-
公开(公告)号：US08956849B2
公开(公告)日：2015-02-17
申请号：US12740608
申请日：2008-11-03
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
IPC分类号： C07H21/04 , C07H21/02 , C12N7/00 , C12N7/01 , C12N15/00 , C07K14/705 , C07K14/455 , A61K39/00
CPC分类号： A61K39/002 , A61K2039/523 , A61K2039/53 , C07K14/455 , C07K14/70575 , C07K2319/03 , Y02A50/412
摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
摘要翻译： 提供了包含TRAP多肽和包含TRAP多肽的肠炎沙门氏菌载体的疫苗。 疫苗还可以包括能够结合CD40的CD154多肽。 还提供了增强针对Apicomplexan寄生虫的免疫应答的方法和降低与Apicomplexan寄生虫感染相关的发病率的方法。
-
公开(公告)号：US20110027309A1
公开(公告)日：2011-02-03
申请号：US12441851
申请日：2007-09-18
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/00 , C12N15/63 , A61K39/02 , A61K39/145 , A61K39/112 , C12N1/21 , C12N15/64 , A61P37/04 , A61P31/16
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
摘要翻译： 本文提供了肠炎沙门氏菌13A菌株和包含这些菌株的组合物。 还提供了增强针对甲型流感的免疫应答的方法和降低与甲型流感感染相关的发病率的方法。 还公开了通过表达能够结合CD40的CD154多肽增强对疫苗载体的免疫应答的方法。 公开了开发细菌疫苗载体的方法。 还公开了在细菌中产生无疤痕位点突变的方法。
-
公开(公告)号：US20110111015A1
公开(公告)日：2011-05-12
申请号：US12740608
申请日：2008-11-03
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
IPC分类号： A61K9/127 , A61K39/00 , A61K39/12 , A61K39/02 , A61K39/112 , A61K39/07 , A61K39/108 , A61K39/002 , A61K39/012 , A61K39/015 , A61P37/04 , A61P33/02
CPC分类号： A61K39/002 , A61K2039/523 , A61K2039/53 , C07K14/455 , C07K14/70575 , C07K2319/03 , Y02A50/412
摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD4Q. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
摘要翻译： 提供了包含TRAP多肽和包含TRAP多肽的肠炎沙门氏菌载体的疫苗。 疫苗还可以包括能够结合CD4Q的CD154多肽。 还提供了增强针对Apicomplexan寄生虫的免疫应答的方法和降低与Apicomplexan寄生虫感染相关的发病率的方法。
-
公开(公告)号：US08604178B2
公开(公告)日：2013-12-10
申请号：US12441851
申请日：2007-09-18
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： C07H21/02 , A61K49/00 , A61K39/112
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
摘要翻译： 本文提供了肠炎沙门氏菌13A菌株和包含这些菌株的组合物。 还提供了增强针对甲型流感的免疫应答的方法和降低与甲型流感感染相关的发病率的方法。 还公开了通过表达能够结合CD40的CD154多肽增强对疫苗载体的免疫应答的方法。 公开了开发细菌疫苗载体的方法。 还公开了在细菌中产生无疤痕位点突变的方法。
-
5.发明申请COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO FLAGELLATED BACTERIUM 有权增强对细菌细菌的免疫反应的组合物和方法公开(公告)号：US20110159026A1
公开(公告)日：2011-06-30
申请号：US12740631
申请日：2008-10-30
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/112 , A61P37/04 , A61P31/04
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , Y02A50/482
摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
摘要翻译： 提供了包含fliC和CD154多肽的疫苗和包含fliC多肽的肠炎沙门氏杆菌疫苗载体。 还提供了增强针对鞭毛细菌的免疫应答的电弧法和减少与鞭毛细菌感染相关的发病率的方法。
-
6.发明授权Compositions and methods of enhancing immune responses to flagellated bacterium 有权增强对鞭毛细菌的免疫应答的组合物和方法公开(公告)号：US09125854B2
公开(公告)日：2015-09-08
申请号：US12740631
申请日：2008-10-30
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/02 , A61K39/112 , A61K39/00
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , Y02A50/482
摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
摘要翻译： 提供了包含fliC和CD154多肽的疫苗和包含fliC多肽的肠炎沙门氏杆菌疫苗载体。 还提供了增强针对鞭毛细菌的免疫应答的电弧法和减少与鞭毛细菌感染相关的发病率的方法。
-
公开(公告)号：US08956618B2
公开(公告)日：2015-02-17
申请号：US13574504
申请日：2011-01-21
