公开(公告)号：US09366564B2

公开(公告)日：2016-06-14

申请号：US14115970

申请日：2012-05-23

申请人： Yasufumi Asao ,  Takao Nakajima

发明人： Yasufumi Asao ,  Takao Nakajima

IPC分类号： G01H9/00 ,  A61B5/00

CPC分类号： G01H9/00 ,  A61B5/0059

摘要： Use of an acoustic wave receiving apparatus which includes: a resonator including a first mirror on which measurement light is incident, a second mirror which is arranged to face the first mirror and on which acoustic waves from an object are incident, an acoustic wave reception layer interposed between the first mirror and the second mirror, and a compensation layer; and a detector for detecting a variation in an optical path length between the first mirror and the second mirror that occurs in response to deformation of the acoustic wave reception layer caused by incidence of the acoustic waves, wherein the variation in the optical path length due to a film thickness distribution of the acoustic wave reception layer is compensated by refraction in the compensation layer.

摘要翻译： 一种声波接收装置的应用，包括：谐振器，包括测量光入射的第一反射镜，布置成面对第一反射镜的第二反射镜，来自物体的声波入射;声波接收层 插入在第一反射镜和第二反射镜之间，以及补偿层; 以及检测器，用于检测响应于由声波入射引起的声波接收层的变形而发生的第一反射镜和第二反射镜之间的光路长度的变化，其中由于 通过在补偿层中的折射来补偿声波接收层的膜厚度分布。

公开(公告)号：US08144327B2

公开(公告)日：2012-03-27

申请号：US12548084

申请日：2009-08-26

申请人： Takao Nakajima ,  Kazuhiko Fukutani ,  Yasufumi Asao ,  Ryuichi Nanaumi

发明人： Takao Nakajima ,  Kazuhiko Fukutani ,  Yasufumi Asao ,  Ryuichi Nanaumi

IPC分类号： G01N21/00

CPC分类号： G01N21/1702 ,  A61B5/0059 ,  A61B5/0095 ,  A61B8/4281 ,  G01N2021/1706

摘要： A photoacoustic apparatus obtains information on a specimen by receiving photoacoustic waves which are generated from the specimen resulting from light irradiated to the specimen. The apparatus includes a light source for irradiating light to the specimen, an acoustic wave receiver for receiving the photoacoustic waves, and a light reflection member for causing the light, which is radiated out of the specimen by optical diffusion thereof after having entered an interior of the specimen from the light source, to reenter the interior of the specimen, wherein the light reflection member allows elastic waves to pass therethrough. As a result, a photoacoustic apparatus and a probe are provided which can confine scattered light from the specimen into the specimen, and which can reliably prevent photoacoustic waves from being generated from a receiving element region of the probe by the scattered light.

公开(公告)号：US07864307B2

公开(公告)日：2011-01-04

申请号：US12204445

申请日：2008-09-04

申请人： Kazuhiko Fukutani ,  Takao Nakajima ,  Yasufumi Asao ,  Toru Den

发明人： Kazuhiko Fukutani ,  Takao Nakajima ,  Yasufumi Asao ,  Toru Den

IPC分类号： G01N21/00

CPC分类号： A61B5/0073 ,  A61B5/0035 ,  A61B5/0095

摘要： A biological information imaging apparatus includes: a light source; an acoustic wave detector that detects an acoustic wave generated from a light absorption material in a living body that has absorbed a part of energy of light irradiated from the light source to the living body, and converts it into a first electric signal; a photodetector that detect optical intensity of a portion of the light irradiated from the light source to the living body and propagating in the living body, and converts it into a second electric signal; and a calculation unit that calculates optical property distribution information on the living body by making use of an analytical result of one of the first electric signal and the second electric signal for analysis of the other electric signal.

摘要翻译： 生物信息成像装置包括：光源; 声波检测器，其检测从吸收从光源照射到生物体的光的一部分能量的生物体中的光吸收材料产生的声波，并将其转换为第一电信号; 光检测器，其检测从光源照射到生物体并在生物体中传播的光的一部分的光强度，并将其转换为第二电信号; 以及计算单元，其通过利用第一电​​信号和第二电信号中的一个的分析结果来计算其他电信号的分析结果来计算生物体的光学性质分布信息。

公开(公告)号：US20100174197A1

公开(公告)日：2010-07-08

申请号：US12602715

申请日：2008-06-20

申请人： Takao Nakajima ,  Kazuhiko Fukutani ,  Yasufumi Asao

发明人： Takao Nakajima ,  Kazuhiko Fukutani ,  Yasufumi Asao

IPC分类号： A61B6/00

CPC分类号： A61B5/0095 ,  A61B1/018 ,  A61B1/0623 ,  A61B1/07 ,  A61B1/313 ,  A61B5/0084 ,  A61B17/3478

摘要： A living body information imaging apparatus includes a member that is adapted to be introduced into an interior of a living body and has a light irradiation portion for irradiating light with an angle of irradiation equal to or more than 2π steradian to the interior of the living body, and a signal detector that is arranged outside the living body and detects a signal output based on light irradiation in the interior of the living body by the member having the light irradiation portion.

