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1.发明申请公开(公告)号：US20120150049A1
公开(公告)日：2012-06-14
申请号：US13314594
申请日：2011-12-08
IPC分类号： A61B5/02
CPC分类号： A61B5/027 , A61B5/0002 , A61B5/0295 , A61B5/0538 , A61B18/1492 , A61B2017/00026 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00875
摘要： An implantable medical device system and associated method deliver drive signals having different frequencies to establish vector fields comprising an arterial volume and a venous volume corresponding to targeted portion of a patient's body. Impedance signals are determined in response to drive signals having different frequencies. Impedance parameter values are determined over time. A change in the hemodynamic status of a targeted portion of the patient's body is identified in response to the impedance parameter values.
摘要翻译： 可植入医疗装置系统和相关方法提供具有不同频率的驱动信号以建立包括对应于患者身体的目标部分的动脉体积和静脉体积的矢量场。 响应于具有不同频率的驱动信号来确定阻抗信号。 阻抗参数值随时间确定。 响应于阻抗参数值来识别患者身体的目标部分的血液动力学状态的变化。
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2.发明申请公开(公告)号：US20120150169A1
公开(公告)日：2012-06-14
申请号：US13314626
申请日：2011-12-08
IPC分类号： A61B18/00
CPC分类号： A61B5/027 , A61B5/0002 , A61B5/0295 , A61B5/0538 , A61B18/1492 , A61B2017/00026 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00875
摘要： A system and method for deliverying an ablation therapy that includes delivering the ablation therapy, delivering drive signals to establish a drive signal vector fields, determining impedance signals in response to the drive signals, determining a first impedance parameter in response to the first impedance signal and a second impedance parameter in response to the second impedance signal, determining whether there is a change in a hemodynamic status of the tissue subsequent to delivery of the ablation therapy in response to the first impedance parameter and the second impedance parameter, and adjusting delivery of the ablation therapy in response to determining whether there is a change in a hemodynamic status of the tissue.
摘要翻译： 一种用于递送消融治疗的系统和方法，包括递送消融治疗，递送驱动信号以建立驱动信号矢量场，响应于驱动信号确定阻抗信号，响应于第一阻抗信号确定第一阻抗参数，以及 响应于所述第二阻抗信号的第二阻抗参数，确定响应于所述第一阻抗参数和所述第二阻抗参数在所述消融治疗递送之后所述组织的血液动力学状态是否发生变化，以及调整所述第二阻抗参数 响应于确定组织的血液动力学状态是否存在变化而进行的消融治疗。
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3.发明申请公开(公告)号：US20100030087A1
公开(公告)日：2010-02-04
申请号：US12263065
申请日：2008-10-31
IPC分类号： A61B5/0215 , A61B5/053
CPC分类号： A61N1/36521 , A61B5/021 , A61B5/0215 , A61B5/02158 , A61B5/053 , A61B5/0535 , A61B5/0538 , A61B5/7239 , A61N1/36564
摘要： Techniques for estimating a cardiac chamber or vascular pressure based upon impedance are described. A device or system may measure an impedance between at least two electrodes implanted within or proximate to a cardiovascular system. The device or system may estimate a pressure of an element of the cardiovascular system based on a relationship between impedance and volume of the element, and based on a empirical relationship between the volume and the pressure. The device or system may also estimate the dimension of the element based on the impedance-volume relationship, or other characteristics based on the impedance. Because the impedance measurements may be obtained, in some examples, by using electrodes and leads implanted within the cardiovascular system and coupled to an implantable medical device, a practical estimation of a cardiovascular pressure can be obtained on a chronic basis without requiring the use other invasive sensors, such as micronanometer transducers.
