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1.发明申请Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis 审中-公开杀虫病毒化合物和组合物，其药物用途和用于其合成的材料公开(公告)号：US20050101651A1
公开(公告)日：2005-05-12
申请号：US10986109
申请日：2004-11-12
申请人： Theodore Johnson , Ye Hua , Hiep Luu , Peter Dragovich
发明人： Theodore Johnson , Ye Hua , Hiep Luu , Peter Dragovich
IPC分类号： A61K31/4015 , A61K31/4025 , A61K38/00 , A61P31/12 , A61P43/00 , C07D20060101 , C07D207/26 , C07D207/32 , C07D207/333 , C07D207/34 , C07D401/04 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/04 , C07K5/02 , A61K31/4178 , A61K31/4164 , C07D43/02 , A61K31/41
CPC分类号： C07D207/26 , A61K38/00 , C07D207/333 , C07D207/34 , C07D401/04 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/04 , C07K5/0205 , Y02A50/463
摘要： Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picomaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
摘要翻译： 下式的化合物：其中式变数如本公开内容所定义，有利地抑制或阻断微乳蛋白酶3C蛋白酶的生物学活性。 这些化合物以及含有这些化合物的药物组合物可用于治疗感染了一种或多种皮瘤病毒如RVP的患者或宿主。 还描述了制备这些化合物的中间体和合成方法。
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2.发明申请Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis 失效杀虫病毒化合物和组合物，其药物用途和用于其合成的材料公开(公告)号：US20050080121A1
公开(公告)日：2005-04-14
申请号：US10626827
申请日：2003-07-23
申请人： Ye Hua , Hiep Luu , Fora Chan , Theodore Johnson , Siegfried Reich , Donald Skalitsky , Yi Yang , Thomas Hendrickson , Shao Chu , Brian Eastman
发明人： Ye Hua , Hiep Luu , Fora Chan , Theodore Johnson , Siegfried Reich , Donald Skalitsky , Yi Yang , Thomas Hendrickson , Shao Chu , Brian Eastman
IPC分类号： A61K31/216 , A61K31/235 , A61K31/381 , A61K31/4015 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/4192 , A61K31/427 , A61K31/4439 , A61K31/47 , A61K31/498 , A61P31/14 , A61P43/00 , C07C233/85 , C07C237/22 , C07C237/36 , C07C275/16 , C07D207/26 , C07D209/42 , C07D215/48 , C07D231/14 , C07D241/44 , C07D249/06 , C07D333/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , A61K31/4196 , A61K31/4025 , A61K31/4178 , C07D43/02
CPC分类号： C07D207/26 , C07C237/22 , C07C275/16 , C07D209/42 , C07D215/48 , C07D231/14 , C07D241/44 , C07D249/06 , C07D333/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12
摘要： Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
摘要翻译： 下式的化合物：其中式变数如本公开内容所定义，有利地抑制或阻断微乳蛋白酶3C蛋白酶的生物学活性。 这些化合物以及含有这些化合物的药物组合物可用于治疗感染一种或多种微小核糖核酸病毒如RVP的患者或宿主。 还描述了制备这些化合物的中间体和合成方法。
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公开(公告)号：US06534524B1
公开(公告)日：2003-03-18
申请号：US09983783
申请日：2001-10-25
申请人： Robert Steven Kania , Steven Lee Bender , Allen J. Borchardt , Stephan James Cripps , Ye Hua , Michael David Johnson , Theodore Otto Johnson, Jr. , Hiep The Luu , Cynthia Louise Palmer , Siegfried Heinz Reich , Anna Marie Tempczyk-Russell , Min Teng , Christine Thomas , Michael David Varney , Michael Brennan Wallace , Michael Raymond Collins
发明人： Robert Steven Kania , Steven Lee Bender , Allen J. Borchardt , Stephan James Cripps , Ye Hua , Michael David Johnson , Theodore Otto Johnson, Jr. , Hiep The Luu , Cynthia Louise Palmer , Siegfried Heinz Reich , Anna Marie Tempczyk-Russell , Min Teng , Christine Thomas , Michael David Varney , Michael Brennan Wallace , Michael Raymond Collins
IPC分类号： C07D40302
CPC分类号： C07D401/12 , C07D209/18 , C07D401/14 , C07D403/12
摘要： Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
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4.发明授权Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use 有权吲唑化合物和抑制蛋白激酶的药物组合物及其使用方法公开(公告)号：US06884890B2
公开(公告)日：2005-04-26
申请号：US10326755
申请日：2003-02-13
申请人： Robert Steven Kania , Steven Lee Bender , Allen J. Borchardt , Stephan James Cripps , Ye Hua , Michael David Johnson , Theodore Otto Johnson, Jr. , Hiep The Luu , Cynthia Louise Palmer , Siegfried Heinz Reich , Anna Marie Tempczyk-Russell , Min Teng , Christine Thomas , Michael David Varney , Michael Brennan Wallace , Michael Raymond Collins
