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公开(公告)号：US20100267049A1
公开(公告)日：2010-10-21
申请号：US12760518
申请日：2010-04-14
申请人： William J. RUTTER , George Harold Sierra , Hongjian Liu , Jimmy Z. Zhang , Zhihai Ye , Alexandre Izmailov , Brian David Warner
发明人： William J. RUTTER , George Harold Sierra , Hongjian Liu , Jimmy Z. Zhang , Zhihai Ye , Alexandre Izmailov , Brian David Warner
CPC分类号： G01N33/558 , G01N21/6428 , G01N21/658 , G01N21/76 , G01N21/77 , G01N21/78 , G01N21/8483 , G01N33/54366 , G01N33/582 , G01N35/00029 , G01N2021/6419 , G01N2021/6421 , G01N2021/7786 , G01N2035/00108
摘要： Devices, systems, and methods for detecting the presence of one or more analytes in a sample are described. In some variations, a test strip may be used to detect and/or analyze one or more analytes in a sample. In certain variations, a test strip configured to receive a sample for detection of an analyte therein may comprise a substrate and a coating on a portion of the substrate, the coating comprising a combination of a first analyte capture agent configured to bind to a first analyte and a second analyte capture agent configured to bind to a second analyte that is different from the first analyte.
摘要翻译： 描述用于检测样品中一种或多种分析物的存在的装置，系统和方法。 在一些变型中，测试条可用于检测和/或分析样品中的一种或多种分析物。 在某些变型中，被配置为接收用于检测其中的分析物的样品的测试条可以包括衬底和衬底的一部分上的涂层，所述涂层包括构造成结合到第一分析物的第一分析物捕获剂的组合 以及第二分析物捕获剂，被配置为结合不同于第一分析物的第二分析物。
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2.发明授权Methods and compositions for rapid light-activated isolation and detection of analytes 有权用于快速光激活分离和检测分析物的方法和组合物公开(公告)号：US07771947B2
公开(公告)日：2010-08-10
申请号：US12034236
申请日：2008-02-20
CPC分类号： C12Q1/6816 , C12Q2563/173 , C12Q2525/107
摘要： The present invention relates to novel methods for isolating a target molecule from a sample suspected of containing the target molecule. The methods of the present invention utilize solid substrates as a means for capturing, separating, and releasing target molecules, such as chemical or biological compounds. The present invention is specifically directed to novel approaches for capturing, separating and releasing such target molecules.
摘要翻译： 本发明涉及从怀疑含有靶分子的样品中分离靶分子的新方法。 本发明的方法利用固体底物作为捕获，分离和释放靶分子如化学或生物化合物的手段。 本发明特别涉及用于捕获，分离和释放这些靶分子的新方法。
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3.发明申请ASSAYS BASED ON DETECTION OF PHOTOBLEACHING REACTION PRODUCTS FROM DYE CATALYTIC COMPLEX 有权基于从染料复合物中检测光催化反应产物的测定公开(公告)号：US20100209909A1
公开(公告)日：2010-08-19
申请号：US12372439
申请日：2009-02-17
申请人： Miaomiao Wang , Rachel Anne Holmes-Davis , Rick Blidner , Zbigniew Rafinski , Beata Anna Jedrzejewska , Jerzy Paczkowski , Brian David Warner , Heather Koshinsky
发明人： Miaomiao Wang , Rachel Anne Holmes-Davis , Rick Blidner , Zbigniew Rafinski , Beata Anna Jedrzejewska , Jerzy Paczkowski , Brian David Warner , Heather Koshinsky
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q2563/107 , C12Q2525/107
摘要： The present invention relates to the methods for assaying an analyte comprising a nucleic acid analog binding substrate in a sample, comprising reacting a catalytic complex comprising a nucleic acid analog, a nucleic acid analog specific binding substrate and a light reactive dye with a light stimulus, and detecting the presence or absence or amount of a reaction product of the catalytic complex and light stimulus. The present invention also relates to a method of assaying a nucleic acid analyte in a sample using an analyte-specific reporter complex. The present invention also relates to a method of assaying an analyte in a sample using a reporter molecule.
