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公开(公告)号：US06706277B2
公开(公告)日：2004-03-16
申请号：US10146270
申请日：2002-05-15
IPC分类号： A61K716
CPC分类号： A23G3/36 , A23G3/362 , A23G3/368 , A23G4/06 , A23G4/064 , A23G4/126 , A61K8/02 , A61K8/0216 , A61K8/24 , A61Q11/00
摘要： Disclosed are stable portable oral care confectionery compositions, which provide enhanced anti-calculus effects, optionally combined with additional oral care benefits. The present invention also relates to use of such compositions to provide improved surface conditioning effects and reduced metal astringency. The confectionery compositions comprise: (i) greater than about 1% of a polyphosphate material having an average anion chain length of greater than or equal to 4; (ii) less than about 10% water; and (iii) a suitable confectionery carrier material comprising less than about 2% elastomer by weight of the composition.
摘要翻译： 公开了稳定的便携式口腔护理糖食组合物，其提供增强的抗结石作用，任选地与额外的口腔护理益处组合。 本发明还涉及这种组合物的用途，以提供改善的表面调理效果和降低的金属收敛性。 糖食组合物包含：（i）大于约1％的平均阴离子链长度大于或等于4的聚磷酸盐材料;（ii）小于约10％的水; 和（iii）合适的糖食载体材料，其包含按组合物的重量计小于约2％的弹性体。
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公开(公告)号：US06926916B1
公开(公告)日：2005-08-09
申请号：US09831462
申请日：2000-06-22
摘要： The present invention relates to chewing gum composition comprising a polymeric surface active agent. A second aspect of this invention relates to a crunchy chewing gum wherein the crunchy texture is provided by particulate polyphosphate particles within the formulation and which lasts through the initial minutes of mastication. The chewing gum composition may also contain a cationic material and or an orally active metallic ion. The chewing gum composition will provide surface conditioning effects on a subject's teeth and or oral mucosa and the crunchy texture is used as a sensate to reinforce these effects. The surface conditioning effects can be measured through in vitro or in vivo testing. The in vitro testing shows a total surface energy and or a lewis base score to increase immediately after treatment with the chewing gum and then decrease over time. The in vivo testing shows a water contact angle of the oral mucosa to decrease after treatment with the chewing gum composition and/or a significantly higher smooth teeth feel relative to other chewing gum compositions. The present invention also relates to methods of providing surface conditioning effects to a subject comprising administering to the subject a chewing gum comprising a polymeric surface active agent. The present invention also relates to methods of reducing astringency of a chewing gum containing an orally active metallic ion without significantly reducing the efficacy of the metallic ion.
摘要翻译： 本发明涉及包含聚合物表面活性剂的口香糖组合物。 本发明的第二方面涉及一种松脆的口香糖，其中脆性质地由制剂内的颗粒聚磷酸盐颗粒提供，并持续通过咀嚼的最初几分钟。 口香糖组合物还可以含有阳离子材料和/或口服活性金属离子。 口香糖组合物将对受试者的牙齿和/或口腔粘膜提供表面调理作用，并且使用脆性质地作为增强这些效果的感觉。 表面调理效果可以通过体外或体内测试来测量。 体外测试显示用口香糖处理后立即增加总表面能和路易斯基分数，然后随着时间的推移而降低。 体内测试显示了口腔粘膜组合物处理后口腔粘膜的水接触角降低，和/或相对于其他口香糖组合物显着更高的平滑牙齿感觉。 本发明还涉及向受试者提供表面调理作用的方法，包括对受试者施用包含聚合物表面活性剂的口香糖。 本发明还涉及减少含有口服活性金属离子的口香糖的涩味的方法，而不显着降低金属离子的功效。
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公开(公告)号：US08858580B2
公开(公告)日：2014-10-14
申请号：US13099531
申请日：2011-05-03
CPC分类号： A61B17/244 , A46B15/0002 , A46B15/0022 , A46B15/0081 , A61B90/30 , A61B2017/00398 , A61B2017/00734 , A61N1/0548 , A61N1/322
摘要： A head portion for a tongue cleaning device is disclosed. The head portion includes a mechanical tongue cleaning section and a tongue cleaning electrode. The mechanical tongue cleaning section includes a cleaning protrusion. The tongue cleaning electrode enables a current flow into a user's tongue during operation.