摘要翻译： 描述了基于阻抗估计心室或血管压力的技术。 装置或系统可以测量植入在心血管系统内或其附近的至少两个电极之间的阻抗。 装置或系统可以基于元件的阻抗和体积之间的关系，并且基于体积和压力之间的经验关系来估计心血管系统的元件的压力。 装置或系统还可以基于阻抗 - 体积关系或基于阻抗的其它特性来估计元件的尺寸。 由于可以获得阻抗测量值，在一些示例中，通过使用植入心血管系统内并连接到可植入医疗装置的电极和引线，可以长期获得心血管压力的实际估计，而不需要使用其它侵入性 传感器，如微量计传感器。
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4.发明授权公开(公告)号：US08938292B2
公开(公告)日：2015-01-20
申请号：US12263065
申请日：2008-10-31
CPC分类号： A61N1/36521 , A61B5/021 , A61B5/0215 , A61B5/02158 , A61B5/053 , A61B5/0535 , A61B5/0538 , A61B5/7239 , A61N1/36564
摘要： Techniques for estimating a cardiac chamber or vascular pressure based upon impedance are described. A device or system may measure an impedance between at least two electrodes implanted within or proximate to a cardiovascular system. The device or system may estimate a pressure of an element of the cardiovascular system based on a relationship between impedance and volume of the element, and based on a empirical relationship between the volume and the pressure. The device or system may also estimate the dimension of the element based on the impedance-volume relationship, or other characteristics based on the impedance. Because the impedance measurements may be obtained, in some examples, by using electrodes and leads implanted within the cardiovascular system and coupled to an implantable medical device, a practical estimation of a cardiovascular pressure can be obtained on a chronic basis without requiring the use other invasive sensors, such as micronanometer transducers.
摘要翻译： 描述了基于阻抗估计心室或血管压力的技术。 装置或系统可以测量植入在心血管系统内或其附近的至少两个电极之间的阻抗。 装置或系统可以基于元件的阻抗和体积之间的关系，并且基于体积和压力之间的经验关系来估计心血管系统的元件的压力。 装置或系统还可以基于阻抗 - 体积关系或基于阻抗的其它特性来估计元件的尺寸。 由于可以获得阻抗测量值，在一些示例中，通过使用植入心血管系统内并连接到可植入医疗装置的电极和引线，可以长期获得心血管压力的实际估计，而不需要使用其它侵入性 传感器，如微量计传感器。
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公开(公告)号：US08831721B2
公开(公告)日：2014-09-09
申请号：US12108785
申请日：2008-04-24
CPC分类号： A61N1/36585 , A61B5/0535 , A61B5/0538 , A61B5/7264 , A61N1/00 , A61N1/36521 , A61N1/36564 , A61N1/3962
摘要： An implantable cardioverter defibrillator evaluates the hemodynamic stability of an arrhythmia to determine whether or not to defibrillate. The device obtains cardiac pressure and cardiac impedance data and evaluates a phase relationship between these parameters. Hemodynamically stable rhythms will result in an out of phase relationship.
摘要翻译： 植入式心律转复除颤器评估心律失常的血液动力学稳定性，以确定是否除颤。 该装置获得心脏压力和心脏阻抗数据，并评估这些参数之间的相位关系。 血液动力学稳定的节律将导致异相关系。
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公开(公告)号：US20120109245A1
公开(公告)日：2012-05-03
申请号：US12916012
申请日：2010-10-29
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/0452 , A61B5/0535 , A61B5/7239 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3987
摘要： Methods and/or devices are disclosed herein for monitoring cardiac impedance signal and delivering therapy to a patient's heart based upon the monitored cardiac impedance.
摘要翻译： 本文公开了用于监测心脏阻抗信号并基于所监测的心脏阻抗将治疗递送到患者心脏的方法和/或装置。
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公开(公告)号：US07972273B2
公开(公告)日：2011-07-05
申请号：US11184639
申请日：2005-07-19
CPC分类号： A61B5/0215 , A61B5/6882 , A61N1/36564
摘要： A pressure sensor is deployed in the right atrium and is in contact with the tissue of the fossa ovalis. The fossa ovalis acts as a membrane and the pressure sensor determines the relative and/or absolute pressure within the left atrium while remaining within the right atrium. A variety of embodiment are provided to deploy and anchor the sensor into the proper position.
