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    ASTEXIN PEPTIDES
    3.
    发明申请
    ASTEXIN PEPTIDES 审中-公开

    公开(公告)号：US20150225463A1

    公开(公告)日：2015-08-13

    申请号：US14424617

    申请日：2013-08-29

    申请人： The Trustees of Princeton University

    发明人： A. James Link ,  Mikhail O. Maksimov

    IPC分类号： C07K14/195 ,  C02F1/28 ,  A62D3/33 ,  A01N63/02

    CPC分类号： C07K14/195 ,  A01N63/02 ,  A62D3/33 ,  A62D2101/43 ,  C02F1/286 ,  C02F2101/20

    摘要： Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticaccaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.

    摘要翻译： 提供基于在Asticaccaulis excentricus中鉴定的序列的astexin-1，astexin-2和astexin-3套索肽，以及制备和使用它们的方法。 与许多主要是疏水性的套索肽相比，Astexin-1具有极高的极性，并且对于与白to（Exicaccaulis excentricus）有关的细菌，具有适度的抗菌活性。 确定了Astexin-1的溶液结构，揭示了通过肽段之间的氢键稳定的独特拓扑。 Astexins-2和-3是细胞内衣索肽。

    ASTEXIN PEPTIDES
    4.
    发明申请
    ASTEXIN PEPTIDES 审中-公开

    公开(公告)号：US20190040107A1

    公开(公告)日：2019-02-07

    申请号：US16057292

    申请日：2018-08-07

    申请人： The Trustees of Princeton University

    发明人： A. James Link ,  Mikhail O. Maksimov

    IPC分类号： C07K14/195 ,  A62D3/33 ,  C02F1/28 ,  A01N63/02 ,  C02F101/20 ,  A62D101/43

    摘要： Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticcacaulis excentricus, and methods of making and using same.Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticcacaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.

    ASTEXIN PEPTIDES
    6.
    发明申请
    ASTEXIN PEPTIDES 有权

    公开(公告)号：US20210107950A1

    公开(公告)日：2021-04-15

    申请号：US17128632

    申请日：2020-12-21

    申请人： The Trustees of Princeton University

    发明人： A. James Link ,  Mikhail O. Maksimov

    IPC分类号： C07K14/195 ,  A01N63/10 ,  A62D3/33 ,  C02F1/28

    摘要： Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus, and methods of making and using same.
    Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticaccaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.