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1.发明授权Substituted imidazo-fused 5-membered ring heterocycles as angiotensin II antagonists 失效取代的咪唑稠合的5元环杂环作为血管紧张素II拮抗剂
公开(公告)号：US5389660A
公开(公告)日：1995-02-14
申请号：US957588
申请日：1992-10-07
申请人： William J. Greenlee , David B. R. Johnston , Malcolm MacCoss , Nathan B. Mantlo , Arthur A. Patchett , Prasun K. Chakravarty , Thomas F. Walsh
发明人： William J. Greenlee , David B. R. Johnston , Malcolm MacCoss , Nathan B. Mantlo , Arthur A. Patchett , Prasun K. Chakravarty , Thomas F. Walsh
IPC分类号： A61K31/415 , A61K31/42 , A61K31/425 , A61P9/08 , A61P9/10 , A61P9/12 , A61P27/02 , A61P43/00 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D521/00 , C07F9/6561 , A61K31/41 , C07D487/02
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04
摘要： There are disclosed new substituted imidazo-fused 5-membered ring heterocyclic compounds and derivatives thereof which are useful as angiotensin II antagonists. These compounds have the general formula: ##STR1##
摘要翻译： 公开了可用作血管紧张素II拮抗剂的新的取代的咪唑并稠合的5元环杂环化合物及其衍生物。 这些化合物具有通式：（I）
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2.发明授权Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin II antagonsists 失效取代的IMIDAZO-FUSED 5结构环杂交体及其作为ANGIOTENSIN II拮抗剂的使用
公开(公告)号：US5164407A
公开(公告)日：1992-11-17
申请号：US516502
申请日：1990-04-25
申请人： William J. Greenlee , David B. R. Johnston , Malcolm MacCoss , Nathan B. Mantlo , Arthur A. Patchett , Prasun K. Chakravarty , Thomas F. Walsh
发明人： William J. Greenlee , David B. R. Johnston , Malcolm MacCoss , Nathan B. Mantlo , Arthur A. Patchett , Prasun K. Chakravarty , Thomas F. Walsh
IPC分类号： A61K31/415 , A61K31/42 , A61K31/425 , A61P9/08 , A61P9/10 , A61P9/12 , A61P27/02 , A61P43/00 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D521/00 , C07F9/6561
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04
摘要： There are disclosed new substituted imidazo-fused 5-membered ring heterocyclic compounds and derivatives thereof which are useful as angiotensin II antagonists. These compounds have the general formula: ##STR1##
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公开(公告)号：US5157040A
公开(公告)日：1992-10-20
申请号：US681216
申请日：1991-04-05
IPC分类号： A61K31/47 , A61P9/00 , A61P9/12 , A61P25/00 , A61P25/28 , A61P27/02 , A61P43/00 , C07D215/12 , C07D215/38 , C07D215/50 , C07D401/10 , C07D403/10 , C07D413/10
CPC分类号： C07D403/10 , C07D215/50
摘要： Substituted quinolines of the formula (I), are angiotensin II antagonists, ##STR1## and useful in the treatment of hypertension, ocular hypertension and certain CNS disorders.
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4.发明授权Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents 失效嘌呤及其等价物的哌嗪衍生物作为降血糖剂
公开(公告)号：US5057517A
公开(公告)日：1991-10-15
申请号：US393200
申请日：1989-08-14
IPC分类号： C07D471/04 , C07D473/16 , C07D473/24 , C07D473/32 , C07D473/34 , C07D473/40 , C07F7/08 , C07H19/16
CPC分类号： C07D471/04 , C07D473/16 , C07D473/24 , C07D473/32 , C07D473/34 , C07D473/40 , C07F7/0812 , C07H19/16
摘要： There are disclosed certain 6-piperazinopurines and heteroaromatic derivatives thereof which have oral hypoglycemic acitivity and with such ability to lower blood sugar are useful in the treatment of type II diabetes and/or obesity with associated insulin resistance. Processes for the preparation of such compounds and compositions containing such compounds as the active ingredient thereof are also disclosed.
