公开(公告)号：US20230227512A1

公开(公告)日：2023-07-20

申请号：US17937719

申请日：2022-10-03

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter Kwong ,  Marie Pancera ,  Tongqing Zhou ,  Ivelin Georgiev ,  Michael Gordon Joyce ,  Priyamvada Acharya ,  Jason Gorman ,  Yongping Yang ,  Guillaume Stewart-Jones ,  Rita Chen ,  Gwo-Yu Chuang ,  John Mascola ,  Baoshan Zhang ,  Cheng Cheng ,  Mallika Sastry ,  Aliaksandr Druz

IPC分类号： C07K14/435 ,  A61K39/12 ,  C07K14/005 ,  A61K39/21 ,  C07K16/10 ,  G01N33/569

CPC分类号： C07K14/435 ,  A61K39/12 ,  C07K14/005 ,  A61K39/21 ,  C07K16/1063 ,  G01N33/56988 ,  C12N2740/16122 ,  C12N2740/16134 ,  A61K2039/55555

摘要： HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

公开(公告)号：US20220064222A1

公开(公告)日：2022-03-03

申请号：US17524380

申请日：2021-11-11

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter Kwong ,  Barney Graham ,  John Mascola ,  Li Ou ,  Aliaksandr Druz ,  Man Chen ,  Wing-Pui Kong ,  Ivelin Stefanov Georgiev ,  Emily Rundlet ,  Michael Gordon Joyce ,  Yaroslav Tsybovsky ,  Paul Thomas ,  Marie Pancera ,  Mallika Sastry ,  Cinque Soto ,  Joseph Van Galen ,  Guillaume Stewart-Jones ,  Yongping Yang ,  Baoshan Zhang ,  Ulrich Baxa

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61P37/04 ,  A61P31/14

摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.

公开(公告)号：US20240101609A1

公开(公告)日：2024-03-28

申请号：US18537448

申请日：2023-12-12

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  Institute for Research in Biomedicine

发明人： Baoshan Zhang ,  Guillaume Stewart-Jones ,  Tongqing Zhou ,  John Mascola ,  Kai Xu ,  Yongping Yang ,  Paul Thomas ,  Gwo-Yu Chuang ,  Li Ou ,  Peter Kwong ,  Yaroslav Tsybovsky ,  Wing-Pui Kong ,  Aliaksandr Druz ,  Davide Corti ,  Antonio Lanzavecchia

IPC分类号： C07K14/005 ,  A61K39/155 ,  A61P31/14 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/155 ,  A61P31/14 ,  C12N7/00 ,  C07K2319/50 ,  C12N2760/18634 ,  C12N2760/18734

摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.

公开(公告)号：US20210198324A1

公开(公告)日：2021-07-01

申请号：US17202231

申请日：2021-03-15

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter Kwong ,  Ivelin Georgiev ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Aliaksandr Druz ,  Ulrich Baxa ,  Joseph Van Galen ,  Cheng Cheng ,  John Mascola ,  Yaroslav Tsybovsky ,  Yongping Yang ,  Barney Graham ,  Syed Mohammad Moin ,  Jeffrey Boyington

IPC分类号： C07K14/11 ,  A61K39/21 ,  C07K14/08 ,  C07K14/16 ,  C07K14/165 ,  C07K14/435 ,  C12N7/00

摘要： Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.