摘要翻译： 公开了一种用于舌头清洁装置的头部。 头部包括机械舌部清洁部分和舌头清洁电极。 机械舌头清洁部分包括清洁突起。 舌头清洁电极使得在操作期间电流流入使用者的舌头。
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公开(公告)号：US5939052A
公开(公告)日：1999-08-17
申请号：US754577
申请日：1996-11-21
申请人： Donald James White, Jr. , William Michael Glandorf , Stephen Francis McClanahan , Edward Russell Cox , Paul Donald Estes
发明人： Donald James White, Jr. , William Michael Glandorf , Stephen Francis McClanahan , Edward Russell Cox , Paul Donald Estes
IPC分类号： A61K8/92 , A61K8/19 , A61K8/21 , A61K8/24 , A61K8/25 , A61K8/29 , A61K8/34 , A61K8/36 , A61K8/38 , A61K8/40 , A61K8/72 , A61K8/73 , A61K8/90 , A61P1/02 , A61Q11/00 , A61K7/16 , A61K7/18
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/21 , A61K8/24 , A61K8/90 , A61K2800/52 , A61K2800/88
摘要： Disclosed are oral formulations contained in physically separated compartments of a dentifrice dispenser, comprising a first dentifrice composition and a second dentifrice composition. The first dentifrice composition comprises an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more, an effective amount of a buffering agents, and one or more aqueous carriers, wherein the first dentifrice composition has a total water content of from about 5% to about 20%. The second dentifrice compsoition comprises a soluble fluoride ion source, an effective amount of a buffering agents, and one or more aqueous carriers.
摘要翻译： 公开了包含在洁齿剂分配器的物理分离的隔室中的口服制剂，其包含第一洁牙剂组合物和第二洁齿剂组合物。 第一洁牙剂组合物包含有效量的一种或多种平均链长为约4或更大的线性多磷酸盐，有效量的缓冲剂和一种或多种含水载体，其中第一洁牙剂组合物具有总含水量 为约5％至约20％。 第二洁齿剂组合物包含可溶性氟化物离子源，有效量的缓冲剂和一种或多种含水载体。
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公开(公告)号：US07387774B2
公开(公告)日：2008-06-17
申请号：US10734381
申请日：2003-12-12
IPC分类号： A61K7/16
CPC分类号： A23G4/06 , A23G4/08 , A23G4/126 , A61K6/0017 , A61K8/19 , A61K8/21 , A61K8/24 , A61K8/81 , A61K8/8147 , A61K2800/52 , A61Q11/00 , C08L33/08 , C08L33/10
摘要： Disclosed are methods of enhancing fluoride incorporation into teeth and mineralization of teeth by use of oral care compositions comprising the combination of one or more fluoride ion sources and specialized phosphonate containing polymers or telomers. The present methods provide enhanced protection of teeth against caries and cavities and increased resistance to acid demineralization associated with caries processes as well as anticalculus (antitartar) benefits.
摘要翻译： 公开了通过使用包含一种或多种氟离子源和含有特定膦酸酯的聚合物或调聚物的组合的口腔护理组合物来增强氟掺入牙齿和使牙齿矿化的方法。 本发明的方法提供了牙齿抵抗龋齿和空腔的增强的保护，并且增加了与龋齿过程以及抗牙垢（antitartar）益处相关的酸脱盐的抗性。
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公开(公告)号：US06740311B2
公开(公告)日：2004-05-25
申请号：US10178275
申请日：2002-06-24
IPC分类号： A61K716
摘要： Oral care compositions comprising unique silica abrasives and methods for polishing and cleaning dental enamel using these oral care compositions are disclosed.
摘要翻译： 公开了包含独特的二氧化硅研磨剂和使用这些口腔护理组合物抛光和清洁牙釉质的口腔护理组合物。
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7.发明授权Dentifrice compositions containing &bgr;-phase calcium pyrophosphate an anticalculus agent, and fluoride 失效含有β-相钙焦磷酸盐的防腐剂组合物，抗结石剂和氟化物公开(公告)号：US06241974B1
公开(公告)日：2001-06-05
申请号：US08839225
申请日：1997-04-22
IPC分类号： A61K716
摘要： Disclosed are dentifrice compositions comprising from about 30% to about 45% of &bgr;-phase calcium pyrophosphate, an anticalculus agent, a soluble fluoride ion source capable of providing from about 50 ppm to about 3500 ppm of free fluoride ions, and one or more aqueous carriers. The anticalculus agent may be a polyphosphonate source, a polyphosphate source, or a pyrophosphate source.
