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    Mutilin-Derivative Substituted at Position 12
    3.
    发明申请
    Mutilin-Derivative Substituted at Position 12 审中-公开
    在第12位取代的Mutilin衍生物

    公开(公告)号：US20080221330A1

    公开(公告)日：2008-09-11

    申请号：US11794312

    申请日：2005-12-21

    申请人： Masanori Takadoi ,  Yasumichi Fukuda ,  Taro Sato ,  Osamu Nagae ,  Ryuta Kishi ,  Hideyuki Fukuda

    发明人： Masanori Takadoi ,  Yasumichi Fukuda ,  Taro Sato ,  Osamu Nagae ,  Ryuta Kishi ,  Hideyuki Fukuda

    IPC分类号： C07D453/00

    CPC分类号： C07C317/24 ,  C07C49/487 ,  C07C49/517 ,  C07C49/753 ,  C07C69/003 ,  C07C69/675 ,  C07C235/82 ,  C07C251/42 ,  C07C255/31 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2603/82 ,  C07D487/08

    摘要： A position 12-substituted mutilin derivative, a novel mutilin analogue, is provided that exhibits strong antimicrobial activity against abroad spectrum of Gram-positive or Gram-negative bacteria, including various drug-resistant bacteria, as well as intermediates for the production of such mutilin derivatives.Specifically, a mutilin derivative or an acid-addition salt thereof is provided that is represented by the following chemical formula (1): (wherein R1 is a hydrogen atom, a formyl group, a substituted or unsubstituted lower alkyl group, an aralkyl group whose aromatic ring may be optionally substituted, a heteroaralkyl group whose aromatic ring may be optionally substituted or a lower alkyloxycarbonyl group; and R2 is a hydrogen atom, a lower alkyl group or an aralkyl group whose aromatic ring may be optionally substituted) (R1 is neither an ethyl group nor a vinyl group).

    摘要翻译： 提供了一种位置12-取代的mutilin衍生物，一种新的mutilin类似物，其显示出对革兰氏阳性或革兰氏阴性细菌（包括各种耐药性细菌）的国外光谱的强抗微生物活性，以及​​用于生产这种mutilin的中间体 衍生品 具体而言，提供由以下化学式（1）表示的脯氨酸衍生物或其酸加成盐：（其中R 1是氢原子，甲酰基，取代或未取代的 芳基可以任选被取代的芳烷基，芳香环可以被任选取代的杂芳烷基或低级烷氧基羰基; R 2是氢原子，低级烷基 或其芳环可以任选被取代的芳烷基）（R 1 O 2既不是乙基也不是乙烯基）。

    Method of controlling operation of tandem rolling mill and method of manufacturing hot-rolled steel sheet using the same
    4.
    发明授权
    Method of controlling operation of tandem rolling mill and method of manufacturing hot-rolled steel sheet using the same 有权
    串列式轧机的控制方法及使用该方法制造热轧钢板的方法

    公开(公告)号：US08850860B2

    公开(公告)日：2014-10-07

    申请号：US13625283

    申请日：2012-09-24

    申请人： Daisuke Nikkuni ,  Suguhiro Fukushima ,  Yoshiro Washikita ,  Tetsuo Kajihara ,  Kenji Horii ,  Taro Sato

    发明人： Daisuke Nikkuni ,  Suguhiro Fukushima ,  Yoshiro Washikita ,  Tetsuo Kajihara ,  Kenji Horii ,  Taro Sato

    IPC分类号： B21B37/16 ,  B21B37/72 ,  B21B1/24

    CPC分类号： B21B37/72 ,  B21B1/24 ,  B21B1/26 ,  B21B37/64 ,  B21B2265/12 ,  B21B2273/14

    摘要： Provided is a method of controlling operation of a tandem rolling mill which enables large reduction rolling in the latter-stage stand of the tandem rolling mill necessary for manufacturing fine-grained steel, and so on. The method comprises: a step of determining a first exit-side sheet thickness in rolling a constant portion of a material to be rolled; and a step of determining a second exit-side sheet thickness in rolling a front end portion of the material, such that a pre-tightening load becomes a set value or less; the material is rolled into the second exit-side sheet thickness, until the front end portion is fed into the stands; the constant portion is rolled by the stand given a pre-tightening load into the first exit-side sheet thickness; and the second exit-side sheet thicknesses of the stands given the pre-tightening load are made larger than the first exit-side sheet thickness.

    摘要翻译： 提供一种控制串联式轧机的操作的方法，其能够在制造细晶钢所需的串列式轧机的后级机架中进行大的压下等。 该方法包括：确定第一出口侧片材厚度滚动待轧制材料的恒定部分的步骤; 以及确定在材料的前端部分滚动的第二出口侧片材厚度的步骤，使得预紧负载变为设定值或更小; 将材料卷入第二出口侧片材厚度，直到前端部分被供给到支架中; 所述恒定部分通过预紧力负载被所述支架轧制到所述第一出口侧板材厚度中; 并且使得具有预紧力负载的支架的第二出口侧片材厚度大于第一出口侧片材厚度。

    METHOD OF CONTROLLING OPERATION OF TANDEM ROLLING MILL AND METHOD OF MANUFACTURING HOT-ROLLED STEEL SHEET USING THE SAME
    5.
    发明申请
    METHOD OF CONTROLLING OPERATION OF TANDEM ROLLING MILL AND METHOD OF MANUFACTURING HOT-ROLLED STEEL SHEET USING THE SAME 有权
    控制轧制轧机的操作方法及使用其制造热轧钢板的方法

    公开(公告)号：US20130019646A1

    公开(公告)日：2013-01-24

    申请号：US13625283

    申请日：2012-09-24

    申请人： Daisuke NIKKUNI ,  Suguhiro Fukushima ,  Yoshiro Washikita ,  Tetsuo Kajihara ,  Kenji Horii ,  Taro Sato

    发明人： Daisuke NIKKUNI ,  Suguhiro Fukushima ,  Yoshiro Washikita ,  Tetsuo Kajihara ,  Kenji Horii ,  Taro Sato

    IPC分类号： B21B37/16

    CPC分类号： B21B37/72 ,  B21B1/24 ,  B21B1/26 ,  B21B37/64 ,  B21B2265/12 ,  B21B2273/14

    摘要： Provided is a method of controlling operation of a tandem rolling mill which enables large reduction rolling in the latter-stage stand of the tandem rolling mill necessary for manufacturing fine-grained steel, and so on. The method comprises: a step of determining a first exit-side sheet thickness in rolling a constant portion of a material to be rolled; and a step of determining a second exit-side sheet thickness in rolling a front end portion of the material, such that a pre-tightening load becomes a set value or less; the material is rolled into the second exit-side sheet thickness, until the front end portion is fed into the stands; the constant portion is rolled by the stand given a pre-tightening load into the first exit-side sheet thickness; and the second exit-side sheet thicknesses of the stands given the pre-tightening load are made larger than the first exit-side sheet thickness.

    摘要翻译： 提供一种控制串联式轧机的操作的方法，其能够在制造细晶钢所需的串列式轧机的后级机架中进行大的压下等。 该方法包括：确定第一出口侧片材厚度滚动待轧制材料的恒定部分的步骤; 以及确定在材料的前端部分滚动的第二出口侧片材厚度的步骤，使得预紧负载变为设定值或更小; 将材料卷入第二出口侧片材厚度，直到前端部分被供给到支架中; 所述恒定部分通过预紧力负载被所述支架轧制到所述第一出口侧板材厚度中; 并且使得具有预紧力负载的支架的第二出口侧片材厚度大于第一出口侧片材厚度。