转录本翻译的多肽，所述转录物包含在前B细胞或其部分选择性表达的核苷酸序列，针对这些多肽的抗体以及用于制备和使用针对它们产生的多肽和抗体的方法。

公开(公告)号：US08333694B2

公开(公告)日：2012-12-18

申请号：US13084119

申请日：2011-04-11

申请人： Akira Kudo ,  Takeshi Oue

发明人： Akira Kudo ,  Takeshi Oue

IPC分类号： A61B1/06 ,  A61B3/00

CPC分类号： A61B1/0676 ,  A61B1/0684 ,  A61B1/128 ,  G02B23/2461

摘要： An illumination unit includes a distal end frame member having a through opening, a plurality of illumination sections, and a holding member which is arranged in the through opening and holds the illumination sections to incline the illumination sections at a desired angle with respect an opening surface of the through opening and to form a cascade along the axial direction of the through opening. The illumination unit includes a reflective member which is configured to reflect the illumination light emitted from the illumination sections toward the opening surface, the reflective member being held by the holding member to face the illumination sections and to apply the illumination light externally emitted from the illumination sections from the inside of the through opening via the opening surface.

摘要翻译： 照明单元包括具有通孔的多个前端框架构件，多个照明区域和保持构件，所述保持构件布置在所述通孔中，并且保持所述照明部分使所述照明部分相对于开口表面以期望的角度倾斜 并且沿着通孔的轴向形成一个级联。 照明单元包括反射构件，其被配置为将从照明区域发射的照明光朝向开口表面反射，反射构件被保持构件保持以面对照明区域并且施加从照明部分外部发射的照明光 通过开口表面从通孔的内部截取。

公开(公告)号：US20110130335A1

公开(公告)日：2011-06-02

申请号：US13054782

申请日：2008-12-15

申请人： Akira Kudo

发明人： Akira Kudo

IPC分类号： A61K38/16 ,  C12Q1/68 ,  C12Q1/02 ,  G01N33/566 ,  A61K31/7088 ,  C07K14/435 ,  C07K16/18 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  A61K48/005 ,  C07K14/47 ,  C12N2799/022 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2500/10 ,  G01N2800/324

摘要： Disclosed are a medicament for treating or preventing diseases with myocardial necrosis, which contains, as an active ingredient, a periostin variant (ΔbΔe) polypeptide or a modified form thereof or a polynucleotide encoding the same; and a diagnostic agent for diseases with myocardial necrosis containing a DNA encoding a periostin variant (ΔbΔe) polypeptide or a partial fragment thereof or an antibody which specifically recognizes a periostin variant (ΔbΔe) polypeptide.

摘要翻译： 公开了用于治疗或预防具有心肌坏死的疾病的药物，其包含作为活性成分的骨膜素变体（＆Dgr; b＆Dgr; e）多肽或其修饰形式或编码其的多核苷酸; 以及含有编码骨膜素变体（＆Dgr; b＆Dgr; e）多肽或其部分片段或特异性识别骨膜素变体（＆Dgr; b＆Dgr; e）多肽的抗体的DNA的具有心肌坏死的疾病的诊断剂。