公开(公告)号：US20050288654A1

公开(公告)日：2005-12-29

申请号：US11146302

申请日：2005-06-06

申请人： Tim Nieman ,  Ninh Dang ,  Tazi Pruitt ,  Jim Ward ,  Erik Bulman ,  Mathew Williams ,  John Murphy

发明人： Tim Nieman ,  Ninh Dang ,  Tazi Pruitt ,  Jim Ward ,  Erik Bulman ,  Mathew Williams ,  John Murphy

IPC分类号： A61B17/00 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  A61B18/22

CPC分类号： A61B18/22 ,  A61B18/14 ,  A61B2017/00243 ,  A61B2018/00196 ,  A61B2018/00577 ,  A61B2018/2261 ,  A61B2018/2272

摘要： Ablation instruments and methods are disclosed for ablating diseased tissue such as cardiac tissue. The ablation device can remotely apply ablative energy to biological tissue and comprises a flexible elongate member having a proximal end, a distal end and a longitudinal lumen extending therebetween. An energy emitting element is disposed within the longitudinal lumen of the flexible elongate member. The energy emitting element has a proximal end and a distal end for emitting energy along at least a portion of its length. The device is configured to emit a variable amount of energy along a length of the flexible elongate member. The method includes introducing the flexible elongate member into a predetermined tissue site to ablate a target tissue. The target tissue is ablated, coagulated or photochemically modulated without damaging surrounding tissue.

摘要翻译： 公开消融仪器和方法来消融诸如心脏组织的病变组织。 消融装置可以远程地将烧蚀能量应用于生物组织，并且包括柔性细长构件，其具有在其间延伸的近端，远端和纵向内腔。 能量发射元件设置在柔性细长构件的纵向内腔内。 能量发射元件具有近端和远端，用于沿其长度的至少一部分发射能量。 该装置构造成沿着柔性细长构件的长度发射可变量的能量。 该方法包括将柔性细长构件引入预定的组织部位以烧蚀靶组织。 目标组织被消融，凝固或光化学调节而不损伤周围的组织。

公开(公告)号：US20050273090A1

公开(公告)日：2005-12-08

申请号：US11146313

申请日：2005-06-06

申请人： Tim Nieman ,  Ninh Dang ,  Tazi Pruitt ,  Erik Bulman ,  Mathew Williams ,  Jim Ward ,  John Murphy

发明人： Tim Nieman ,  Ninh Dang ,  Tazi Pruitt ,  Erik Bulman ,  Mathew Williams ,  Jim Ward ,  John Murphy

IPC分类号： A61B17/00 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  A61B18/22

CPC分类号： A61B18/22 ,  A61B18/14 ,  A61B2017/00243 ,  A61B2018/00196 ,  A61B2018/00577 ,  A61B2018/2261 ,  A61B2018/2272

摘要： Ablation instruments and methods are disclosed for ablating diseased tissue such as cardiac tissue. The method includes introducing a flexible elongate member into a predetermined tissue site with a flexible elongate member having a proximal end, a distal end and a longitudinal lumen extending therebetween. A slidable conductor is positioned through the lumen proximate to the tissue site and energy is transmitted to the distal end of the elongate member through the conductor. The flexible elongate member is both longitudinally flexible and resists twisting during bending. The target tissue is ablated, coagulated or photochemically modulated without damaging surrounding tissue.

摘要翻译： 公开消融仪器和方法来消融诸如心脏组织的病变组织。 该方法包括将柔性细长构件引入预定的组织部位，其中柔性细长构件具有近端，远端和在其间延伸的纵向内腔。 可滑动的导体通过内腔定位成靠近组织部位，并且能量通过导体传递到细长构件的远端。 柔性细长构件纵向柔性并且在弯曲期间抵抗扭转。 目标组织被消融，凝固或光化学调节而不损伤周围的组织。

公开(公告)号：US09095681B2

公开(公告)日：2015-08-04

申请号：US12626531

申请日：2009-11-25

申请人： Tal Wenderow ,  Thomas Bromander ,  James J. Kennedy, III ,  Stanley O. Thompson ,  Jon B. Taylor ,  Jeffrey Lightcap ,  John Murphy ,  Graham Eacock

发明人： Tal Wenderow ,  Thomas Bromander ,  James J. Kennedy, III ,  Stanley O. Thompson ,  Jon B. Taylor ,  Jeffrey Lightcap ,  John Murphy ,  Graham Eacock

