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1.发明授权公开(公告)号：US07985877B2
公开(公告)日：2011-07-26
申请号：US12301543
申请日：2007-05-31
IPC分类号： C07C59/135 , C07C41/18 , C07C41/22 , C07C43/12 , C07C51/09 , C07C51/367
CPC分类号： C07C41/18 , C07C41/22 , C07C51/09 , C07C51/367 , C07C67/31 , C07C43/12 , C07C69/708
摘要： The present invention provides a process for producing 1,1,1,3,3,3-hexafluoro-2-methoxypropane, wherein a novel compound, 2-methoxy-2-trifluoromethyl-3,3,3-trifluoropropionic acid or a salt thereof is decarboxylated, or wherein an olefin compound represented by chemical formula (4): CF2═C(CF3)(OCH3) is reacted with a fluorinating agent; and a process for producing 2-methoxy-2-trifluoromethyl-3,3,3-trifluoropropionic acid or a salt thereof by reacting a hydroxycarboxylic ester with a methylating agent and then hydrolyzing the reaction product, or hydrolyzing the hydroxycarboxylic ester and then reacting the resulting product with a methylating agent.In accordance with the invention, 1,1,1,3,3,3-hexafluoro-2-methoxypropane, which is useful as a raw material for, for example, the anesthetic Sevoflurane, can be produced efficiently and at low cost.
摘要翻译： 本发明提供一种生产1,1,1,3,3,3-六氟-2-甲氧基丙烷的方法，其中新化合物2-甲氧基-2-三氟甲基-3,3,3-三氟丙酸或其盐 或其中由化学式（4）表示的烯烃化合物：CF 2 = C（CF 3）（OCH 3）与氟化剂反应; 以及通过使羟基羧酸酯与甲基化剂反应然后水解反应产物或水解羟基羧酸酯，然后使所述羟基羧酸酯水解，从而使2-甲氧基-2-三氟甲基-3,3,3-三氟丙酸或其盐 得到的产物与甲基化剂。 根据本发明，作为例如麻醉剂七氟醚的原料可以使用的1,1,1,3,3,3-六氟-2-甲氧基丙烷可以有效且低成本地制造。
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2.发明申请NOVEL CARBOXYLIC ACID COMPOUND, USE THEREOF, AND PROCESS FOR PRODUCING THE SAME 有权新型羧酸化合物，其用途及其生产方法公开(公告)号：US20090156861A1
公开(公告)日：2009-06-18
申请号：US12301543
申请日：2007-05-31
IPC分类号： C07C59/135 , C07C43/12
CPC分类号： C07C41/18 , C07C41/22 , C07C51/09 , C07C51/367 , C07C67/31 , C07C43/12 , C07C69/708
摘要： The present invention provides a process for producing 1,1,1,3,3,3-hexafluoro-2-methoxypropane, wherein a novel compound, 2-methoxy-2-trifluoromethyl-3,3,3-trifluoropropionic acid or a salt thereof is decarboxylated, or wherein an olefin compound represented by chemical formula (4): CF2═C(CF3)(OCH3) is reacted with a fluorinating agent; and a process for producing 2-methoxy-2-trifluoromethyl-3,3,3-trifluoropropionic acid or a salt thereof by reacting a hydroxycarboxylic ester with a methylating agent and then hydrolyzing the reaction product, or hydrolyzing the hydroxycarboxylic ester and then reacting the resulting product with a methylating agent.In accordance with the invention, 1,1,1,3,3,3-hexafluoro-2-methoxypropane, which is useful as a raw material for, for example, the anesthetic Sevoflurane, can be produced efficiently and at low cost.
摘要翻译： 本发明提供一种生产1,1,1,3,3,3-六氟-2-甲氧基丙烷的方法，其中新化合物2-甲氧基-2-三氟甲基-3,3,3-三氟丙酸或其盐 或其中由化学式（4）表示的烯烃化合物：CF 2 -C（CF 3）（OCH 3）与氟化剂反应; 以及通过使羟基羧酸酯与甲基化剂反应然后水解反应产物或水解羟基羧酸酯，然后使所述羟基羧酸酯水解，从而使2-甲氧基-2-三氟甲基-3,3,3-三氟丙酸或其盐 得到的产物与甲基化剂。 根据本发明，作为例如麻醉剂七氟醚的原料可以使用的1,1,1,3,3,3-六氟-2-甲氧基丙烷可以有效且低成本地制造。
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公开(公告)号：US07598425B2
公开(公告)日：2009-10-06
申请号：US11578523
申请日：2005-04-08
IPC分类号： C07C29/48
CPC分类号： C07C29/48 , C07C29/00 , C07C45/30 , C07C31/42 , C07C49/167
摘要： The present invention relates to a method for producing a compound represented by formula (2): [CF3(CF2)n][CF3(CF2)m]C(OH)2 (2) wherein n and m independently represent 0 to 10, the method comprising reacting with a halogen or a halogen-containing oxidizing agent a salt of a compound represented by formula (1): [CF3(CF2)n][CF3(CF2)m]C(OH)COOH (1) wherein n and m independently represent 0 to 10.