摘要翻译： 公开了具有口服降血糖活性的某些6-哌嗪嘌呤和其杂芳族衍生物，并且具有降低血糖的能力可用于治疗具有相关胰岛素抵抗的II型糖尿病和/或肥胖症。 还公开了制备这些化合物和含有这些化合物作为其活性成分的组合物的方法。
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公开(公告)号：US20110306593A1
公开(公告)日：2011-12-15
申请号：US13128316
申请日：2009-11-11
申请人： Zhaoning Zhu , William J. Greenlee , Hongmei Li , Monica L. Vicarel , Jun Qin , Pawan Kumar Dhondi , Xianhai Huang , Anandan Palani , Xiaoxiang Liu , Zhong-Yue Sun , Hubert B. Josien , Ruo Xu , David James Cole , Duane A. Burnett , Chad E. Bennett , Troy McCracken , Malcolm MacCoss
发明人： Zhaoning Zhu , William J. Greenlee , Hongmei Li , Monica L. Vicarel , Jun Qin , Pawan Kumar Dhondi , Xianhai Huang , Anandan Palani , Xiaoxiang Liu , Zhong-Yue Sun , Hubert B. Josien , Ruo Xu , David James Cole , Duane A. Burnett , Chad E. Bennett , Troy McCracken , Malcolm MacCoss
IPC分类号： A61K31/553 , C07D498/10 , C07D498/04 , A61P25/28 , C07D413/14 , C07D498/14 , A61K31/5395 , C07D498/20 , C07D413/10
CPC分类号： C07D498/04 , C07D409/14 , C07D413/10 , C07D498/14 , C07D498/20
摘要： In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more disease associated with the central nervous system using such compounds or pharmaceutical compostions.
摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的下式杂环化合物：作为γ-分泌酶的调节剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种这样的化合物的药物制剂的方法 化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与中枢神经系统相关的一种或多种疾病的方法。
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6.发明授权Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists 失效作为血管紧张素II拮抗剂的取代的三唑啉酮，三唑啉硫酮和三唑啉亚胺
公开(公告)号：US5411980A
公开(公告)日：1995-05-02
申请号：US994228
申请日：1992-12-21
申请人： Wallace T. Ashton , Linda L. Chang , Malcolm MacCoss , Prasun K. Chakravarty , William J. Greenlee , Arthur A. Patchett , Kelly Flanagan
发明人： Wallace T. Ashton , Linda L. Chang , Malcolm MacCoss , Prasun K. Chakravarty , William J. Greenlee , Arthur A. Patchett , Kelly Flanagan
IPC分类号： C07D249/12 , C07D249/14 , C07D401/14 , C07D403/10 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/41
CPC分类号： C07D401/14 , C07D249/12 , C07D249/14 , C07D403/10 , C07D405/12 , C07D409/12 , C07D413/10
摘要： There are disclosed new substituted triazolinone, triazolinethione, and triazolinimine compounds which are useful as angiotensin II antagonists. These compounds have the general formula: ##STR1## wherein G is R.sup.1 or ##STR2##
摘要翻译： 公开了可用作血管紧张素II拮抗剂的新的取代的三唑啉酮，三唑啉硫酮和三唑啉亚胺化合物。 这些化合物具有以下通式：其中G为R 1或
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公开(公告)号：US5344830A
公开(公告)日：1994-09-06
申请号：US988514
申请日：1992-12-10
申请人： Sander G. Mills , Richard J. Budhu , Conrad P. Dorn , William J. Greenlee , Malcolm MacCoss , Mu T. Wu
发明人： Sander G. Mills , Richard J. Budhu , Conrad P. Dorn , William J. Greenlee , Malcolm MacCoss , Mu T. Wu
IPC分类号： C07D241/04 , A61K31/495 , C07D401/12 , C07D413/12
