摘要:
Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
摘要:
Aromatic diamide derivative represented by the general formula (I) or a salt thereof and agricultural/herticultural composition containing the same as the active ingredient, wherein A1 represents alkylene, alkenylene or alkynylene; B represents, CO— or —C(═N—OR4)— (wherein R4 represents H, etc.); R1 to R3 represent each H, etc.; Q1 to Q5 represent each N or carbon; Y represents halogeno, etc.; m is from 0 to 5; and Z1 and Z2 represent each O or S.
摘要翻译:由通式(I)表示的芳族二酰胺衍生物或其盐和含有与活性成分相同的农业/农业组合物,其中A 1表示亚烷基,亚烯基或亚炔基; B表示CO-或-C(= N-OR 4) - (其中R 4表示H等); R 1至R 3代表每个H等; Q 1至Q 5代表每个N或碳; Y代表卤素等; m为0〜5; Z 1和Z 2代表O或S.
摘要:
Enamides are prepared by hydrogenating oximes having at least one hydrogen atom at the .alpha.-position in the presence of a carboxylic anhydride using a ruthenium catalyst. These enamides are important to obtain amino group-containing compounds by reduction or polymerization.
摘要:
Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed.
摘要:
The present invention relates to the use of dehydroalanine derivatives of formula (I) ##STR1## with R.sub.1 : H or linear- or branched-chain C.sub.1 C.sub.4 alkyl, ##STR2## or linear- or branched-chain C.sub.1 -C.sub.20 alkyl where X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5 =H, halogen, hydroxyl, linear-or branched-chain C.sub.1 -C.sub.4 alkyl or alkoxy, ##STR3## and n=2, 3 or 4, for protecting the skin, the mucous membranes and/or the hair against oxidative stress and to the cosmetic and dermatological compositions containing such compounds and to new dehydroalanine derivatives.