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公开(公告)号：US10949973B2
公开(公告)日：2021-03-16
申请号：US16349374
申请日：2017-11-22
Applicant: Wake Forest University Health Sciences
Inventor： Jeongchul Kim , Youngkyoo Jung , Christopher T. Whitlow
Abstract: Post-image acquisition methods, circuits and systems for evaluating medical images of a subject register a region of interest in a first medical image taken at a first point in time to the region of interest in a second image taken before or after the first medical image with voxels from the first and second medical images having a voxel-wise correspondence. The methods, circuits and systems can use line and/or shape changes of defined 3-D finite elements to electronically determine directional, shear and volumetric changes of the voxels in the region of interest between the first and second medical images.
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2.发明授权Vascular territory segmentation using mutual clustering information from image space and label space 有权使用图像空间和标签空间中的相互聚类信息进行血管领域分割公开(公告)号：US09196037B2
公开(公告)日：2015-11-24
申请号：US14197567
申请日：2014-03-05
Applicant: Wake Forest University Health Sciences
Inventor： Youngkyoo Jung
CPC classification number: G06T7/0012 , A61B5/0042 , A61B5/0263 , A61B5/743 , A61B5/7445 , G06T7/155 , G06T7/90 , G06T11/008 , G06T2207/10081 , G06T2207/10088 , G06T2207/30016 , G06T2207/30101
Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional weighted CBF territory map of color-coded source artery locations using an automated vascular segmentation process to identify source locations using mutual connectivity in both image and label space.
Abstract translation: 方法，系统，计算机程序，电路和工作站被配置为使用自动血管分割过程来生成颜色编码的源动脉位置的至少一个二维加权CBF区域图，以使用图像和标签空间中的相互连接来识别源位置 。
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3.发明授权公开(公告)号：US10572999B2
公开(公告)日：2020-02-25
申请号：US15843708
申请日：2017-12-15
Applicant: Wake Forest University Health Sciences
Inventor： Youngkyoo Jung
Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional weighted CBF territory map of color-coded source artery locations using an automated vascular segmentation process to identify source locations using mutual connectivity in both image and label space.
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公开(公告)号：US20160324989A1
公开(公告)日：2016-11-10
申请号：US15110211
申请日：2015-01-13
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： King C. Li , Akiva Mintz , Xiaobing Xiong , Youngkyoo Jung , Yao Sun
IPC: A61K48/00 , A61K45/06 , A61K38/19 , A61K38/18 , C07K14/525 , A61M37/00 , C07K14/49 , A61K35/30 , C07K14/52 , A61K9/00 , A61K41/00 , C12N15/86 , A61K35/28 , C07K14/495
CPC classification number: A61K48/0083 , A61K9/0019 , A61K35/28 , A61K35/30 , A61K35/545 , A61K38/1841 , A61K38/1866 , A61K38/19 , A61K38/191 , A61K41/0047 , A61K45/06 , A61K48/005 , A61K48/0058 , A61K48/0066 , A61M37/0092 , A61P35/00 , C07K14/49 , C07K14/495 , C07K14/52 , C07K14/525 , C12N15/86 , C12N2830/002
Abstract: A method of increasing blood-brain barrier permeability of selected brain tissue in a subject in need thereof is carried out by: (a) parenterally administering to the subject stem cells that migrate to the brain tissue, the stem cells containing a recombinant nucleic acid, the recombinant nucleic acid comprising a nucleic acid encoding a barrier-opening protein or peptide operably associated with a heat-inducible promoter; and then (b) selectively heating the selected brain tissue sufficient to induce the expression of the barrier-opening protein or peptide in an amount effective to increase the permeability of the blood-brain barrier in the selected brain tissue. Nucleic acids, vectors, stem cells and compositions useful for carrying out such methods are also described.
Abstract translation: 通过以下方法进行选择性脑组织中选择的脑组织的血脑屏障通透性的方法：（a）胃肠外给予迁移至脑组织的干细胞，含有重组核酸的干细胞， 所述重组核酸包含编码与热诱导型启动子可操作地相关联的阻断开启蛋白或肽的核酸; 然后（b）选择性地加热所选择的脑组织足以诱导阻断开启蛋白或肽的表达，其量可以有效增加所选择的脑组织中血脑屏障的通透性。 还描述了用于实施这些方法的核酸，载体，干细胞和组合物。
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5.发明申请VESSEL ENCODED ARTERIAL SPIN LABELING USING FOURIER ENCODING SUITABLE FOR VASCULAR TERRITORY MAPPING 有权使用适用于瓦斯地图绘制的FOURIER编码的VESSEL编码的旋转标签公开(公告)号：US20130231554A1
公开(公告)日：2013-09-05
申请号：US13780323
申请日：2013-02-28
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Youngkyoo Jung
CPC classification number: A61B5/055 , A61B5/0263 , A61B5/7257 , A61B5/7425 , A61B2576/026 , G01R33/5608 , G01R33/56366 , G06T7/0012 , G06T2207/10088 , G06T2207/30016 , G06T2207/30104
Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional color blood flow map that combines X and Y encoded primary and secondary peak data of 1-dimensional Inverse Fourier Transform images to visually indicate (i) anterior/posterior and right/left directional components of respective feeding arteries using defined colors and (ii) brightness to indicate an amount of blood flow associated with each voxel, with increased brightness associated with increased blood flow.