IPC分类号： A61M25/00 ,  A61B19/00 ,  A61M25/01 ,  A61M25/09 ,  A61B17/00

CPC分类号： A61M25/0147 ,  A61B17/00234 ,  A61B34/30 ,  A61B90/98 ,  A61B2017/00323 ,  A61B2017/00477 ,  A61B2034/301 ,  A61M25/0113 ,  A61M25/09041

摘要： A catheter system including a housing and a first drive mechanism supported by the housing configured to impart movement to a first catheter device is provided. The first drive mechanism is moveable between an engaged position in which the first drive mechanism engages the first catheter device and a disengaged position in which the first drive mechanism does not engage the first catheter device. The catheter system includes a second drive mechanism supported by the housing configured to impart movement to a second catheter device. The second drive mechanism is moveable between an engaged position in which the second drive mechanism engages the second catheter device and a disengaged position in which the second drive mechanism does not engage the second catheter device. The catheter system includes a manual control configured to allow a user to manually move the first drive mechanism and the second drive mechanism between the engaged and disengaged positions. The first drive mechanism and the second drive mechanism are also configured to be moved between the engaged and disengaged positions by an electronic actuator responsive to a user's activation of a control. The first drive mechanism and the second drive mechanism are configured to be moved between the respective engaged and disengaged positions synchronized with each other.

摘要翻译： 提供了一种导管系统，其包括壳体和由所述壳体支撑的第一驱动机构，所述第一驱动机构构造成将移动传递给第一导管装置。 第一驱动机构可在其中第一驱动机构接合第一导管装置的接合位置与第一驱动机构不接合第一导管装置的分离位置之间移动。 导管系统包括由壳体支撑的第二驱动机构，该第二驱动机构构造成将运动传递给第二导管装置。 第二驱动机构可在其中第二驱动机构接合第二导管装置的接合位置与第二驱动机构不接合第二导管装置的分离位置之间移动。 导管系统包括手动控制器，其被配置为允许使用者在接合位置和脱离位置之间手动地移动第一驱动机构和第二驱动机构。 第一驱动机构和第二驱动机构还构造成通过响应于用户对控制的激活的电子执行器在接合位置和脱离位置之间移动。 第一驱动机构和第二驱动机构构造成在彼此同步的相应的接合位置和脱离位置之间移动。

公开(公告)号：US20130231631A1

公开(公告)日：2013-09-05

申请号：US13600824

申请日：2012-08-31

申请人： John Murphy ,  Tal Wenderow ,  David Handler

发明人： John Murphy ,  Tal Wenderow ,  David Handler

IPC分类号： A61M25/01

CPC分类号： A61M25/0105 ,  A61B34/30 ,  A61B2017/00243 ,  A61B2034/301 ,  A61B2090/376 ,  A61M25/0113

摘要： A robotic catheter procedure system for performing a procedure on a patient is provided. The robotic catheter procedure system includes a bedside system and a remote workstation. The bedside system includes a percutaneous device and an actuating mechanism configured to engage and to impart movement to the percutaneous device. The remote workstation includes a user interface configured to receive a user input and a display device configured to display an image of a portion of the patient. The image includes a magnification level. The workstation also includes a control system operatively coupled to the user interface. The control system is configured to generate a control signal. The actuating mechanism causes movement of the percutaneous device in response to the control signal, and the control signal is based upon the user input and the magnification level.

摘要翻译： 提供了一种用于对患者进行手术的机器人导管程序系统。 机器人导管程序系统包括床边系统和远程工作站。 床边系统包括经皮装置和致动机构，其构造成接合和赋予经皮装置的运动。 远程工作站包括被配置为接收用户输入的用户界面和被配置为显示患者的一部分的图像的显示设备。 图像包括放大级别。 工作站还包括可操作地耦合到用户界面的控制系统。 控制系统被配置为产生控制信号。 致动机构响应于控制信号引起经皮装置的移动，并且控制信号基于用户输入和放大级别。

公开(公告)号：USD685468S1

公开(公告)日：2013-07-02

申请号：US29427515

申请日：2012-07-19

申请人： John Murphy ,  Stephen Guerrera ,  Tal Wenderow

设计人： John Murphy ,  Stephen Guerrera ,  Tal Wenderow

CPC分类号： A61M25/0147 ,  A61B17/00234 ,  A61B34/30 ,  A61B90/98 ,  A61B2017/00323 ,  A61B2017/00477 ,  A61B2034/301 ,  A61M25/0113 ,  A61M25/09041

摘要： A catheter drive cassette configured to be removably coupled to a motor drive base, comprising a first axial drive mechanism configured to drive a guide wire along its longitudinal axis; a second axial drive mechanism configured to drive a working catheter along its longitudinal axis; and a first rotational drive mechanism configured to rotate the guide wire about its longitudinal axis.