申请人： Luc Berghman , Walter Bottje , Billy Hargis , Sherryll Layton
发明人： Luc Berghman , Walter Bottje , Billy Hargis , Sherryll Layton
IPC分类号： A61K49/00 , A61K39/00 , A61K39/12 , A61K39/385 , A61K39/145 , A61K39/02 , A61K45/00 , C12Q1/68
CPC分类号： A61K39/145 , A61K39/12 , A61K48/00 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/6006 , C12N7/00 , C12N2760/16034
摘要： Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
摘要翻译： 本文提供疫苗载体，其包含存在于疫苗载体表面上的抗原性多肽和HMGB1多肽。 还提供了包含疫苗载体的组合物，并且包括药学上可接受的载体，适合用于口服或鼻给药的载体。 还提供了通过将本文公开的疫苗载体或组合物施用于受试者来增强免疫应答，特别是抗体免疫应答和适当地IgA应答的方法。
-
公开(公告)号：US20120282291A1
公开(公告)日：2012-11-08
申请号：US13574504
申请日：2011-01-21
申请人： Luc Berghman , Walter Bottje , Billy Hargis , Sherryll Layton
发明人： Luc Berghman , Walter Bottje , Billy Hargis , Sherryll Layton
IPC分类号： A61K39/145 , A61P31/16 , C12N1/21
CPC分类号： A61K39/145 , A61K39/12 , A61K48/00 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/6006 , C12N7/00 , C12N2760/16034
摘要： Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
摘要翻译： 本文提供疫苗载体，其包含存在于疫苗载体表面上的抗原性多肽和HMGB1多肽。 还提供了包含疫苗载体的组合物，并且包括药学上可接受的载体，适合用于口服或鼻给药的载体。 还提供了通过将本文公开的疫苗载体或组合物施用于受试者来增强免疫应答，特别是抗体免疫应答和适当地IgA应答的方法。
-
公开(公告)号：US08961990B2
公开(公告)日：2015-02-24
申请号：US13702827
申请日：2011-06-09
申请人： Billy Hargis , Neil R. Pumford , Young Min Kwon , Sherryll Layton
发明人： Billy Hargis , Neil R. Pumford , Young Min Kwon , Sherryll Layton
IPC分类号： C07K14/205 , A61K39/02 , A61K39/00
CPC分类号： A61K39/12 , A61K39/105 , A61K2039/523 , A61K2039/53 , A61K2039/55516 , C07K14/205
摘要： Vaccine vectors and methods for enhancing resistance to Campylobacter infection or for enhancing the immune response to Campylobacter are provided herein. The vaccine vectors include a first polynucleotide which encodes an antigenic polypeptide selected from SEQ ID NO 7-9 or a fragment thereof. The vector may also include an immunostimulatory polypeptide. The methods include administering the vaccine vectors to a subject.
摘要翻译： 本文提供疫苗载体和用于增强对弯曲杆菌感染的抗性或增强对弯曲杆菌的免疫应答的方法。 疫苗载体包括编码选自SEQ ID NO：7-9或其片段的抗原性多肽的第一多核苷酸。 载体还可以包括免疫刺激多肽。 所述方法包括向受试者施用疫苗载体。
-
公开(公告)号：US20130084304A1
公开(公告)日：2013-04-04
申请号：US13702827
申请日：2011-06-09
申请人： Billy Hargis , Neil R. Pumford , Young Min Kwon , Sherryll Layton
发明人： Billy Hargis , Neil R. Pumford , Young Min Kwon , Sherryll Layton
IPC分类号： C07K14/205
CPC分类号： A61K39/12 , A61K39/105 , A61K2039/523 , A61K2039/53 , A61K2039/55516 , C07K14/205
摘要： Vaccine vectors and methods for enhancing resistance to Campylobacter infection or for enhancing the immune response to Campylobacter are provided herein. The vaccine vectors include a first polynucleotide which encodes an antigenic polypeptide selected from SEQ ID NO 7-9 or a fragment thereof. The vector may also include an immunostimulatory polypeptide. The methods include administering the vaccine vectors to a subject.
摘要翻译： 本文提供疫苗载体和用于增强对弯曲杆菌感染的抗性或增强对弯曲杆菌的免疫应答的方法。 疫苗载体包括编码选自SEQ ID NO：7-9或其片段的抗原性多肽的第一多核苷酸。 载体还可以包括免疫刺激多肽。 所述方法包括向受试者施用疫苗载体。
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.027 秒)