摘要翻译： 本发明涉及用于测定样品中核酸类似物结合底物的分析物的方法，包括使包含核酸类似物，核酸类似特异性结合底物和轻活性染料的催化复合物与光刺激反应， 并检测催化复合物和光刺激的反应产物的存在或不存在或量。 本发明还涉及使用分析物特异性报道复合物测定样品中的核酸分析物的方法。 本发明还涉及使用报告分子测定样品中分析物的方法。
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4.发明申请METHODS AND COMPOSITIONS FOR RAPID LIGHT-ACTIVATED ISOLATION AND DETECTION OF ANALYTES 有权快速激活分离的方法和组合物和分析物的检测公开(公告)号：US20080220436A1
公开(公告)日：2008-09-11
申请号：US12034236
申请日：2008-02-20
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2563/173 , C12Q2525/107
摘要： The present invention relates to novel methods for isolating a target molecule from a sample suspected of containing the target molecule. The methods of the present invention utilize solid substrates as a means for capturing, separating, and releasing target molecules, such as chemical or biological compounds. The present invention is specifically directed to novel approaches for capturing, separating and releasing such target molecules.
摘要翻译： 本发明涉及从怀疑含有靶分子的样品中分离靶分子的新方法。 本发明的方法利用固体底物作为捕获，分离和释放靶分子如化学或生物化合物的手段。 本发明特别涉及用于捕获，分离和释放这些靶分子的新方法。
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公开(公告)号：US08021839B2
公开(公告)日：2011-09-20
申请号：US11710667
申请日：2007-02-23
申请人： Charles Robert Bupp, II , K. Yeon Choi , Rachel Anne Holmes-Davis , Alexander Izmailov , Heather Koshinsky , Christopher Jon Nulf , Mickey Urdea , Miaomiao Wang , Brian David Warner , Michael Zwick
发明人： Charles Robert Bupp, II , K. Yeon Choi , Rachel Anne Holmes-Davis , Alexander Izmailov , Heather Koshinsky , Christopher Jon Nulf , Mickey Urdea , Miaomiao Wang , Brian David Warner , Michael Zwick
CPC分类号： C12Q1/6876 , C12Q1/6813 , C12Q2600/156
摘要： Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a polynucleotide that may include nucleic acid analogs and that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/polynucleotide hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/polynucleotide hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.
摘要翻译： 提供了确定样品中靶多核苷酸的存在或量的方法。 含有靶多核苷酸，可包括核酸类似物并与靶多核苷酸的靶核酸序列互补的多核苷酸的样品和在存在和/或存在的情况下光学性质的变化率不同的染料 组合不存在靶多核苷酸/多核苷酸杂交体以产生反应混合物。 将反应混合物中染料的光学性质的变化率与含有已知量的多核苷酸/多核苷酸杂化物的类似反应混合物中的染料的光学性质变化率的变化率的参考值进行比较 确定光学性质的相对变化率。 反应混合物中染料的光学性质的相对变化率与样品中特定靶多核苷酸的存在或数量相关。
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6.发明授权Assays based on detection of photobleaching reaction products from dye catalytic complex 有权基于染料催化复合物的漂白反应产物的检测公开(公告)号：US07964355B2
公开(公告)日：2011-06-21
申请号：US12372439
申请日：2009-02-17
申请人： Maiomiao Wang , Rachel Anne Holmes-Davis , Rick Blidner , Zbigniew Rafinski , Beata Anna Jedrzejewska , Jerzy Paczkowski , Brian David Warner , Heather Koshinsky
发明人： Maiomiao Wang , Rachel Anne Holmes-Davis , Rick Blidner , Zbigniew Rafinski , Beata Anna Jedrzejewska , Jerzy Paczkowski , Brian David Warner , Heather Koshinsky
CPC分类号： C12Q1/6825 , C12Q2563/107 , C12Q2525/107
摘要： The present invention relates to the methods for assaying an analyte comprising a nucleic acid analog binding substrate in a sample, comprising reacting a catalytic complex comprising a nucleic acid analog, a nucleic acid analog specific binding substrate and a light reactive dye with a light stimulus, and detecting the presence or absence or amount of a reaction product of the catalytic complex and light stimulus. The present invention also relates to a method of assaying a nucleic acid analyte in a sample using an analyte-specific reporter complex. The present invention also relates to a method of assaying an analyte in a sample using a reporter molecule.
摘要翻译： 本发明涉及用于测定样品中核酸类似物结合底物的分析物的方法，包括使包含核酸类似物，核酸类似特异性结合底物和轻活性染料的催化复合物与光刺激反应， 并检测催化复合物和光刺激的反应产物的存在或不存在或量。 本发明还涉及使用分析物特异性报道复合物测定样品中的核酸分析物的方法。 本发明还涉及使用报告分子测定样品中分析物的方法。
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