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1.发明授权Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe 失效使用哺乳动物肝素酶作为探针筛选潜在的抗转移和抗炎药的方法公开(公告)号：US06190875B1
公开(公告)日：2001-02-20
申请号：US09113168
申请日：1998-07-10
申请人： Hanna Ben-Artzi , Maty Ayal-Hershkovitz , Israel Vlodavsky , Iris Pecker , Yoav Peleg , Daphna Miron
发明人： Hanna Ben-Artzi , Maty Ayal-Hershkovitz , Israel Vlodavsky , Iris Pecker , Yoav Peleg , Daphna Miron
IPC分类号： C12Q134
CPC分类号： C12Y302/01166 , A61K38/00 , A61L27/34 , C12N9/2402 , C12Q1/34 , C12Q1/527 , G01N2333/924 , G01N2333/988 , G01N2400/40 , G01N2500/20
摘要： Qualitative and quantitative methods of testing an agent for its potential at inhibiting glycosidase catalytic activity, the methods including the steps of interacting a glycosidase enzyme with a glycosidase substrate in a presence of the agent and qualitatively or quantitatively evaluating an effect of the agent on the catalytic activity of the glycosidase enzyme toward the glycosidase substrate. Preferably the glycosidase enzyme is a heparanase enzyme and the glycosidase substrate is, respectively, a heparanase substrate.
摘要翻译： 测定其抑制糖苷酶催化活性潜力的试剂的定性和定量方法，所述方法包括在试剂存在下将糖苷酶与糖苷酶底物相互作用的步骤，并定性或定量地评估试剂对催化剂的作用 糖苷酶对糖苷酶底物的活性。 优选地，糖苷酶是乙酰肝素酶，糖苷酶底物分别是乙酰肝素酶底物。
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2.发明授权Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same 有权用于表达重组肝素酶的转基因细胞和方法及其纯化方法公开(公告)号：US06348344B1
公开(公告)日：2002-02-19
申请号：US09260038
申请日：1999-03-02
申请人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madelene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Schlomi
发明人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madelene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Schlomi
IPC分类号： C12N942
CPC分类号： C12Y302/01166 , A61K38/00 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.
摘要翻译： 细菌，酵母和动物细胞和细胞系中过表达重组肝素酶的方法，从其中纯化重组肝素酶的方法和通过蛋白水解产生高活性乙酰肝素酶的前体的修饰的乙酰肝素酶。
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公开(公告)号：US06475763B1
公开(公告)日：2002-11-05
申请号：US09487716
申请日：2000-01-19
申请人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madlene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Shlomi
发明人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madlene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Shlomi
IPC分类号： C12Q100
CPC分类号： C12Y302/01166 , A61K38/00 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.
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公开(公告)号：US06946131B2
公开(公告)日：2005-09-20
申请号：US10368044
申请日：2003-02-19
申请人： Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz , Israel Vlodavsky , Yael Friedmann
发明人： Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz , Israel Vlodavsky , Yael Friedmann
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07K16/40 , C12N5/10 , C12N9/24 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/15 , G01N33/573 , G01N33/577
CPC分类号： C07K16/40 , A61K38/00 , A61K2039/505 , C12N9/2402 , C12Y302/01166 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： A method of treating a condition associated with heparanase expression by administering a heparanase activity neutralizing monoclonal anti-heparanase antibody, the monoclonal anti-heparanase antibody being for neutralizing heparanase catalytic activity.
摘要翻译： 通过施用乙酰肝素酶活性中和单克隆抗肝素酶抗体来治疗与肝素酶表达相关的病症的方法，所述单克隆抗肝素酶抗体用于中和肝素酶催化活性。
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公开(公告)号：US06562950B2
公开(公告)日：2003-05-13
申请号：US09186200
申请日：1998-11-04
申请人： Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz , Israel Vlodavsky , Yael Friedmann
发明人： Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz , Israel Vlodavsky , Yael Friedmann
IPC分类号： C07K1640
CPC分类号： C07K16/40 , A61K38/00 , A61K2039/505 , C12N9/2402 , C12Y302/01166 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： A monoclonal antibody elicited by a heparanase protein or an immunogenical portion thereof, the monoclonal antibody specifically inhibits heparanase activity.