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公开(公告)号：US07927282B2
公开(公告)日：2011-04-19
申请号：US11184438
申请日：2005-07-19
CPC分类号： A61B5/0215 , A61B5/6882 , A61N1/08 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： A pressure sensor is deployed in the right atrium and is in contact with the tissue of the fossa ovalis. The fossa ovalis acts as a membrane and the pressure sensor determines the relative and/or absolute pressure within the left atrium while remaining within the right atrium. A variety of embodiment are provided to deploy and anchor the sensor into the proper position.
摘要翻译： 压力传感器部署在右心房，并与卵圆窝的组织接触。 卵圆窝作为膜，压力传感器确定左心房内的相对和/或绝对压力，同时保留在右心房内。 提供了各种实施例以将传感器部署和锚定到适当的位置。
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9.发明申请公开(公告)号：US20100030086A1
公开(公告)日：2010-02-04
申请号：US12262941
申请日：2008-10-31
CPC分类号： A61N1/36521 , A61B5/021 , A61B5/0215 , A61B5/02158 , A61B5/053 , A61B5/0535 , A61B5/0538 , A61B5/7239 , A61N1/36564
摘要： This disclosure relates to monitoring intracardiac or vascular impedance to determine a change in hemodynamic status by detecting changes in an impedance parameter over cardiac cycles. An example method includes measuring a plurality of impedance values of a path within a patient over time, wherein the path includes at least one blood vessel or cardiac chamber of the patient, and wherein the impedance values vary as a function of blood pressure within the at least one vessel or chamber, determining a plurality of values of an impedance parameter over time based on the measured impedance values, wherein each of the impedance parameter values is determined based on a respective sub-plurality of the impedance values, comparing at least one of the impedance parameter values to at least one prior impedance parameter value, and identifying a change in a cardiovascular parameter related to the blood pressure based on the comparison.
摘要翻译： 本公开涉及监测心脏内或血管阻抗，以通过检测心动周期上的阻抗参数的变化来确定血液动力学状态的变化。 一个示例性方法包括测量患者随着时间的路径的多个阻抗值，其中该路径包括患者的至少一个血管或心室，并且其中阻抗值随着at 至少一个容器或室，基于所测量的阻抗值确定随时间的多个阻抗参数值，其中每个所述阻抗参数值是基于所述阻抗值的相应次级多个来确定的， 阻抗参数值至少一个先前的阻抗参数值，并且基于该比较来识别与血压相关的心血管参数的变化。
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公开(公告)号：US08435186B2
公开(公告)日：2013-05-07
申请号：US12696753
申请日：2010-01-29
IPC分类号： A61B5/00
CPC分类号： A61N1/36521 , A61B5/0031 , A61B5/0215 , A61B5/02405 , A61B5/053 , A61B5/08 , A61B5/11 , A61B5/1116 , A61B5/4035 , A61N1/36535 , A61N1/37247 , A61N1/37258
摘要： The disclosure describes techniques for quantifying the autonomic nervous system (ANS) health of a patient with thoracic impedance measurements. Thoracic impedance may be measured utilizing cardiac electrodes and an implantable medical device housing or other electrodes located on or within the patient. Since greater variability in thoracic impedance may indicate better health of the ANS, monitoring impedance changes in a patient may be used to quantify autonomic tone of the ANS, and ultimately, overall patient health. In some examples, thoracic impedance may be measured in response to a change in patient posture for acute monitoring or at predetermined times over several days, weeks, or months for more chronic monitoring of the patient. An implantable medical device may independently analyze the impedance measurements and transmit an alert to the patient or clinician when impedance changes indicate a change in patient health.
摘要翻译： 本公开描述了用于量化具有胸部阻抗测量的患者的自主神经系统（ANS）健康的技术。 可以使用心电极和位于患者内部或内部的可植入医疗装置外壳或其它电极来测量胸腔阻抗。 由于胸部阻抗变化较大可能表明ANS的健康状况良好，所以监测患者的阻抗变化可用于量化ANS的自主音调，并最终对整体患者的健康状况进行量化。 在一些示例中，可以响应于用于急性监测的患者姿势的变化或在几天，几周或几个月的预定时间来测量胸部阻抗以进行更长期的患者监测。 当阻抗变化表示患者健康状况发生变化时，植入式医疗设备可以独立地分析阻抗测量结果并向患者或临床医生发送警报。
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