CPC分类号： C07D241/04
摘要： Diacylpiperazines of general structure ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
摘要翻译： 一般结构的二酰基哌嗪可以用于治疗炎性疾病，疼痛或偏头痛，哮喘和钙通道阻滞剂，可用于治疗心血管疾病如心绞痛，高血压或局部缺血。
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公开(公告)号：US5260285A
公开(公告)日：1993-11-09
申请号：US794534
申请日：1991-11-25
申请人： Eric E. Allen , William J. Greenlee , Prasun K. Chakravarty , Malcolm MacCoss , Arthur A. Patchett , Thomas F. Walsh
发明人： Eric E. Allen , William J. Greenlee , Prasun K. Chakravarty , Malcolm MacCoss , Arthur A. Patchett , Thomas F. Walsh
IPC分类号： C07D487/04 , A61K31/675 , A61K31/50 , A61K31/505
CPC分类号： C07D487/04
摘要： Novel substituted imidazopyridazines of formula (I) which are useful as angiotensin II antagonists, are disclosed. ##STR1##
摘要翻译： 公开了可用作血管紧张素II拮抗剂的式（I）的新型取代咪唑并哒嗪。 （一）
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公开(公告)号：US08809318B2
公开(公告)日：2014-08-19
申请号：US13128316
申请日：2009-11-11
申请人： Zhaoning Zhu , William J. Greenlee , Hongmei Li , Monica L. Vicarel , Jun Qin , Pawan Kumar Dhondi , Xianhai Huang , Anandan Palani , Xiaoxiang Liu , Zhong-Yue Sun , Hubert B. Josien , Ruo Xu , David James Cole , Duane A. Burnett , Chad E. Bennett , Troy McCracken , Malcolm MacCoss
发明人： Zhaoning Zhu , William J. Greenlee , Hongmei Li , Monica L. Vicarel , Jun Qin , Pawan Kumar Dhondi , Xianhai Huang , Anandan Palani , Xiaoxiang Liu , Zhong-Yue Sun , Hubert B. Josien , Ruo Xu , David James Cole , Duane A. Burnett , Chad E. Bennett , Troy McCracken , Malcolm MacCoss
IPC分类号： A61K31/553 , C07D498/04 , C07D498/14 , C07D498/20
CPC分类号： C07D498/04 , C07D409/14 , C07D413/10 , C07D498/14 , C07D498/20
摘要： In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more disease associated with the central nervous system using such compounds or pharmaceutical compostions.
摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的下式杂环化合物：作为γ-分泌酶的调节剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种这样的化合物的药物制剂的方法 化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与中枢神经系统相关的一种或多种疾病的方法。
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公开(公告)号：US5324729A
公开(公告)日：1994-06-28
申请号：US908143
申请日：1992-07-31
IPC分类号： C07D239/26 , C07D239/28 , C07D239/36 , C07D239/38 , C07D239/42 , C07D403/10 , C07D471/04 , C07F9/6512 , A61K31/505
CPC分类号： C07D239/26 , C07D239/28 , C07D239/36 , C07D239/38 , C07D239/42 , C07D403/10 , C07D471/04 , C07F9/65122
摘要： Substituted pyrimidines, pyrimidinones and pyridopyrimidines of formula (I) are as angiotensin II antagonists useful in the treatment of hypertension, ocular hypertension and certain CNS ailments: ##STR1## wherein K is --N(R.sup.8a)--C(.dbd.M) or --N.dbd.C(R.sup.8b) where M is O or NR.sup.22.
摘要翻译： 式（I）的取代的嘧啶，嘧啶酮和吡啶并嘧啶作为血管紧张素II拮抗剂，可用于治疗高血压，高眼压和某些CNS疾病：其中K为-N（R 8a）-C（= M） 或-N = C（R8b）其中M为O或NR22。
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