摘要翻译： 由肝素酶蛋白或其免疫原性部分引发的单克隆抗体，单克隆抗体特异性抑制乙酰肝素酶活性。
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6.发明申请Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies 审中-公开肝素酶活性中和抗肝素酶单克隆抗体和其他抗肝素酶抗体公开(公告)号：US20060269552A1
公开(公告)日：2006-11-30
申请号：US10559925
申请日：2004-06-03
申请人： Oron Yacoby-Zeevi , Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz
发明人： Oron Yacoby-Zeevi , Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/73 , C07K2317/76 , C12Q1/34 , G01N33/6893
摘要： Specific anti-heparanase antibodies which bind specifically to heparanase having sequence homology to human heparanase, which can be used to treat and diagnose conditions associated with heparanase catalytic activity, for purification of heparanase, and for drug development in heparanase associated conditions are disclosed.
摘要翻译： 公开了特异性抗乙酰肝素酶抗体，其特异性结合具有与人类乙酰肝素酶具有序列同源性的乙酰肝素酶，其可用于治疗和诊断与肝素酶催化活性相关的病症，用于纯化乙酰肝素酶和用于乙酰肝素酶相关病症中的药物开发。
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7.发明申请METHODS FOR COVALENTLY ATTACHING A POLYMER TO A METHIONINE RESIDUE IN PROTEINS AND PEPTIDES 审中-公开将聚合物共同连接到蛋白质和蛋白质中的甲苯胺残留的方法公开(公告)号：US20110150820A1
公开(公告)日：2011-06-23
申请号：US13060439
申请日：2009-08-27
CPC分类号： A61K49/0002 , A61K47/60
摘要： Conjugates of polypeptides and a polymeric moiety such as PEG covalently attached to the sulfur atom of a methionine side chain are disclosed. Processes of preparing such conjugates, including intermediates and reagents utilized therefore are also disclosed. Further disclosed are therapeutic uses of these conjugates.
摘要翻译： 公开了多肽的共轭物和聚合部分，例如共价连接到甲硫氨酸侧链的硫原子上的PEG。 因此也公开了制备这种缀合物的方法，包括所用的中间体和试剂。 进一步公开的是这些缀合物的治疗用途。
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公开(公告)号：US20070185176A1
公开(公告)日：2007-08-09
申请号：US10588554
申请日：2005-02-06
申请人： Joel Van Gelder , Yochai Basel , Boris Kraiz , Orly Mouallem , Daphna Miron , Nina Gur-Arie , Joseph Klein
发明人： Joel Van Gelder , Yochai Basel , Boris Kraiz , Orly Mouallem , Daphna Miron , Nina Gur-Arie , Joseph Klein
IPC分类号： A61K31/425
CPC分类号： A61K31/415 , A61K31/136 , A61K31/16 , A61K31/185 , A61K31/21
摘要： The invention provides heparanase inhibitors suitable for treatment of diseases and disorders caused by or associated with heparanase catalytic activity such as cancer, inflammatory disorders and autoimmune diseases.
摘要翻译： 本发明提供了适用于治疗由肝素酶催化活性引起的或与肝素酶催化活性相关的疾病和病症的肝素酶抑制剂，例如癌症，炎症性疾病和自身免疫性疾病。
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9.发明申请Methods and pharmaceutical compositions for modulating heparanase activation and uses thereof 审中-公开用于调节乙酰肝素酶活化的方法和药物组合物及其用途公开(公告)号：US20050042213A1
公开(公告)日：2005-02-24
申请号：US10916598
申请日：2004-08-12
申请人： Joel Gelder , Daphna Miron
发明人： Joel Gelder , Daphna Miron
IPC分类号： A61K20060101 , A61K31/075 , A61K31/09 , A61K31/27 , A61K38/02 , A61K38/17 , A61K38/48 , C12N9/42 , C12N9/48 , C12N9/50 , C12Q1/37
CPC分类号： C12Q1/37 , A61K31/075 , A61K38/57
摘要： Methods of identifying proteases participating in heparanase activation, methods and pharmaceutical compositions useful in modulating heparanase activation and methods of modulating biological processes depending, at least in part, on heparanase activity are disclosed.
摘要翻译： 公开了至少部分取决于乙酰肝素酶活性的鉴定参与肝素酶活化的蛋白酶的方法，可用于调节乙酰肝素酶活化的方法和药物组合物以及调节生物学过程的方法。
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