摘要翻译： 本发明涉及一种制备式（2）表示的化合物的方法：<？in-line-formula description =“In-line formula”end =“lead”？> [CF3（CF2）n] [CF3（ CF 2）m] C（OH）2（2）<？在线公式描述=“在线公式”end =“tail”？>其中n和m独立地表示0至10，该方法包括与 卤素或含卤素的氧化剂，由式（1）表示的化合物的盐：<？in-line-formula description =“In-line formula”end =“lead”？> [CF3（CF2）n] [ CF 3（CF 2）m] C（OH）COOH（1）<？在线公式描述=“内联式”末端=“尾”→其中n和m独立地表示0至10。
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公开(公告)号：US20080262273A1
公开(公告)日：2008-10-23
申请号：US11578523
申请日：2005-04-08
IPC分类号： C07C31/38
CPC分类号： C07C29/48 , C07C29/00 , C07C45/30 , C07C31/42 , C07C49/167
摘要： The present invention relates to a method for producing a compound represented by formula (2): [CF3(CF2)n][CF3(CF2)m]C(OH)2 (2) wherein n and m independently represent 0 to 10, the method comprising reacting with a halogen or a halogen-containing oxidizing agent a salt of a compound represented by formula (1): [CF3(CF2)n][CF3(CF2)m]C(OH)COOH (1) wherein n and m independently represent 0 to 10.
摘要翻译： 本发明涉及一种制备式（2）表示的化合物的方法：<？in-line-formula description =“In-line formula”end =“lead”？> [CF 3 （CF 2）n [CF 3]（CF 2 2）m] C（OH）2（2）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中n和m独立地表示0至10，该方法包括 与卤素或含卤素的氧化剂与式（1）表示的化合物的盐反应：<？in-line-formula description =“In-line formula”end =“lead”？> [CF （CF 2）2（CF 2）n（CF 2）n（CF 2） C（OH）COOH（1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中n和m独立地表示0至10。
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5.发明申请公开(公告)号：US20100234634A1
公开(公告)日：2010-09-16
申请号：US12734606
申请日：2008-11-06
CPC分类号： C07C69/708 , C07C41/18 , C07C67/307 , C07C43/123
摘要： The present invention provides a process for producing a novel compound, i.e., α-chloromethoxycarboxylic acid ester represented by General Formula (1): (CF3)2C(OCH2Cl)COOR, wherein R is a hydrocarbon group which may be substituted with at least one atom selected from the group consisting of halogen, oxygen, nitrogen, and sulfur atoms, comprising reacting an α-methoxycarboxylic acid ester represented by General Formula (2): (CF3)2C(OCH3)COOR, wherein R is as defined above, with molecular chlorine; and a process for producing 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether represented by a chemical formula (CF3)2CH(OCH2F), comprising fluorinating and decarboxylating the α-chloromethoxycarboxylic acid ester.According to the present invention, 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether (sevoflurane), which is known as a compound having an anesthetic property, can be produced efficiently and at a low cost.