公开(公告)号：US20080097408A1

公开(公告)日：2008-04-24

申请号：US11875615

申请日：2007-10-19

申请人： John Murphy ,  Peter Strickler

发明人： John Murphy ,  Peter Strickler

IPC分类号： A61M25/16

CPC分类号： A61B5/6852 ,  A61B5/0066 ,  A61B8/12 ,  A61B8/4461

摘要： An optical catheter system comprising an intraluminal catheter that provides optical signals to a patient and carries optical signals from the patient, an outer housing, and an inner carriage that moves longitudinally relative to the outer housing and rotates relative to the outer housing during operation when the catheter system is being driven by a pullback and rotation system. The optical catheter system has an interlock system that prevents rotation and longitudinal movement of the inner carriage in the outer housing until attached to the pullback and rotation system. The pullback and rotation system comprises a frame and a catheter system interface, attached to the frame, to which the catheter system is coupled. A carriage drive system is further provided that moves longitudinally and rotates relative to the frame to provide rotation and longitudinal drive to the catheter system. A longitudinal drive system has a drive motor for advancing and/or withdrawing the carriage drive system and a manual drive input enabling a user to manually advance or withdrawal the carriage drive system. A latching system holds the carriage drive system when the catheter system is being attached to the pullback system.

摘要翻译： 一种光学导管系统，其包括管腔内导管，其向患者提供光信号并且携带来自患者的光信号，外壳和内托架，所述光信号在操作期间相对于所述外壳在纵向相对运动时相对于所述外壳旋转， 导管系统由拉回和旋转系统驱动。 光学导管系统具有互锁系统，其防止内部托架在外部壳体中的旋转和纵向运动，直到附接到回拉和旋转系统。 回拉和旋转系统包括附接到框架的框架和导管系统接口，导管系统连接到框架和导管系统接口。 还提供了一种托架驱动系统，该托架驱动系统纵向移动并相对于框架旋转以向导管系统提供旋转和纵向驱动。 纵向驱动系统具有用于前进和/或退出托架驱动系统的驱动马达和使用户能够手动前进或退出托架驱动系统的手动驱动输入。 当导管系统连接到回拉系统时，闩锁系统保持托架驱动系统。

公开(公告)号：US20070238670A1

公开(公告)日：2007-10-11

申请号：US11214997

申请日：2005-08-30

申请人： John Murphy ,  Ryan Ratts

发明人： John Murphy ,  Ryan Ratts

IPC分类号： A61K38/08 ,  C07K7/06

CPC分类号： G01N33/5076 ,  A61K38/08 ,  C07K14/34 ,  C07K14/55 ,  C07K2319/55 ,  G01N33/5011 ,  G01N33/5035 ,  G01N2510/00

摘要： In vitro delivery of the diphtheria toxin (DT) catalytic (C) domain from the lumen of purified early endosomes to the external milieu requires the addition of both ATP and a cytosolic translocation factor (CTF) complex. The results presented here demonstrate that β-COP plays an essential role in the cytosolic release of the C-domain and is mediated by a consensus peptide sequence found on several bacterial toxins and in HIV-1 reverse transcriptase. The invention features methods for inhibiting cell death that include the administration of compounds based on this consensus sequence that inhibit the translocation of the catalytic domain of toxins or transcription factors. Also featured are methods for identifying compounds that inhibit cell death, and methods for identifying compounds that promote cell death by blocking or accelerating, respectively, the rate of toxin/factor endosomal translocation.

