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1.发明申请公开(公告)号：US20120150049A1
公开(公告)日：2012-06-14
申请号：US13314594
申请日：2011-12-08
IPC分类号： A61B5/02
CPC分类号： A61B5/027 , A61B5/0002 , A61B5/0295 , A61B5/0538 , A61B18/1492 , A61B2017/00026 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00875
摘要： An implantable medical device system and associated method deliver drive signals having different frequencies to establish vector fields comprising an arterial volume and a venous volume corresponding to targeted portion of a patient's body. Impedance signals are determined in response to drive signals having different frequencies. Impedance parameter values are determined over time. A change in the hemodynamic status of a targeted portion of the patient's body is identified in response to the impedance parameter values.
摘要翻译： 可植入医疗装置系统和相关方法提供具有不同频率的驱动信号以建立包括对应于患者身体的目标部分的动脉体积和静脉体积的矢量场。 响应于具有不同频率的驱动信号来确定阻抗信号。 阻抗参数值随时间确定。 响应于阻抗参数值来识别患者身体的目标部分的血液动力学状态的变化。
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2.发明申请公开(公告)号：US20120150169A1
公开(公告)日：2012-06-14
申请号：US13314626
申请日：2011-12-08
IPC分类号： A61B18/00
CPC分类号： A61B5/027 , A61B5/0002 , A61B5/0295 , A61B5/0538 , A61B18/1492 , A61B2017/00026 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00875
摘要： A system and method for deliverying an ablation therapy that includes delivering the ablation therapy, delivering drive signals to establish a drive signal vector fields, determining impedance signals in response to the drive signals, determining a first impedance parameter in response to the first impedance signal and a second impedance parameter in response to the second impedance signal, determining whether there is a change in a hemodynamic status of the tissue subsequent to delivery of the ablation therapy in response to the first impedance parameter and the second impedance parameter, and adjusting delivery of the ablation therapy in response to determining whether there is a change in a hemodynamic status of the tissue.
摘要翻译： 一种用于递送消融治疗的系统和方法，包括递送消融治疗，递送驱动信号以建立驱动信号矢量场，响应于驱动信号确定阻抗信号，响应于第一阻抗信号确定第一阻抗参数，以及 响应于所述第二阻抗信号的第二阻抗参数，确定响应于所述第一阻抗参数和所述第二阻抗参数在所述消融治疗递送之后所述组织的血液动力学状态是否发生变化，以及调整所述第二阻抗参数 响应于确定组织的血液动力学状态是否存在变化而进行的消融治疗。
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公开(公告)号：US20150045848A1
公开(公告)日：2015-02-12
申请号：US13961963
申请日：2013-08-08
CPC分类号： A61N1/3601 , A61B5/0205 , A61B5/02405 , A61B5/0809 , A61B5/0816 , A61B5/6869 , A61B5/6877 , A61N1/36521 , A61N1/36585
摘要： Medical devices and methods for providing breathing therapy (e.g., for treating heart failure, hypertension, etc.) may determine at least the inspiration phase of one or more breathing cycles based on the monitored physiological parameters and control delivery of a plurality of breathing therapy sessions (e.g., each of the breathing therapy sessions may be provided during a defined time period). Further, each of the plurality of breathing therapy sessions may include delivering stimulation after the start of the inspiration phase of each of a plurality of breathing cycles to prolong diaphragm contraction during the breathing cycle.
摘要翻译： 用于提供呼吸治疗（例如，用于治疗心力衰竭，高血压等）的医疗装置和方法可以基于所监测的生理参数和多个呼吸治疗会话的控制递送来至少确定一个或多个呼吸周期的吸气阶段 （例如，可以在限定的时间段内提供每个呼吸治疗会话）。 此外，多个呼吸治疗会话中的每一个可以包括在多个呼吸周期中的每一个呼吸循环的启动阶段开始之后递送刺激，以在呼吸循环期间延长膜片收缩。
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公开(公告)号：US08509902B2
公开(公告)日：2013-08-13
申请号：US13192914
申请日：2011-07-28
IPC分类号： A61N1/365
CPC分类号： A61N1/3655 , A61N1/3601 , A61N1/3611 , A61N1/36521
摘要： Medical devices and methods for providing breathing therapy (e.g., for treating heart failure, hypertension, etc.) may determine at least the inspiration phase of one or more breathing cycles based on the monitored physiological parameters and control delivery of a plurality of breathing therapy sessions (e.g., each of the breathing therapy sessions may be provided during a defined time period). Further, each of the plurality of breathing therapy sessions may include delivering stimulation after the start of the inspiration phase of each of a plurality of breathing cycles to prolong diaphragm contraction during the breathing cycle.
摘要翻译： 用于提供呼吸治疗（例如，用于治疗心力衰竭，高血压等）的医疗装置和方法可以基于所监测的生理参数和多个呼吸治疗会话的控制递送来至少确定一个或多个呼吸周期的吸气阶段 （例如，可以在限定的时间段内提供每个呼吸治疗会话）。 此外，多个呼吸治疗会话中的每一个可以包括在多个呼吸周期中的每一个呼吸循环的启动阶段开始之后递送刺激，以在呼吸循环期间延长膜片收缩。
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公开(公告)号：US20130030488A1
公开(公告)日：2013-01-31
申请号：US13192914
申请日：2011-07-28
CPC分类号： A61N1/3655 , A61N1/3601 , A61N1/3611 , A61N1/36521
摘要： Medical devices and methods for providing breathing therapy (e.g., for treating heart failure, hypertension, etc.) may determine at least the inspiration phase of one or more breathing cycles based on the monitored physiological parameters and control delivery of a plurality of breathing therapy sessions (e.g., each of the breathing therapy sessions may be provided during a defined time period). Further, each of the plurality of breathing therapy sessions may include delivering stimulation after the start of the inspiration phase of each of a plurality of breathing cycles to prolong diaphragm contraction during the breathing cycle.