摘要翻译： 本发明提供一种新型化合物的制备方法，即由通式（1）表示的α-氯甲氧基羧酸酯：（CF 3）2 C（OCH 2 Cl）COOR，其中R为可被至少一个 包括将由通式（2）表示的α-甲氧基羧酸酯：（CF 3）2 C（OCH 3）COOR（其中R如上所定义）与由卤素，氧，氮和硫原子组成的组中的原子与 分子氯; 以及由化学式（CF 3）2 CH（OCH 2 F）表示的1,1,1,3,3,3-六氟异丙基氟甲基醚的制备方法，其包括使α-氯甲氧基羧酸酯氟化和脱羧。 根据本发明，可以有效且低成本地制备作为具有麻醉性的化合物的1,1,1,3,3,3-六氟异丙基氟甲基醚（七氟烷）。
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公开(公告)号：US08013182B2
公开(公告)日：2011-09-06
申请号：US12734606
申请日：2008-11-06
CPC分类号： C07C69/708 , C07C41/18 , C07C67/307 , C07C43/123
摘要： The present invention provides a process for producing a novel compound, i.e., α-chloromethoxycarboxylic acid ester represented by General Formula (1): (CF3)2C(OCH2Cl)COOR, wherein R is a hydrocarbon group which may be substituted with at least one atom selected from the group consisting of halogen, oxygen, nitrogen, and sulfur atoms, comprising reacting an α-methoxycarboxylic acid ester represented by General Formula (2): (CF3)2C(OCH3)COOR, wherein R is as defined above, with molecular chlorine; and a process for producing 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether represented by a chemical formula (CF3)2CH(OCH2F), comprising fluorinating and decarboxylating the α-chloromethoxycarboxylic acid ester.According to the present invention, 1,1,1,3,3,3-hexafluoroisopropyl fluoromethyl ether (sevoflurane), which is known as a compound having an anesthetic property, can be produced efficiently and at a low cost.
摘要翻译： 本发明提供一种新型化合物的制备方法，即由通式（1）表示的α-氯甲氧基羧酸酯：（CF 3）2 C（OCH 2 Cl）COOR，其中R为可被至少一个 包括将由通式（2）表示的α-甲氧基羧酸酯：（CF 3）2 C（OCH 3）COOR（其中R如上所定义）与由卤素，氧，氮和硫原子组成的组中的原子与 分子氯; 以及由化学式（CF 3）2 CH（OCH 2 F）表示的1,1,1,3,3,3-六氟异丙基氟甲基醚的制备方法，其包括使α-氯甲氧基羧酸酯氟化和脱羧。 根据本发明，可以有效且低成本地制备作为具有麻醉性的化合物的1,1,1,3,3,3-六氟异丙基氟甲基醚（七氟烷）。
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公开(公告)号：US06933413B2
公开(公告)日：2005-08-23
申请号：US10482410
申请日：2002-07-02
CPC分类号： C07C45/58 , C07C49/167
摘要： The present invention provides a process for the preparation of hexafluoroacetone characterized by bringing hexafluoro-1,2-epoxypropane into contact with at least one catalyst selected from the group consisting of titanium oxide catalysts and fluorinated titanium oxide catalysts to isomerize hexafluoro-1,2-epoxypropane; and a process for the preparation of hexafluoroacetone hydrate characterized by absorbing the hexafluoroacetone prepared by the above process into water to produce crude hexafluoroacetone hydrate, neutralizing the crude hexafluoroacetone hydrate with an alkali, and distilling the resulting mixture. According to the invention, high-purity hexafluoroacetone can be obtained by isomerization of hexafluoro-1,2-epoxypropane with little formation of by-products, and substantially acid-free high-purity hexafluoroacetone hydrate can also be obtained.
摘要翻译： 本发明提供一种制备六氟丙酮的方法，其特征在于使六氟-1,2-环氧丙烷与至少一种选自氧化钛催化剂和氟化氧化钛催化剂的催化剂接触，使六氟-1,2-环氧丙烷异构化， 环氧丙烷 以及制备六氟丙酮水合物的方法，其特征在于将通过上述方法制备的六氟丙酮吸收到水中以产生六氟丙酮水合物，用碱中和六氟丙酮水合物，并蒸馏所得混合物。 根据本发明，可以通过异构化六氟-1,2-环氧丙烷得到高纯度六氟丙酮，几乎不形成副产物，并且也可以获得基本上无酸的高纯度六氟丙酮水合物。
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公开(公告)号：US07939210B2
公开(公告)日：2011-05-10
申请号：US10594702
申请日：2005-03-30
CPC分类号： H01M8/0656 , C01B3/22 , C01B2203/0266 , C01B2203/066 , H01M4/926 , H01M8/0668 , H01M2250/20 , Y02T90/32
摘要： An electric automobile includes a fuel cell for power generation by supply of hydrogen and oxidizing agent, a hydrogen generating device for generating a gas containing hydrogen to be supplied to the fuel cell, and a motor driven by electricity generated by the fuel cell. The hydrogen generating device generates gas containing hydrogen by decomposing an organic compound-containing fuel, and includes a proton conductive partition membrane, a fuel electrode provided on one surface of the partition membrane to directly generate the gas containing hydrogen, a device for supplying, to the fuel electrode, water and organic compound-containing fuel capable of producing a proton as a result of electrochemical oxidization which can pass through the partition membrane, an oxidizing electrode provided on the other surface of the partition membrane, a device for supplying the oxidizing agent to the oxidizing electrode, and a device for generating and collecting the gas containing hydrogen.