Abstract translation: 方法，系统，计算机程序，电路和工作站被配置为生成至少一个二维彩色血流图，其组合了X维和Y编码的一维傅里叶逆变换图像的主峰数据和次峰值数据，以在视觉上指示（i） （ii）明亮度以指示与每个体素相关联的血流量，具有与增加的血液流量相关联的增加的亮度。
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Patent Agency Ranking
6.发明授权公开(公告)号：US09865051B2
公开(公告)日：2018-01-09
申请号：US14775271
申请日：2014-03-05
Applicant: Wake Forest University Health Sciences
Inventor： Youngkyoo Jung
CPC classification number: G06T7/0012 , A61B5/0042 , A61B5/0263 , A61B5/743 , A61B5/7445 , G06T7/155 , G06T7/90 , G06T11/008 , G06T2207/10081 , G06T2207/10088 , G06T2207/30016 , G06T2207/30101
Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional weighted CBF territory map of color-coded source artery locations using an automated vascular segmentation process to identify source locations using mutual connectivity in both image and label space.
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7.发明申请公开(公告)号：US20180225821A1
公开(公告)日：2018-08-09
申请号：US15843708
申请日：2017-12-15
Applicant: Wake Forest University Health Sciences
Inventor： Youngkyoo Jung
Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional weighted CBF territory map of color-coded source artery locations using an automated vascular segmentation process to identify source locations using mutual connectivity in both image and label space.
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8.发明授权Vessel encoded arterial spin labeling using fourier encoding suitable for vascular territory mapping 有权血管编码动脉自旋标记使用适用于血管区域映射的傅里叶编码公开(公告)号：US09468394B2
公开(公告)日：2016-10-18
申请号：US13780323
申请日：2013-02-28
Applicant: Wake Forest University Health Sciences
Inventor： Youngkyoo Jung
CPC classification number: A61B5/055 , A61B5/0263 , A61B5/7257 , A61B5/7425 , A61B2576/026 , G01R33/5608 , G01R33/56366 , G06T7/0012 , G06T2207/10088 , G06T2207/30016 , G06T2207/30104
Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional color blood flow map that combines X and Y encoded primary and secondary peak data of 1-dimensional Inverse Fourier Transform images to visually indicate (i) anterior/posterior and right/left directional components of respective feeding arteries using defined colors and (ii) brightness to indicate an amount of blood flow associated with each voxel, with increased brightness associated with increased blood flow.
Abstract translation: 方法，系统，计算机程序，电路和工作站被配置为生成至少一个二维彩色血流图，其组合了X维和Y编码的一维傅里叶逆变换图像的主峰数据和次峰值数据，以在视觉上指示（i） （ii）明亮度以指示与每个体素相关联的血流量，具有与增加的血液流量相关联的增加的亮度。
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9.发明申请VASCULAR TERRITORY SEGMENTATION USING MUTUAL CLUSTERING INFORMATION FROM IMAGE SPACE AND LABEL SPACE 有权使用图像空间和标签空间的相互聚集信息进行的波斯湾地区划分公开(公告)号：US20160019692A1
公开(公告)日：2016-01-21
申请号：US14775271
申请日：2014-03-05
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Youngkyoo Jung
CPC classification number: G06T7/0012 , A61B5/0042 , A61B5/0263 , A61B5/743 , A61B5/7445 , G06T7/155 , G06T7/90 , G06T11/008 , G06T2207/10081 , G06T2207/10088 , G06T2207/30016 , G06T2207/30101
Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional weighted CBF territory map of color-coded source artery locations using an automated vascular segmentation process to identify source locations using mutual connectivity in both image and label space.
Abstract translation: 方法，系统，计算机程序，电路和工作站被配置为使用自动血管分割过程来生成颜色编码的源动脉位置的至少一个二维加权CBF区域图，以使用图像和标签空间中的相互连接来识别源位置 。
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10.发明申请VASCULAR TERRITORY SEGMENTATION USING MUTUAL CLUSTERING INFORMATION FROM IMAGE SPACE AND LABEL SPACE 有权使用图像空间和标签空间的相互聚集信息进行的波斯湾地区划分公开(公告)号：US20140270442A1
公开(公告)日：2014-09-18
申请号：US14197567
申请日：2014-03-05
Applicant: Wake Forest University Health Sciences
Inventor： Youngkyoo Jung
IPC: G06T7/00
CPC classification number: G06T7/0012 , A61B5/0042 , A61B5/0263 , A61B5/743 , A61B5/7445 , G06T7/155 , G06T7/90 , G06T11/008 , G06T2207/10081 , G06T2207/10088 , G06T2207/30016 , G06T2207/30101
Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional weighted CBF territory map of color-coded source artery locations using an automated vascular segmentation process to identify source locations using mutual connectivity in both image and label space.
Abstract translation: 方法，系统，计算机程序，电路和工作站被配置为使用自动血管分割过程来生成颜色编码的源动脉位置的至少一个二维加权CBF区域图，以使用图像和标签空间中的相互连接来识别源位置 。
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