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公开(公告)号:US20070105864A1
公开(公告)日:2007-05-10
申请号:US11598188
申请日:2006-11-08
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , David Parry , Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , M. Siddiqui , Praveen Tadikonda
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , David Parry , Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , M. Siddiqui , Praveen Tadikonda
IPC分类号: A61K31/498
CPC分类号: A61K31/4985 , A61K31/498
摘要: The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.
摘要翻译: 本发明提供使用咪唑并[1,2-a]吡嗪化合物抑制选自AKT,检查点激酶,极光激酶,Pim-1激酶和酪氨酸激酶的蛋白激酶的方法以及治疗,预防,抑制 ,或使用这些化合物改善与蛋白激酶相关的一种或多种疾病。
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公开(公告)号:US20070117804A1
公开(公告)日:2007-05-24
申请号:US11598186
申请日:2006-11-08
申请人: Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , Kamil Paruch , Timothy Guzi , Michael Dwyer , M. Siddiqui , Praveen Tadikonda
发明人: Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , Kamil Paruch , Timothy Guzi , Michael Dwyer , M. Siddiqui , Praveen Tadikonda
IPC分类号: A61K31/498 , C07D487/04
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的咪唑并吡嗪化合物作为蛋白质和/或检查点激酶的抑制剂,制备此类化合物的方法,包含一种或多种此类化合物的药物组合物,制备药物制剂的方法,包括一种或多种 化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与蛋白质或检查点激酶相关的一种或多种疾病的方法。
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3.
公开(公告)号:US20060106023A1
公开(公告)日:2006-05-18
申请号:US11272392
申请日:2005-11-10
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , M. Siddiqui
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , M. Siddiqui
IPC分类号: A61K31/506 , A61K31/498 , C07D487/02
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的咪唑并[1,2-a]吡嗪化合物作为细胞周期蛋白依赖性激酶的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备药物制剂的方法 包括一种或多种这样的化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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4.
公开(公告)号:US20070072882A1
公开(公告)日:2007-03-29
申请号:US11543182
申请日:2006-10-04
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , M. Siddiqui , Panduranga Reddy , David Belanger , Blake Hamann , Patrick Curran
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , M. Siddiqui , Panduranga Reddy , David Belanger , Blake Hamann , Patrick Curran
IPC分类号: A61K31/519 , C07D487/04
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases (CDKs), methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类作为细胞周期蛋白依赖性激酶(CDK)抑制剂的吡唑并[1,5-a]嘧啶化合物,制备这些化合物的方法,含有一种或多种这类化合物的药物组合物,制备方法 包含一种或多种这样的化合物的药物制剂,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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公开(公告)号:US20080027063A1
公开(公告)日:2008-01-31
申请号:US11758243
申请日:2007-06-05
申请人: Lianyun Zhao , Panduranga Reddy , Neng-Yang Shih , Kamil Paruch , Timothy Guzi , M. Siddiqui
发明人: Lianyun Zhao , Panduranga Reddy , Neng-Yang Shih , Kamil Paruch , Timothy Guzi , M. Siddiqui
IPC分类号: A61K31/4985 , A61P35/00 , C07D487/04
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的咪唑并吡嗪化合物作为蛋白质和/或检查点激酶的抑制剂,制备此类化合物的方法,包含一种或多种此类化合物的药物组合物,制备药物制剂的方法,包括一种或多种 化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与蛋白质或检查点激酶相关的一种或多种疾病的方法。
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公开(公告)号:US20070082900A1
公开(公告)日:2007-04-12
申请号:US11542801
申请日:2006-10-04
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , David Parry
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , David Parry
IPC分类号: A61K31/5377 , A61K31/519
CPC分类号: A61K31/519 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要: The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim kinases, and tyrosine kinase using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.
摘要翻译: 本发明提供使用吡唑并[1,5-a]嘧啶化合物抑制选自AKT,检查点激酶,极光激酶,Pim激酶和酪氨酸激酶的蛋白激酶的方法,以及治疗,预防,抑制或 使用这种化合物改善与蛋白激酶相关的一种或多种疾病。
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7.
公开(公告)号:US20070281951A1
公开(公告)日:2007-12-06
申请号:US11788856
申请日:2007-04-20
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Marc Labroli , Kartik Keertikar
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Marc Labroli , Kartik Keertikar
IPC分类号: A61K31/495
CPC分类号: A61K31/519 , A61K45/06 , A61K2300/00
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的组合物,制备药物制剂的方法,包括 一种或多种这样的化合物,以及使用这些化合物或组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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公开(公告)号:US20070054925A1
公开(公告)日:2007-03-08
申请号:US11396079
申请日:2006-03-31
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
IPC分类号: A61K31/519 , C07D487/04
CPC分类号: C07D487/04 , A61K31/495
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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9.
公开(公告)号:US20070054906A1
公开(公告)日:2007-03-08
申请号:US11396001
申请日:2006-03-31
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
IPC分类号: A61K31/5377 , A61K31/519 , C07D487/04
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备药物制剂的方法 包括一种或多种这样的化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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10.
公开(公告)号:US20060030555A1
公开(公告)日:2006-02-09
申请号:US11238597
申请日:2005-09-29
申请人: Michael Dwyer , Timothy Guzi , Kamil Paruch , Ronald Doll , Kartik Keertikar , Viyyoor Girijavallabhan
发明人: Michael Dwyer , Timothy Guzi , Kamil Paruch , Ronald Doll , Kartik Keertikar , Viyyoor Girijavallabhan
IPC分类号: C07D471/02 , A61K31/55 , A61K31/496 , A61K31/4745
CPC分类号: C07D471/04
摘要: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的咪唑并[1,2-a]吡啶化合物作为细胞周期蛋白依赖性激酶的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备药物制剂的方法 包括一种或多种这样的化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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