摘要翻译： 电动汽车包括用于通过供应氢气和氧化剂发电的燃料电池，用于产生供给燃料电池的含氢气体的氢产生装置和由燃料电池产生的电驱动的电动机。 氢发生装置通过分解含有机化合物的燃料来产生含氢气体，并且包括质子传导隔膜，设置在分隔膜的一个表面上的燃料电极，以直接产生含氢气体的装置， 能够通过隔离膜的电化学氧化产生质子的燃料电极，水和含有机化合物的燃料，设置在分隔膜的另一个表面上的氧化电极，用于供给氧化剂的装置 到氧化电极，以及用于产生和收集含氢气体的装置。
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公开(公告)号：US07910252B2
公开(公告)日：2011-03-22
申请号：US10594711
申请日：2005-03-30
CPC分类号： H01M8/0668 , B01J4/008 , C01B3/22 , C01B2203/0266 , C01B2203/066 , H01M8/04216 , H01M8/0656 , H01M2250/20 , Y02E60/328 , Y02T90/32
摘要： A hydrogen supply system includes at least a hydrogen supply device for supplying hydrogen to a hydrogen storing device, and a hydrogen generating device producing hydrogen containing gas to be supplied to the hydrogen supply device. The hydrogen generating device produces the hydrogen containing gas by decomposing a fuel containing an organic compound, and includes a partition membrane, a fuel electrode provided on one surface of the partition membrane for generating hydrogen containing gas, a device for supplying a fuel containing the organic compound and water to the fuel electrode, an oxidizing electrode provided on the other surface of the partition membrane, a device for supplying an oxidizing agent to the oxidizing electrode, and a device for collecting the hydrogen containing gas directly from the fuel electrode.
摘要翻译： 氢供给系统至少包括用于向氢存储装置供给氢的氢供给装置和产生供给氢供给装置的含氢气体的氢生成装置。 氢产生装置通过分解含有有机化合物的燃料来产生含氢气体，并且包括分隔膜，设置在用于产生含氢气体的分隔膜的一个表面上的燃料电极，用于供给含有有机化合物的燃料的装置 化合物和水到燃料电极，设置在分隔膜的另一个表面上的氧化电极，向氧化电极供应氧化剂的装置，以及用于从燃料电极直接收集含氢气体的装置。
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公开(公告)号：US20090123801A1
公开(公告)日：2009-05-14
申请号：US11921471
申请日：2006-06-02
IPC分类号： H01M8/18
CPC分类号： H01M8/04007 , B60L11/1881 , B60L2200/32 , C01B3/323 , C01B2203/0233 , C01B2203/0277 , C01B2203/041 , C01B2203/0475 , C01B2203/066 , C01B2203/1064 , C01B2203/107 , C01B2203/1223 , H01M8/0612 , H01M2250/20 , Y02P30/30 , Y02T90/32 , Y02T90/34
摘要： A hydrogen generating device capable of generating a gas containing hydrogen at a low temperature, as well as a fuel cell power generating device, an electric automobile, a submergible ship and a hydrogen supply system using the hydrogen generating device are provided.A hydrogen generating device (10) for generating a gas containing hydrogen by decomposing a fuel containing an organic compound, includes: a partition membrane (11); a fuel electrode (12) provided on one surface of the partition membrane (11); a means for supplying a fuel containing organic compound and water to the fuel electrode (12); an oxidizing electrode (14) provided on the other surface of the partition membrane (11); a means for supplying an oxidizing agent to the oxidizing electrode (14); and a means for generating and collecting the gas containing hydrogen from the fuel electrode, and a region of insufficient oxidizing agent supply is provided on the oxidizing electrode side so that a reaction (C) 6H++6e−→3H2 may occur on the fuel electrode side and a reaction (D) CH3OH+H2O→6H++6e−+CO2 may occur on the oxidizing electrode side. The region of insufficient oxidizing agent supply can be provided by performing masking (14M) on part of the gas diffusion layer of the oxidizing electrode (14). Moreover, by connecting the hydrogen generating device (10) to a fuel cell and connecting a fuel cell power generating device for supplying a gas containing hydrogen generated by the hydrogen generating device (10) to the fuel cell, an electric automobile and a submergible ship incorporating the fuel cell power generating device, and the hydrogen generating device (10) to a hydrogen storage means, a hydrogen supply system can be configured for supplying a gas containing hydrogen generated by the hydrogen generating device (10) to the hydrogen storage means.
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