摘要翻译： 生物体信息摄像装置包括适于被引入到生物体的内部并具有用于以等于或大于2的照射角照射光的光照射部的构件; 功能体，以及信号检测器，其布置在生物体外部，并且通过具有光照射部分的部件检测基于在生物体内部的光照射的信号输出。

公开(公告)号：US20100087733A1

公开(公告)日：2010-04-08

申请号：US12574086

申请日：2009-10-06

申请人： Takao Nakajima ,  Kazuhiko Fukutani ,  Yasufumi Asao

发明人： Takao Nakajima ,  Kazuhiko Fukutani ,  Yasufumi Asao

IPC分类号： A61B8/00 ,  A61B6/00

CPC分类号： A61B5/0073 ,  A61B5/0095 ,  A61B8/13 ,  G01N21/1702

摘要： A biological information processing apparatus has a light source 102 which emits a light 101 to a living body 100; an acoustic wave detector 106 that detects an acoustic wave 105 which a light absorber 104 in the living body generates when it absorbs the light, and that converts the acoustic wave to an electric signal; and a signal processing unit 108 that obtains information in the living body from the electric signal and a light quantity distribution in the living body determined based on a shape of the living body.

摘要翻译： 生物信息处理装置具有向生物体100照射光101的光源102; 声波检测器106，其检测当吸收光时生物体中的光吸收体104产生的声波105，并将声波转换成电信号; 以及信号处理单元108，其从电信号和基于生物体的形状确定的生物体中的光量分布获取生物体内的信息。

公开(公告)号：US20090198128A1

公开(公告)日：2009-08-06

申请号：US12365237

申请日：2009-02-04

申请人： KAZUHIKO FUKUTANI ,  Takao Nakajima ,  Yasufumi Asao

发明人： KAZUHIKO FUKUTANI ,  Takao Nakajima ,  Yasufumi Asao

IPC分类号： A61B8/00

CPC分类号： A61B5/0095 ,  A61B5/0091 ,  A61B5/4312 ,  A61B5/4887 ,  A61B5/489 ,  A61B8/0825 ,  A61B8/4416 ,  A61B8/5223 ,  G01N29/2418

摘要： There are provided a biological information imaging apparatus that can measure ultrasound generated from an optical absorber in a deep part of a subject living bodywith high sensitivity, and a method for analyzing biological information using the biological information imaging apparatus. The biological information imaging apparatus that detects ultrasound and images biological information, includes: a light source that irradiates the subject with light for generating ultrasound from an optical absorber existing in the subject; an ultrasound transmission unit that transmits focus ultrasound to a specific region where the optical absorber exists; and an ultrasound detection unit that detects an ultrasound synthesized signal due to interaction between ultrasound generated from the optical absorber that absorbs the light and the focus ultrasound transmitted to the specific region.

摘要翻译： 本发明提供一种生物信息成像装置，其能够高灵敏度地测量被检体活体的深部的光吸收体产生的超声波，以及使用生物信息成像装置分析生物体信息的方法。 检测超声波和图像生物信息的生物信息成像装置包括：从存在于被检体内的光吸收体照射被检体的光用于产生超声的光源; 超声波发送单元，其将聚焦超声波发送到存在光吸收体的特定区域; 以及超声波检测单元，其检测由吸收光的吸收体产生的超声波与发送到特定区域的聚焦超声波之间的相互作用引起的超声合成信号。

公开(公告)号：US20130267823A1

公开(公告)日：2013-10-10

申请号：US13993730

申请日：2011-12-28

申请人： Takao Nakajima ,  Yasufumi Asao

发明人： Takao Nakajima ,  Yasufumi Asao

IPC分类号： A61B5/00

CPC分类号： A61B5/0095 ,  A61B5/0091 ,  A61B5/708 ,  A61B5/72 ,  A61B5/742

摘要： A measuring apparatus has a holding unit for holding an object, and a probe including a receiving element for receiving through the holding unit an acoustic wave generated by the object irradiated with light. The light is applied to an object surface held by the holding unit. The probe is arranged such that a direction of a normal to the object surface held by the holding unit is nonparallel to a direction in which the receiving element exhibits its highest reception sensitivity.