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6.发明申请Absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction 有权绝对校准组织氧饱和度和总血红蛋白体积分数公开(公告)号：US20100317940A1
公开(公告)日：2010-12-16
申请号：US12797800
申请日：2010-06-10
申请人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis , Richard J. O'Brien , Yong K. Cho , Thomas J. Mullen , Avram Scheiner , Rodolphe P. Katra
发明人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis , Richard J. O'Brien , Yong K. Cho , Thomas J. Mullen , Avram Scheiner , Rodolphe P. Katra
IPC分类号： A61B5/1455
CPC分类号： A61N1/36557 , A61B5/1459 , A61N1/37258
摘要： A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.
摘要翻译： 用于监测患者状况的医疗装置包括能够经血管内先进地沿着组织体积定位的传感器，所述传感器包括光源和光检测器的第一组合，以将光发射到一定体积的组织中并且检测 通过组织体积散射的光并产生对应于检测到的光的强度的第一输出信号。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号并且使用 光检测器输出信号。
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7.发明授权Absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction 有权绝对校准组织氧饱和度和总血红蛋白体积分数公开(公告)号：US08463346B2
公开(公告)日：2013-06-11
申请号：US12797800
申请日：2010-06-10
申请人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis , Richard J. O'Brien , Yong K. Cho , Thomas J. Mullen , Avram Scheiner , Rodolphe P. Katra
发明人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis , Richard J. O'Brien , Yong K. Cho , Thomas J. Mullen , Avram Scheiner , Rodolphe P. Katra
IPC分类号： A61B5/00
CPC分类号： A61N1/36557 , A61B5/1459 , A61N1/37258
摘要： A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.
摘要翻译： 用于监测患者状况的医疗装置包括能够经血管内先进地沿着组织体积定位的传感器，所述传感器包括光源和光检测器的第一组合，以将光发射到一定体积的组织中并且检测 通过组织体积散射的光并产生对应于检测到的光的强度的第一输出信号。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号并且使用 光检测器输出信号。
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8.发明授权Absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction 有权绝对校准组织氧饱和度和总血红蛋白体积分数公开(公告)号：US08346332B2
公开(公告)日：2013-01-01
申请号：US12797811
申请日：2010-06-10
申请人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis , Richard J. O'Brien , Yong K. Cho , Thomas J. Mullen , Avram Scheiner , Rodolphe P. Katra
发明人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis , Richard J. O'Brien , Yong K. Cho , Thomas J. Mullen , Avram Scheiner , Rodolphe P. Katra
IPC分类号： A61B5/00
CPC分类号： A61N1/36557 , A61B5/1459 , A61N1/37258
摘要： A medical device for monitoring a patient condition includes a first combination of a light source and a light detector to emit light into a volume of tissue, detect light scattered by the volume of tissue, and provide a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal, compute a measure of tissue oxygenation in response to the light detector output signal, and detect tissue hypoxia using the measure of tissue oxygenation.
摘要翻译： 用于监测患者状况的医疗装置包括光源和光检测器的第一组合，以将光发射到组织的体积中，检测由组织体积散射的光，并提供对应于组织的强度的第一输出信号 检测到光。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号，计算响应中组织氧合的量度 到光检测器输出信号，并使用组织氧合的测量来检测组织缺氧。
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9.发明申请ABSOLUTE CALIBRATED TISSUE OXYGEN SATURATION AND TOTAL HEMOGLOBIN VOLUME FRACTION 有权绝对的校准组织氧饱和度和总HEMOGLOBIN体积分数公开(公告)号：US20100317941A1
公开(公告)日：2010-12-16
申请号：US12797811
申请日：2010-06-10
申请人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis , Richard J. O'Brien , Yong K. Cho , Thomas J. Mullen , Avram Scheiner , Rodolphe P. Katra
发明人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis , Richard J. O'Brien , Yong K. Cho , Thomas J. Mullen , Avram Scheiner , Rodolphe P. Katra
IPC分类号： A61B5/1455
CPC分类号： A61N1/36557 , A61B5/1459 , A61N1/37258
摘要： A medical device for monitoring a patient condition includes a first combination of a light source and a light detector to emit light into a volume of tissue, detect light scattered by the volume of tissue, and provide a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal, compute a measure of tissue oxygenation in response to the light detector output signal, and detect tissue hypoxia using the measure of tissue oxygenation.
摘要翻译： 用于监测患者状况的医疗装置包括光源和光检测器的第一组合，以将光发射到组织的体积中，检测由组织体积散射的光，并提供对应于组织的强度的第一输出信号 检测到光。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号，计算响应中组织氧合的量度 到光检测器输出信号，并使用组织氧合的测量来检测组织缺氧。
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10.发明授权Techniques for placing medical leads for electrical stimulation of nerve tissue 有权放置用于电刺激神经组织的医疗线的技术公开(公告)号：US09572982B2
公开(公告)日：2017-02-21
申请号：US12433766
申请日：2009-04-30
申请人： John E. Burnes , Kenneth C. Gardeski , Ruth N. Klepfer , Patrick E. Macaulay , Mary M. Morris , Avram Scheiner
发明人： John E. Burnes , Kenneth C. Gardeski , Ruth N. Klepfer , Patrick E. Macaulay , Mary M. Morris , Avram Scheiner
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.
摘要翻译： 本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。
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