发明人： Robert Steven Kania , Steven Lee Bender , Allen J. Borchardt , Stephan James Cripps , Ye Hua , Michael David Johnson , Theodore Otto Johnson, Jr. , Hiep The Luu , Cynthia Louise Palmer , Siegfried Heinz Reich , Anna Marie Tempczyk-Russell , Min Teng , Christine Thomas , Michael David Varney , Michael Brennan Wallace , Michael Raymond Collins
IPC分类号： C07D209/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D401/02
CPC分类号： C07D401/12 , C07D209/18 , C07D401/14 , C07D403/12
摘要： Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要翻译： 描述了调节和/或抑制某些蛋白激酶活性的吲唑化合物。 这些化合物和含有它们的药物组合物能够介导酪氨酸激酶信号转导，从而调节和/或抑制不期望的细胞增殖。 本发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及治疗与不需要的血管生成和/或细胞增殖相关的癌症和其它疾病状态的方法，例如糖尿病性视网膜病变，新生血管性青光眼，类风湿性关节炎和 银屑病，通过施用有效量的这种化合物。
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5.发明授权Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis 失效杀虫病毒化合物和组合物，其药物用途和用于其合成的材料公开(公告)号：US06872745B2
公开(公告)日：2005-03-29
申请号：US10435082
申请日：2003-05-12
IPC分类号： A61K31/4015 , A61K31/4025 , A61K38/00 , A61P31/12 , A61P43/00 , C07D20060101 , C07D207/26 , C07D207/32 , C07D207/333 , C07D207/34 , C07D401/04 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/04 , C07K5/02 , C07D207/04
CPC分类号： C07D207/26 , A61K38/00 , C07D207/333 , C07D207/34 , C07D401/04 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/04 , C07K5/0205 , Y02A50/463
摘要： Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
摘要翻译： 下式的化合物：其中式变量如本公开所定义，有利地抑制或阻断小核糖核蛋白病毒3C蛋白酶的生物学活性。 这些化合物以及含有这些化合物的药物组合物可用于治疗感染一种或多种微小核糖核酸病毒如RVP的患者或宿主。 还描述了制备这些化合物的中间体和合成方法。
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6.发明授权Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use 有权用于抑制蛋白激酶的吲唑化合物和药物组合物及其使用方法公开(公告)号：US06891044B2
公开(公告)日：2005-05-10
申请号：US10326037
申请日：2003-02-15
申请人： Robert Steven Kania , Steven Lee Bender , Allen J. Borchardt , Stephan James Cripps , Ye Hua , Michael David Johnson , Theodore Otto Johnson, Jr. , Hiep The Luu , Cynthia Louise Palmer , Siegfried Heinz Reich , Anna Maria Tempczyk-Russell , Min Teng , Christine Thomas , Michael David Varney , Michael Brennan Wallace , Michael Raymond Collins
发明人： Robert Steven Kania , Steven Lee Bender , Allen J. Borchardt , Stephan James Cripps , Ye Hua , Michael David Johnson , Theodore Otto Johnson, Jr. , Hiep The Luu , Cynthia Louise Palmer , Siegfried Heinz Reich , Anna Maria Tempczyk-Russell , Min Teng , Christine Thomas , Michael David Varney , Michael Brennan Wallace , Michael Raymond Collins
IPC分类号： C07D209/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D401/02
CPC分类号： C07D401/12 , C07D209/18 , C07D401/14 , C07D403/12
摘要： Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要翻译： 描述了调节和/或抑制某些蛋白激酶活性的吲唑化合物。 这些化合物和含有它们的药物组合物能够介导酪氨酸激酶信号转导，从而调节和/或抑制不期望的细胞增殖。 本发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及治疗与不需要的血管生成和/或细胞增殖相关的癌症和其它疾病状态的方法，例如糖尿病性视网膜病变，新生血管性青光眼，类风湿性关节炎和 银屑病，通过施用有效量的这种化合物。
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7.发明授权Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis 失效杀虫病毒化合物和组合物，其药物用途和用于其合成的材料公开(公告)号：US06632825B2
公开(公告)日：2003-10-14
申请号：US09882345
申请日：2001-06-13
申请人： Theodore O. Johnson, Jr. , Shao Song Chu , Brian Walter Eastman , Ye Hua , Hiep The Luu , Siegfried Heinz Reich , Donald James Skalitzky , Yi Yang , Thomas F. Hendrickson , Fora P. Chan
发明人： Theodore O. Johnson, Jr. , Shao Song Chu , Brian Walter Eastman , Ye Hua , Hiep The Luu , Siegfried Heinz Reich , Donald James Skalitzky , Yi Yang , Thomas F. Hendrickson , Fora P. Chan
IPC分类号： A61K3144
CPC分类号： C07D207/26 , C07C237/22 , C07C275/16 , C07D209/42 , C07D215/48 , C07D231/14 , C07D241/44 , C07D249/06 , C07D333/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12
摘要： Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