摘要翻译： 测量装置具有用于保持物体的保持单元和包括接收元件的探针，用于通过保持单元接收由被照射的光产生的声波。 光被施加到由保持单元保持的物体表面。 探针被布置成使得由保持单元保持的物体表面的法线方向与接收元件呈现最高接收灵敏度的方向不平行。

公开(公告)号：US08300224B2

公开(公告)日：2012-10-30

申请号：US13367894

申请日：2012-02-07

申请人： Takao Nakajima ,  Kazuhiko Fukutani ,  Yasufumi Asao ,  Ryuichi Nanaumi

发明人： Takao Nakajima ,  Kazuhiko Fukutani ,  Yasufumi Asao ,  Ryuichi Nanaumi

IPC分类号： G01N21/00

CPC分类号： G01N21/1702 ,  A61B5/0059 ,  A61B5/0095 ,  A61B8/4281 ,  G01N2021/1706

摘要： A photoacoustic apparatus obtains information on a specimen by receiving photoacoustic waves which are generated from the specimen resulting from light irradiated to the specimen. The apparatus includes a light source for irradiating light to the specimen, an acoustic wave receiver for receiving the photoacoustic waves, and a light reflection member for causing the light, which is radiated out of the specimen by optical diffusion thereof after having entered an interior of the specimen from the light source, to reenter the interior of the specimen, wherein the light reflection member allows elastic waves to pass therethrough. As a result, a photoacoustic apparatus and a probe are provided which can confine scattered light from the specimen into the specimen, and which can reliably prevent photoacoustic waves from being generated from a receiving element region of the probe by the scattered light.

摘要翻译： 光声设备通过接收由照射到样本的光产生的样本产生的光声来获得关于样本的信息。 该装置包括用于向样本照射光的光源，用于接收光声波的声波接收器，以及光反射构件，其用于使得通过其进入其内部的光学扩散而从样本中辐射出的光 来自光源的样本，重新进入样本的内部，其中光反射构件允许弹性波通过。 结果，提供了一种光声装置和探针，其可以将来自样本的散射光限制在样本中，并且可以可靠地防止通过散射光从探测器的接收元件区域产生光声波。

公开(公告)号：US20140076055A1

公开(公告)日：2014-03-20

申请号：US14115970

申请日：2012-05-23

申请人： Yasufumi Asao ,  Takao Nakajima

发明人： Yasufumi Asao ,  Takao Nakajima

IPC分类号： G01H9/00

CPC分类号： G01H9/00 ,  A61B5/0059

摘要： Use of an acoustic wave receiving apparatus which includes: a resonator including a first mirror on which measurement light is incident, a second mirror which is arranged to face the first mirror and on which acoustic waves from an object are incident, an acoustic wave reception layer interposed between the first mirror and the second mirror, and a compensation layer; and a detector for detecting a variation in an optical path length between the first mirror and the second mirror that occurs in response to deformation of the acoustic wave reception layer caused by incidence of the acoustic waves, wherein the variation in the optical path length due to a film thickness distribution of the acoustic wave reception layer is compensated by refraction in the compensation layer.

摘要翻译： 一种声波接收装置的应用，包括：谐振器，包括测量光入射的第一反射镜，布置成面对第一反射镜的第二反射镜，来自物体的声波入射;声波接收层 插入在第一反射镜和第二反射镜之间，以及补偿层; 以及检测器，用于检测响应于由声波入射引起的声波接收层的变形而发生的第一反射镜和第二反射镜之间的光路长度的变化，其中由于 通过在补偿层中的折射来补偿声波接收层的膜厚分布。

公开(公告)号：US20120133941A1

公开(公告)日：2012-05-31

申请号：US13367894

申请日：2012-02-07

申请人： Takao Nakajima ,  Kazuhiko Fukutani ,  Yasufumi Asao ,  Ryuichi Nanaumi

发明人： Takao Nakajima ,  Kazuhiko Fukutani ,  Yasufumi Asao ,  Ryuichi Nanaumi

IPC分类号： G01N21/55

CPC分类号： G01N21/1702 ,  A61B5/0059 ,  A61B5/0095 ,  A61B8/4281 ,  G01N2021/1706

摘要： A photoacoustic apparatus obtains information on a specimen by receiving photoacoustic waves which are generated from the specimen resulting from light irradiated to the specimen. The apparatus includes a light source for irradiating light to the specimen, an acoustic wave receiver for receiving the photoacoustic waves, and a light reflection member for causing the light, which is radiated out of the specimen by optical diffusion thereof after having entered an interior of the specimen from the light source, to reenter the interior of the specimen, wherein the light reflection member allows elastic waves to pass therethrough. As a result, a photoacoustic apparatus and a probe are provided which can confine scattered light from the specimen into the specimen, and which can reliably prevent photoacoustic waves from being generated from a receiving element region of the probe by the scattered light.

摘要翻译： 光声设备通过接收由照射到样本的光产生的样本产生的光声来获得关于样本的信息。 该装置包括用于向样本照射光的光源，用于接收光声波的声波接收器，以及光反射构件，其用于使得通过其进入其内部的光学扩散而从样本中辐射出的光 来自光源的样本，重新进入样本的内部，其中光反射构件允许弹性波通过。 结果，提供了一种光声装置和探针，其可以将来自样本的散射光限制在样本中，并且可以可靠地防止通过散射光从探测器的接收元件区域产生光声波。