摘要翻译： 公开了含有约30％至约45％的β相焦磷酸钙的洁牙剂组合物，抗结石剂，能够提供约50ppm至约3500ppm的游离氟离子的可溶性氟离子源，以及一种或多种含水 承运人 抗结石剂可以是聚膦酸盐源，多磷酸盐源或焦磷酸盐源。
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公开(公告)号：US09192762B2
公开(公告)日：2015-11-24
申请号：US13615667
申请日：2012-09-14
申请人： Alexander F. Doll , Julie Myers Grender , Phyllis D. Hoke , Malgorzata Klukowska , David Salloum , Donald James White, Jr. , Soujanya Chinnapareddy
发明人： Alexander F. Doll , Julie Myers Grender , Phyllis D. Hoke , Malgorzata Klukowska , David Salloum , Donald James White, Jr. , Soujanya Chinnapareddy
CPC分类号： A61N1/322 , A46B15/00 , A46B15/0008 , A46B15/0022 , A46B15/0024 , A46B2200/1066 , A61C17/22 , A61C17/221 , A61C17/222 , A61C19/04 , A61N1/26 , A61N1/306 , A61N1/32 , A61N5/0601
摘要： A therapeutic micro-current delivery device includes a first electrode in electrical contact with a user at a first user location, a second electrode in electrical contact with the user at a second user location, a power source operable to provide a first voltage potential at the first electrode and a second voltage potential at the second electrode, and a micro-current control circuit in electrical communication with the first electrode, second electrode and power source. Electrical contact of the first electrode at the first user location and electrical contact of the second electrode at the second user location completes an electrical circuit. The micro-current control circuit generates a micro-current Iramped through a user between the first location and the second location that increases from a start current Istart to an end current Iend over a rise time trise. Oral care devices and micro-current control methods are also disclosed.
摘要翻译： 治疗性微电流输送装置包括在第一使用者位置与用户电接触的第一电极，在第二用户位置与用户电接触的第二电极，可操作以在第二用户位置处提供第一电压电位的电源 第一电极和第二电极处的第二电压电位，以及与第一电极，第二电极和电源电连通的微电流控制电路。 第一用户位置处的第一电极的电接触和第二电极在第二用户位置的电接触完成电路。 微电流控制电路通过用户在第一位置和第二位置之间通过用户在上升时间trise上从起动电流Istart到结束电流Iend产生微弱电流。 还公开了口腔护理装置和微电流控制方法。
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公开(公告)号：US06677391B1
公开(公告)日：2004-01-13
申请号：US09716810
申请日：2000-11-20
申请人： Jayanth Rajaiah , Kimberly Ann Gilday-Weber , Lisa Catron Ernst , William Michael Glandorf , Donald James White, Jr.
发明人： Jayanth Rajaiah , Kimberly Ann Gilday-Weber , Lisa Catron Ernst , William Michael Glandorf , Donald James White, Jr.
IPC分类号： A61K608
CPC分类号： A61K6/097 , A61K6/0026 , Y10T442/3854 , Y10T442/3886 , Y10T442/3894 , Y10T442/3959 , C08L1/284 , C08L5/04 , C08L29/04 , C08L1/286 , C08L35/00 , C08L39/06 , C08L25/08 , C08L33/26 , C08L33/08 , C08L79/00 , C08L67/02 , C08L5/08
摘要： The present invention relates to a non-aqueous denture adhesive composition comprising a safe and effective adhesive amount of a denture adhesive; a safe and effective amount of an anticalculus agent; and a non-aqueous denture adhesive carrier; wherein the anticalculus agent is a material effective in reducing calcium phosphate mineral deposition related to calculus formation. The present invention further relates to a method of delivering an anticalculus agent to the oral cavity and teeth, by applying the above composition to dentures, directly to the oral cavity, or applying it to both, and thereafter securing the dentures to the oral cavity.
摘要翻译： 本发明涉及一种非水性义齿粘合剂组合物，其包含安全有效的粘合剂量的义齿粘合剂; 安全有效量的抗牙垢剂; 和非水性义齿粘合剂载体; 其中所述防牙垢剂是有效减少与结石形成相关的磷酸钙矿物沉积的材料。 本发明还涉及通过将上述组合物直接应用于口腔或将其施用于口腔，然后将义齿固定到口腔上，将抗牙垢剂递送至口腔和牙齿的方法。
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10.发明授权公开(公告)号：US06190644B1
公开(公告)日：2001-02-20
申请号：US08754439
申请日：1996-11-21
IPC分类号： A61K716
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/21 , A61K8/24 , A61K2800/52
摘要： Disclosed are oral compositions comprising one or more linear polyphosphates having an average chain length of about 4 or more, sodium monofluorophosphate, a buffering agent, an abrasive polishing material containing less than 23% calcium, and one or more aqueous carriers, wherein the oral composition has a total water content of from about 5% to about 20%.
摘要翻译： 公开了包含一种或多种平均链长为约4或更多的线性多磷酸盐，单氟磷酸钠，缓冲剂，含有少于23％钙的磨料抛光材料和一种或多种含水载体的口腔组合物，其中口腔组合物 总含水量为约5％至约20％。
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