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公开(公告)号：US06962984B2
公开(公告)日：2005-11-08
申请号：US09730559
申请日：2000-12-07
申请人： Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Kawabata , Satoshi Nakagawa , Tatsunari Nishi , Tetsuro Kuga , Shigemasa Sawada , Masami Takei , Kenji Shibata , Akiko Furuya
发明人： Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Kawabata , Satoshi Nakagawa , Tatsunari Nishi , Tetsuro Kuga , Shigemasa Sawada , Masami Takei , Kenji Shibata , Akiko Furuya
CPC分类号： C12Q1/6809 , A61K48/00 , C07K14/47 , G01N33/6893
摘要： A novel DNA whose expression level fluctuates in leukocytes of IgA nephropathy patients in comparison with leukocytes of healthy persons, a process for isolating the DNA, a novel protein encoded by the DNA, an antibody recognizing the protein, methods for detecting the protein and the DNA, and methods of diagnosis and treatment of IgA nephropathy.
摘要翻译： 与健康人的白细胞相比，IgA肾病患者的白细胞中的表达水平波动的新型DNA，分离DNA的方法，DNA编码的新型蛋白质，识别蛋白质的抗体，检测蛋白质和DNA的方法 ，以及IgA肾病的诊断和治疗方法。
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公开(公告)号：US06790944B1
公开(公告)日：2004-09-14
申请号：US09129603
申请日：1998-08-05
申请人： Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Kawabata , Satoshi Nakagawa , Tetsuro Kuga , Tatsunari Nishi , Nobuo Nomura , Takahiro Nagase , Shigemasa Sawada , Masami Takei
发明人： Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Kawabata , Satoshi Nakagawa , Tetsuro Kuga , Tatsunari Nishi , Nobuo Nomura , Takahiro Nagase , Shigemasa Sawada , Masami Takei
IPC分类号： C07H2102
CPC分类号： C07K14/47
摘要： The present invention relates to a novel protein isolated from the leukocyte of IgA nephropathy patients, and DNA encoding the protein. It also relates to an oligonucleotide based on the nucleotide sequence complementary with the DNA, an antibody which specifically reacts with the protein and, furthermore, diagnostic and therapeutic drugs of IgA nephropathy comprising it.
摘要翻译： 本发明涉及从IgA肾病患者的白细胞分离的新型蛋白质和编码该蛋白质的DNA。 它还涉及基于与DNA互补的核苷酸序列的寡核苷酸，与蛋白特异性反应的抗体，以及包含它的IgA肾病的诊断和治疗药物。
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公开(公告)号：US06828428B2
公开(公告)日：2004-12-07
申请号：US09090672
申请日：1998-06-04
申请人： Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Nishimura , Satoshi Nakagawa , Tatsunari Nishi , Tetsuro Kuga , Shigemasa Sawada , Masami Takei
发明人： Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Nishimura , Satoshi Nakagawa , Tatsunari Nishi , Tetsuro Kuga , Shigemasa Sawada , Masami Takei
IPC分类号： C07H2102
CPC分类号： G01N33/6893 , A61K48/00 , C07K14/47 , C12Q1/6809
摘要： The present invention relates to a novel DNA related to IgA nephropathy obtained by a differential display method [FEBS Letters, 351, 231 (1994)] taking note of an mRNA whose expression level fluctuates in leukocytes of IgA nephropathy patients in comparison with leukocytes of healthy persons, a process for isolating the DNA, a method for detecting the DNA, a novel protein encoded by the DNA, an antibody recognizing the protein, a method for detecting the protein, and diagnosis and treatment of IgA nephropathy.
摘要翻译： 本发明涉及通过差异显示法获得的与IgA肾病有关的新型DNA [FEBS Letters，351,231（1994）]，注意到与IgA肾病患者的白细胞相比，其表达水平波动的mRNA与健康白细胞相比 人，分离DNA的方法，DNA检测方法，由DNA编码的新型蛋白质，识别蛋白质的抗体，检测蛋白质的方法以及诊断和治疗IgA肾病。
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公开(公告)号：US20050187380A1
公开(公告)日：2005-08-25
申请号：US11094718
申请日：2005-03-31
申请人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
IPC分类号： A61P11/06 , A61P17/00 , A61P27/14 , A61P37/08 , C07K16/28 , C12N15/13 , C12P21/08 , G01N33/543 , C07H21/04 , C07K14/28 , C12N5/06
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译： 与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用 重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。
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公开(公告)号：US20100221178A1
公开(公告)日：2010-09-02
申请号：US12684651
申请日：2010-01-08
申请人： Kenya SHITARA , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya SHITARA , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
IPC分类号： A61K39/395 , A61K51/10 , A61P37/00
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译： 与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用 重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。
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公开(公告)号：US07666418B2
公开(公告)日：2010-02-23
申请号：US11094718
申请日：2005-03-31
申请人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译： 与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用 重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。
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公开(公告)号：US06989145B2
公开(公告)日：2006-01-24
申请号：US09796744
申请日：2001-03-02
申请人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译： 与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用 重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。
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公开(公告)号：US08632996B2
公开(公告)日：2014-01-21
申请号：US13492465
申请日：2012-06-08
申请人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
IPC分类号： C12P21/00
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译： 与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用 重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。
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公开(公告)号：US08197814B2
公开(公告)日：2012-06-12
申请号：US12684651
申请日：2010-01-08
申请人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
IPC分类号： A61K39/395
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译： 与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用 重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。
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