摘要翻译： 将白喉毒素（DT）催化（C）结构域从纯化的早期内体的内部体外递送到外部环境需要添加ATP和胞质易位因子（CTF）复合物。 这里提出的结果表明β-COP在C-结构域的胞质释放中起重要作用，并且由在几种细菌毒素和HIV-1逆转录酶中发现的共有肽序列介导。 本发明的特征在于抑制细胞死亡的方法，包括基于抑制毒素或转录因子的催化结构域易位的共有序列的化合物的施用。 还特征在于鉴定抑制细胞死亡的化合物的方法，以及通过阻断或加速毒素/因子内体易位的速率来鉴定促进细胞死亡的化合物的方法。

公开(公告)号：US20070110567A1

公开(公告)日：2007-05-17

申请号：US11270925

申请日：2005-11-11

申请人： Robert Bracken ,  John Murphy ,  Stephen Swan ,  Jeffrey Simkins ,  Clement Gazzillo

发明人： Robert Bracken ,  John Murphy ,  Stephen Swan ,  Jeffrey Simkins ,  Clement Gazzillo

IPC分类号： F04D29/08

CPC分类号： F01D5/026 ,  F01D5/06 ,  F01D5/34 ,  F01D11/00 ,  F01D11/003 ,  F01D11/005 ,  F02C7/28

摘要： Disclosed herein is a rotor assembly for a steam turbine including a stacked rotor section having rotor plates. The rotor plates include a main body portion having a plate shape and a first axial face and a second axial face opposite to the first axial face. The rotor plates also include an airfoil base surface at an outer radial edge of the main body portion. The rotor plates further include buckets which extend radially outward from the airfoil base surface. And the rotor plates yet further include a seal disposed to prevent steam exposure to the first and second axial faces.

摘要翻译： 本文公开了一种用于蒸汽轮机的转子组件，其包括具有转子板的堆叠转子部分。 转子板包括具有板形状的主体部分和与第一轴向面相对的第一轴向面和第二轴向面。 转子板还包括在主体部分的外径向边缘处的翼型件基面。 转子板还包括从翼型件基部表面径向向外延伸的铲斗。 并且转子板还包括设置成防止蒸汽暴露于第一和第二轴向面的密封件。

公开(公告)号：US20070048130A1

公开(公告)日：2007-03-01

申请号：US11209624

申请日：2005-08-24

申请人： Christopher Sullivan ,  Robert Bracken ,  Jeffrey Simkins ,  Stephen Swan ,  David Fitts ,  Ronald Korzun ,  John Murphy

发明人： Christopher Sullivan ,  Robert Bracken ,  Jeffrey Simkins ,  Stephen Swan ,  David Fitts ,  Ronald Korzun ,  John Murphy

IPC分类号： F01D1/02

CPC分类号： F01D5/066 ,  F01D25/246

摘要： The steampath for a steam turbine includes stacked stator rings each mounting inwardly directed nozzles and stacked rotor wheels each mounting outwardly directed buckets mounting blades. By alternately stacking the stator rings and rotor wheels, the nozzles and buckets of the various stages are interdigitated to form a steampath. Each bucket includes a blade and a root received in a generally complementary shaped groove on a wheel.

公开(公告)号：US20060000050A1

公开(公告)日：2006-01-05

申请号：US10883147

申请日：2004-07-01

申请人： Mark Cipolla ,  Michael Wright ,  John Murphy ,  Richard Farone

发明人： Mark Cipolla ,  Michael Wright ,  John Murphy ,  Richard Farone

IPC分类号： A47L11/30

CPC分类号： A47L11/4041 ,  A47L5/28 ,  A47L7/0009 ,  A47L7/0028 ,  A47L7/0038 ,  A47L7/0042 ,  A47L11/34

摘要： A floor cleaning device (10) includes a housing (40) and a container (43) removably received by the housing. A suction nozzle (18, 18′, 18″) is fluidly connected with the container and with a suction source (52) when the container is received by the housing. A filter (114) is selectively fluidly connected with the container and with the suction source. A float (170) selectively closes the fluid connection of the filter with the container. The filter and the float may be removable as a unit (42) from the cleaning device. The nozzle may be removable, allowing an appropriate nozzle to be selected according to the type of floor surface to be cleaned.

摘要翻译： 地板清洁装置（10）包括壳体（40）和由壳体可移除地容纳的容器（43）。 当容器被壳体接收时，吸嘴（18,18'，18“）与容器流体连接并具有抽吸源（52）。 过滤器（114）与容器和抽吸源选择性地流体连接。 浮子（170）选择性地关闭过滤器与容器的流体连接。 过滤器和浮子可以作为来自清洁装置的单元（42）可移除。 喷嘴可以是可移除的，允许根据待清洁的地板表面的类型来选择适当的喷嘴。