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公开(公告)号：US06946131B2
公开(公告)日：2005-09-20
申请号：US10368044
申请日：2003-02-19
申请人： Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz , Israel Vlodavsky , Yael Friedmann
发明人： Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz , Israel Vlodavsky , Yael Friedmann
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07K16/40 , C12N5/10 , C12N9/24 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/15 , G01N33/573 , G01N33/577
CPC分类号： C07K16/40 , A61K38/00 , A61K2039/505 , C12N9/2402 , C12Y302/01166 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： A method of treating a condition associated with heparanase expression by administering a heparanase activity neutralizing monoclonal anti-heparanase antibody, the monoclonal anti-heparanase antibody being for neutralizing heparanase catalytic activity.
摘要翻译： 通过施用乙酰肝素酶活性中和单克隆抗肝素酶抗体来治疗与肝素酶表达相关的病症的方法，所述单克隆抗肝素酶抗体用于中和肝素酶催化活性。
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公开(公告)号：US06562950B2
公开(公告)日：2003-05-13
申请号：US09186200
申请日：1998-11-04
申请人： Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz , Israel Vlodavsky , Yael Friedmann
发明人： Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz , Israel Vlodavsky , Yael Friedmann
IPC分类号： C07K1640
CPC分类号： C07K16/40 , A61K38/00 , A61K2039/505 , C12N9/2402 , C12Y302/01166 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： A monoclonal antibody elicited by a heparanase protein or an immunogenical portion thereof, the monoclonal antibody specifically inhibits heparanase activity.
摘要翻译： 由肝素酶蛋白或其免疫原性部分引发的单克隆抗体，单克隆抗体特异性抑制乙酰肝素酶活性。
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3.发明申请Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies 审中-公开肝素酶活性中和抗肝素酶单克隆抗体和其他抗肝素酶抗体公开(公告)号：US20060269552A1
公开(公告)日：2006-11-30
申请号：US10559925
申请日：2004-06-03
申请人： Oron Yacoby-Zeevi , Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz
发明人： Oron Yacoby-Zeevi , Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/73 , C07K2317/76 , C12Q1/34 , G01N33/6893
摘要： Specific anti-heparanase antibodies which bind specifically to heparanase having sequence homology to human heparanase, which can be used to treat and diagnose conditions associated with heparanase catalytic activity, for purification of heparanase, and for drug development in heparanase associated conditions are disclosed.
摘要翻译： 公开了特异性抗乙酰肝素酶抗体，其特异性结合具有与人类乙酰肝素酶具有序列同源性的乙酰肝素酶，其可用于治疗和诊断与肝素酶催化活性相关的病症，用于纯化乙酰肝素酶和用于乙酰肝素酶相关病症中的药物开发。
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公开(公告)号：US06475763B1
公开(公告)日：2002-11-05
申请号：US09487716
申请日：2000-01-19
申请人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madlene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Shlomi
发明人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madlene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Shlomi
IPC分类号： C12Q100
CPC分类号： C12Y302/01166 , A61K38/00 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.
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5.发明授权Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe 失效使用哺乳动物肝素酶作为探针筛选潜在的抗转移和抗炎药的方法公开(公告)号：US06190875B1
公开(公告)日：2001-02-20
申请号：US09113168
申请日：1998-07-10
申请人： Hanna Ben-Artzi , Maty Ayal-Hershkovitz , Israel Vlodavsky , Iris Pecker , Yoav Peleg , Daphna Miron
发明人： Hanna Ben-Artzi , Maty Ayal-Hershkovitz , Israel Vlodavsky , Iris Pecker , Yoav Peleg , Daphna Miron
IPC分类号： C12Q134
CPC分类号： C12Y302/01166 , A61K38/00 , A61L27/34 , C12N9/2402 , C12Q1/34 , C12Q1/527 , G01N2333/924 , G01N2333/988 , G01N2400/40 , G01N2500/20
摘要： Qualitative and quantitative methods of testing an agent for its potential at inhibiting glycosidase catalytic activity, the methods including the steps of interacting a glycosidase enzyme with a glycosidase substrate in a presence of the agent and qualitatively or quantitatively evaluating an effect of the agent on the catalytic activity of the glycosidase enzyme toward the glycosidase substrate. Preferably the glycosidase enzyme is a heparanase enzyme and the glycosidase substrate is, respectively, a heparanase substrate.
摘要翻译： 测定其抑制糖苷酶催化活性潜力的试剂的定性和定量方法，所述方法包括在试剂存在下将糖苷酶与糖苷酶底物相互作用的步骤，并定性或定量地评估试剂对催化剂的作用 糖苷酶对糖苷酶底物的活性。 优选地，糖苷酶是乙酰肝素酶，糖苷酶底物分别是乙酰肝素酶底物。
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6.发明授权Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same 有权用于表达重组肝素酶的转基因细胞和方法及其纯化方法公开(公告)号：US06348344B1
公开(公告)日：2002-02-19
申请号：US09260038
申请日：1999-03-02
申请人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madelene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Schlomi
发明人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madelene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Schlomi
IPC分类号： C12N942
CPC分类号： C12Y302/01166 , A61K38/00 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.
摘要翻译： 细菌，酵母和动物细胞和细胞系中过表达重组肝素酶的方法，从其中纯化重组肝素酶的方法和通过蛋白水解产生高活性乙酰肝素酶的前体的修饰的乙酰肝素酶。
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7.发明授权Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same 有权用于表达重组肝素酶的转基因细胞和方法及其纯化方法公开(公告)号：US06426209B1
公开(公告)日：2002-07-30
申请号：US09635923
申请日：2000-08-10
IPC分类号： C12N900
CPC分类号： C12Y302/01166 , A61K38/00 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： A preparation containing an enzymatically inactive form of heparanase, said enzymatically inactive form of heparanase being cleavable into an enzimatically active form of heparanase.
摘要翻译： 含有酶促无活性形式的乙酰肝素酶的制剂，所述酶促无活性形式的乙酰肝素酶可切割成酶活性形式的乙酰肝素酶。
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公开(公告)号：US06630295B2
公开(公告)日：2003-10-07
申请号：US09753692
申请日：2001-01-04
IPC分类号： C12Q100
CPC分类号： C12Q1/34 , C12Q1/68 , G01N2500/00 , C12Q2561/119
摘要： A method of testing an agent for its potential at modulating induction of a molecular weight change of a first polyion is disclosed. The method is effected by (a) subjecting the first polyion to conditions under-which the first polyion undergoing the molecular weight change in a presence, in an absence or under several different concentrations of the agent; (b) interacting the first polyion with a second polyion having an opposite charge, the second polyion being fluorescently labeled; (c) providing reaction conditions so as to allow molecular weight discriminative interaction between the first polyion and the second polyion; and (d) employing a fluorescence polarization assay for determining a modulating effect of the agent on the induction of the molecular weight change of the first polyion.
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