摘要翻译： 下式的化合物：其中式变量如本公开所定义，有利地抑制或阻断小核糖核蛋白病毒3C蛋白酶的生物学活性。 这些化合物以及含有这些化合物的药物组合物可用于治疗感染一种或多种微小核糖核酸病毒如RVP的患者或宿主。 还描述了制备这些化合物的中间体和合成方法
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公开(公告)号：US08505094B1
公开(公告)日：2013-08-06
申请号：US12686458
申请日：2010-01-13
申请人： Zhu Xuewen , Wan Xinochuan , Ye Hua
发明人： Zhu Xuewen , Wan Xinochuan , Ye Hua
IPC分类号： G06F21/00 , G06F11/00 , G06F12/16 , G06F15/16 , G06F15/173 , G06F17/30 , G06F13/00 , H04L29/06
CPC分类号： H04L67/2819 , G06F21/566 , G06F2221/2119 , H04L63/1416 , H04L63/168 , H04L67/02
摘要： Detection of malicious URLs in a Web page retrieved by a computer user is based in a backend security service or upon the user's computer. The HTML code download by the user is first scanned to detect any embedded links such as URLs found in frames or scripts. Features related to the layout of such a URL (position, visibility) are identified. Features related to the referring nature of the URL (page rank of parent, page rank of child) are identified. Features indicating the relevancy between the content of the parent Web page and the content of the Web page identified by the embedded URL identified. Each set of features is transformed into a binary vector and these vectors are fed into a decision engine such as a classifier algorithm. The classifier algorithm outputs a score indicating whether or not the suspect URL (and the Web page to which it links) is malicious or not. The user may be warned by a display message.
摘要翻译： 由计算机用户检索的网页中的恶意URL的检测基于后端安全服务或用户的计算机。 首先扫描用户下载的HTML代码，以检测任何嵌入的链接，例如在帧或脚本中找到的URL。 识别与这样的URL（位置，可见性）的布局相关的特征。 识别与URL的参考性质相关的特征（父级的页面排名，小孩的页面排名）。 表明父网页的内容与所识别的嵌入式网页所标识的网页的内容之间的相关性。 每组特征被转换成二进制向量，并且这些向量被馈送到诸如分类器算法的决策引擎中。 分类器算法输出一个分数，表示可疑URL（和链接到的网页）是否是恶意的。 用户可能会受到显示消息的警告。
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公开(公告)号：US07141587B2
公开(公告)日：2006-11-28
申请号：US10992146
申请日：2004-11-18
申请人： Robert Steven Kania , Steven Lee Bender , Allen J. Borchardt , Stephan James Cripps , Ye Hua , Michael David Johnson , Theodore Otto Johnson, Jr. , Hiep The Luu , Cynthia Louise Palmer , Siegfried Heinz Reich , Anna Maria Tempczyk-Russell , Min Teng , Christine Thomas , Michael David Varney , Michael Brennan Wallace , Michael Raymond Collins
发明人： Robert Steven Kania , Steven Lee Bender , Allen J. Borchardt , Stephan James Cripps , Ye Hua , Michael David Johnson , Theodore Otto Johnson, Jr. , Hiep The Luu , Cynthia Louise Palmer , Siegfried Heinz Reich , Anna Maria Tempczyk-Russell , Min Teng , Christine Thomas , Michael David Varney , Michael Brennan Wallace , Michael Raymond Collins
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D401/12 , C07D209/18 , C07D401/14 , C07D403/12
摘要： Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
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10.发明授权Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis 失效杀虫病毒化合物和组合物，其药物用途和用于其合成的材料公开(公告)号：US06989384B2
公开(公告)日：2006-01-24
申请号：US10626827
申请日：2003-07-23
申请人： Ye Hua , Hiep The Luu , Fora P. Chan , Theodore O. Johnson, Jr. , Siegfried Heinz Reich , Donald James Skalitzky , Yi Yang , Thomas F. Hendrickson , Shao Song Chu , Brian Walter Eastman
发明人： Ye Hua , Hiep The Luu , Fora P. Chan , Theodore O. Johnson, Jr. , Siegfried Heinz Reich , Donald James Skalitzky , Yi Yang , Thomas F. Hendrickson , Shao Song Chu , Brian Walter Eastman
IPC分类号： A61K31/40 , A61K31/4439 , C07D207/12 , C07D401/02 , C07D403/02
CPC分类号： C07D207/26 , C07C237/22 , C07C275/16 , C07D209/42 , C07D215/48 , C07D231/14 , C07D241/44 , C07D249/06 , C07D333/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12
摘要： Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
摘要翻译： 下式的化合物：其中式变数如本公开内容所定义，有利地抑制或阻断微乳蛋白酶3C蛋白酶的生物学活性。 这些化合物以及含有这些化合物的药物组合物可用于治疗感染一种或多种微小核糖核酸病毒如RVP的患者或宿主。 还描述了制备这些化合物的中间体和合成方法。
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